Výsledky vyhledávání - "Pamela A. Althof"

High‐risk cytogenetics in multiple myeloma: Further scrutiny of deletions within theIGHgene region enhances risk stratification

Autor: Jennifer N. Sanmann, Scott C. Smith, Pamela A. Althof, Bhavana J. Dave

Publikováno v: Genes, Chromosomes and Cancer. 59:569-574

Multiple myeloma is a clonal malignancy of plasma cells in the bone marrow. Risk stratification is partly based on cytogenetic findings that include abnormalities of the IGH locus as determined by fluorescence in situ hybridization (FISH), such as re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70daaa9f48ffc56b49ab4eb2267245dc
https://doi.org/10.1002/gcc.22874

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Frequency, variations, and prognostic implications of chromosome 14q32 deletions in chronic lymphocytic leukemia

Autor: Bhavana J. Dave, Pamela A. Althof, Rachel A. Harris, Diane L. Pickering, Jadd M. Stevens, Jennifer N. Sanmann, Lynette M. Smith

Publikováno v: Leukemia research. 110

The clinical implications of deletions within chromosome 14q32 in CLL pathogenesis remain unclear. We examined the frequency of 14q32 deletions among CLL cases by karyotype and FISH, categorized the variation using genomic microarray, and assessed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bda52b5e23bb5dc2c15222cff4ab6fc
https://pubmed.ncbi.nlm.nih.gov/34293710

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MECOM rearrangement involving the MYC locus: Two additional patients with the rare translocation, t(3;8)(q26.2;q24), and molecular review

Autor: Jennifer N. Sanmann, Pamela A. Althof, Bhavana J. Dave, Scott C. Smith, Tareq Z.S. Qdaisat

Publikováno v: Leukemia research. 95

A relatively small subset of myeloid neoplasms involve rearrangements of cytoband 3q26.2. Such rearrangements are often in response to therapy and carry a poor prognosis. The ectopic expression of MECOM is the result of such translocations. To date,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25a680ae0a5df7a814fc21f9e478967
https://pubmed.ncbi.nlm.nih.gov/32535247

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Abstract P2-03-09: Autocrine motility factor signaling pathway promotes aggressive behavior and migration in breast cancer

Autor: Pamela A. Althof, AZ VanDyke, SP Thayer, D Maroni, JN Sanmann, Prosenjit Mondal, Cassie J Liu, JD Price, JM Stevens

Publikováno v: Cancer Research. 79:P2-03

Background: Autocrine motility factor (AMF) is secreted by cancer cells and acts in an autocrine or paracrine fashion to bind to its receptor, AMFR, at the cell surface of tumor cells. The AMF-AMFR pathway has been shown to promote proliferation, ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7e27e7cad65083092ad7a46ca105caf
https://doi.org/10.1158/1538-7445.sabcs18-p2-03-09

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Abstract P3-01-21: Circulating tumor cells of breast cancer origin identified by fluorescence in situ hybridization and may be an early predictor of therapy failure in early breast cancer

Autor: JM Stevens, AZ VanDyke, CE Grabow, JN Sanmann, JD Price, Pamela A. Althof, D Maroni, SP Thayer, Cassie J Liu

Publikováno v: Cancer Research. 79:P3-01

Background: Most modern methods of detecting circulating tumor cells (CTCs) involve identifying cells with epithelial markers. This approach presents challenges, as not all epithelial cells found in circulation originate from the tumor and not all CT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2ce5116bce4ada547cd73bffa8bb485
https://doi.org/10.1158/1538-7445.sabcs18-p3-01-21

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Genome wide copy number analysis of paediatric Burkitt lymphoma using formalin-fixed tissues reveals a subset with gain of chromosome 13q and corresponding miRNA over expression

Autor: Rodney R. Miles, Mona S. Jahromi, Joshua D. Schiffman, Jonathan M. Downie, Sherrie L. Perkins, Pamela A. Althof, Phillip Barnette, Jennifer N. Sanmann, Patrick D. Lorimer, Vladimir Rodic, Warren G. Sanger, Michael G. Bayerl

Publikováno v: British Journal of Haematology. 155:477-486

The majority of paediatric Burkitt lymphoma (pBL) patients that relapse will die of disease, but markers for this high-risk subset are unknown. MYC translocations characterize pBL, but additional genetic changes may relate to prognosis and serve as p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ab6f8e2de3dc763072366395109d447
https://doi.org/10.1111/j.1365-2141.2011.08883.x

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Utilizing Y Chromosome FISH to Determine the Origin of Post-Transplant Lymphoproliferative Disease in Solid Organ Transplant Recipients

Autor: Alan Norman Langnas, Wendy J. Grant, Martin Bast, Valerie Shostrom, James B. Ford, Pamela A. Althof, Kelly Erickson, Sanmann N Jennifer, Timothy C. Greiner, Peter F. Coccia

Publikováno v: Blood. 132:5297-5297

Background: Post-Transplant Lymphoproliferative Disease (PTLD) is a heterogeneous disease that arises as a complication after solid organ transplants (SOT) and unusually after bone marrow transplants (BMT). PTLD is generally of recipient origin in SO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::448096affb390ba775e62699bb8f340a
https://doi.org/10.1182/blood-2018-99-119488

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Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Autor: Robert Tanner, Hagelstrom, James, Ford, Gwendolyn M, Reiser, Marilu, Nelson, Diane L, Pickering, Pamela A, Althof, Warren G, Sanger, Peter F, Coccia

Publikováno v: Pediatric bloodcancer. 63(3)

Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2d924c8d35ddd26ca9fdcc4862f0ac3
https://pubmed.ncbi.nlm.nih.gov/26468640

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Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study

Autor: Shi Wei, Claudia Velosa, Margaret Brandwein-Gensler, Walter C. Bell, William R. Carroll, Qiuying Shi, Andra O Kovalovsky, Jennifer N. Sanmann, Larissa Sweeny, Randall P. Owen, Qian Dai, Martin J. Bullock, Pamela A. Althof, Todd M. Stevens, Gene P. Siegal

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 28(8)

Mammary analog secretory carcinoma (MASC) is a recently recognized low-grade salivary carcinoma characterized by a specific ETV6 rearrangement. We describe 14 new MASCs and examine their immunophenotypic and genetic profiles in the context of look-al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7897c4a0a6572dec7e5b98b53a5d8504
https://pubmed.ncbi.nlm.nih.gov/28144036

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