Data from Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor PHA-739358

Autor: Jürgen Moll, Antonella Isacchi, Alexander D. Cameron, Patrizia Carpinelli, Daniele Fancelli, Luisa Rusconi, Rosita Lupi, Riccardo Colombo, Pamela Rosettani, Chiara Soncini, Elena Casale, Michele Modugno

Mutations in the kinase domain of Bcr-Abl are the most common cause of resistance to therapy with imatinib in patients with chronic myelogenous leukemia (CML). Second-generation Bcr-Abl inhibitors are able to overcome most imatinib-resistant mutants,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd319d534851153a0e0e679178e5bf0b
https://doi.org/10.1158/0008-5472.c.6496034

Efficacy and Safety of Extracranial Vein Angioplasty in Multiple Sclerosis

Autor: Paolo, Zamboni, Luigi, Tesio, Stefania, Galimberti, Luca, Massacesi, Fabrizio, Salvi, Roberto, D’Alessandro, Patrizia, Cenni, Roberto, Galeotti, Donato, Papini, Roberto, D’Amico, Silvana, Simi, Maria Grazia Valsecchi, Graziella, Filippini, Group The Brave Dreams Research Group members: Stefano Ceruti, Paolo, Conforti, Anna Maria Malagoni, Erica, Menegatti, Mirko, Tessari, Francesca, Pancaldi, Maria Elena Vanini, Elena, Barbarossa, Ilaria, Bartolomei, Lisa, Pellegrino, Maria Grazia Piscaglia, Fabrizio, Rasi, Maria, Babini, Antonella, Drea, Eugenia, Guerrini, Enrico Maria Lotti, Agnese, Morelli, Milena, Peroni, Valentina, Zalambani, Sauro, Zecchini, Vittorio, Emanuele, Francesco, Patti, Clara, Chisari, Ignazio, Chiaramonte, Vincenzo, Cimino, Alessia, Giaquinta, Luigi Di Pino, Gianni, Failla, Pierfrancesco, Veroux, Roberto, Cantello, Maurizio, Leone, Lorenzo, Coppo, Giuseppe, Guizzardi, Olga, Raymkulova, Simona, Ruggerone, Alessandro, Stecco, Domizia, Vecchio, Paolo Agostino Confalonieri, Angela, Campanella, Valentina, Caldiera, Ciceri, E, Alessandra, Erbetta, Giuseppe, Faragò, Leila, Parma, Barbara, Reggiori, Valentina Torri Clerici, Maura, Danni, Salvatore, Arborino, Fabiana De Berardinis, Laura Di Biagio, Chiara, Orni, Rosita, Renzi, Pamela, Rosettani, Sara, Zagaglia, Giuseppe, Luccioni, Luigi, Oncini, Cristina, Quatrini

Publikováno v: JAMA Neurology. 75:35

Importance Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by restricted venous outflow from the brain and spinal cord. Whether this condition is associated with multiple sclerosis (MS) and whether venous percutaneous transluminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eeec645e315820d92fb93c0022efdbe
https://doi.org/10.1001/jamaneurol.2017.3825

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

Autor: Marina Fasolini, John S. Sack, Herbert E. Klei, Pamela Rosettani, Sandrine Thieffine, Kevin Kish, Jay Bertrand, Ashok V. Purandare, Lata Jayaraman, Tiziano Bandiera, Dianlin Xie, Gerald J. Duke, Sonia Troiani

Publikováno v: The Biochemical journal. 436(2)

CARM1 (co-activator-associated arginine methyltransferase 1) is a PRMT (protein arginine N-methyltransferase) family member that catalyses the transfer of methyl groups from SAM (S-adenosylmethionine) to the side chain of specific arginine residues o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338ca5ad2b222460cd7b3d740aa26e7a
https://pubmed.ncbi.nlm.nih.gov/21410432