Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Pamela, Santiago"'
Autor:
Wagner Antonio dos Santos Lima, Jane Matos, Odeval Veras de Carvalho, Pamela Santiago de Brito, Lisanil da Conceição Patrocinio Pereira
Publikováno v:
Cadernos Cajuína, Vol 9, Iss 2 (2024)
Estudo, realizado como parte do curso de mestrado em Geografia na Universidade do Estado de Mato Grosso, com objetivo de analisar a fragilidade ambiental do córrego Lava-pés em Cáceres, Mato Grosso. A aplicação do Protocolo de Avaliação Rápid
Externí odkaz:
https://doaj.org/article/e472e3b4e11a43e68ddeec8ad51c26c8
Autor:
Pamela Zhang, Guang Huan Tu, Jie Wei, Pamela Santiago, Lance R. Larrabee, Sindy Liao-Chan, Tina Mistry, Matthew Ling-Hon Chu, Tao Sai, Kevin Lindquist, Hua Long, Javier Chaparro-Riggers, Shahram Salek-Ardakani, Yik Andy Yeung
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3117-3123.e5 (2019)
Summary: Agonistic antibodies targeting the tumor necrosis factor (TNF) superfamily of co-stimulatory receptors (TNFRSF) are progressing through various stages of clinical development for cancer treatment, but the desired and defining features of the
Externí odkaz:
https://doaj.org/article/44cb539f22be4485ababb5654bc38b0f
Autor:
Natalija, Van Braeckel-Budimir, Joseph Samuel, Dolina, Jie, Wei, Xiao, Wang, Shih-Hsun, Chen, Pamela, Santiago, Guanghuan, Tu, Luca, Micci, Amir A, Al-Khami, Sophia, Pfister, Sripad, Ram, Purnima, Sundar, Graham, Thomas, Hua, Long, Wenjing, Yang, Shobha, Potluri, Shahram, Salek-Ardakani
Publikováno v:
Journal for Immunotherapy of Cancer
Background Programmed death (ligand) 1 (PD-(L)1) blockade and OX40/4-1BB costimulation have been separately evaluated in the clinic to elicit potent antitumor T cell responses. The precise mechanisms underlying single agent activity are incompletely
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e668 (2007)
The molecular and functional diversity of G protein-coupled receptors is essential to many physiological processes. However, this diversity presents a significant challenge to understanding the G protein-mediated signaling events that underlie a spec
Externí odkaz:
https://doaj.org/article/651effe1cb9b418da36ada77c626fdf2
Autor:
Akihiro Yamanaka, Jessica D. Sun, Pamela Santiago, Ross Bersot, Alex Laihsu, Sarah Black, Paul S. Humphries, Nikki Kimura
Narcolepsy type 1 (Na-1) and 2 (Na-2) are characterized by an inability to sustain wakefulness and are likely caused by degeneration of orexin neurons. Near complete orexin neurodegeneration depletes orexin-A from the cerebrospinal fluid and produces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132dae02e52852f121d964d27f868233
Autor:
Alex Laihsu, Pamela Santiago, Sarah Black, Nikki Kimura, Jessica D. Sun, Paul S. Humphries, Ross Bersot, Kevin D. Donohue, Bruce F. O'Hara
BackgroundAssessment of sleep/wake by electroencephalography (EEG) and electromyography (EMG) is invasive, resource intensive, and not amenable to rapid screening at scale for drug discovery. In the preclinical development of therapeutics for narcole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e9ff98e6cb7e42335aede7447b36c3
https://doi.org/10.1101/226522
https://doi.org/10.1101/226522
Autor:
Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
Publikováno v:
Journal of Medicinal Chemistry. 56:5261-5274
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Akademický článek
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Autor:
Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi
Publikováno v:
Journal of medicinal chemistry. 56(13)
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006