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Development of the predictor HERG fluorescence polarization assay using a membrane protein enrichment approach

Autor: Maya Fuerstenau-Sharp, David R. Piper, Steve Duff, Stephen D. Hess, Pam Whitney, Mohammed Saleh Shekhani, C. Jachec, W. Jack Frazee, Hildegard C. Eliason, Kurt W. Vogel, Bryan D. Marks, Elizabeth A. Frey, Brian A. Pollok, David V. Thompson

Publikováno v: Assay and drug development technologies. 6(2)

The life-threatening consequences of acquired, or drug-induced, long QT syndrome due to block of the human ether-a-go-go-related gene (hERG) channel are well appreciated and have been the cause of several drugs being removed from the market in recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cebf6643f4d2882c6f2b5a7fa437fa
https://pubmed.ncbi.nlm.nih.gov/18471075

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Novel Vybrant® DyeCycle ™ Stains Provide Cell Cycle Analysis in Live Cells Using Flow Cytometry with Violet, Blue, and Green Excitation

Autor: Ching-Ying Cheung, William L. Godfrey, Jolene A. Bradford, Stephen Yue, Timothy Huang, Pam Whitney, Patrick R. Pinson

Publikováno v: Blood. 108:4234-4234

Flow cytometric approaches can resolve cell position in the cell cycle based on DNA content, and these analyses are widely used in the study of cell growth, cell cycle regulation, and oncology. These applications require dyes that bind to DNA in a st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7db6c065d6f0fce6ec87b6d9a7a868e8
https://doi.org/10.1182/blood.v108.11.4234.4234

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Akademický článek

USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity.

Autor: Kuang, Xianghong^1,2 (AUTHOR), Salinger, Andrew^1,2 (AUTHOR), Benavides, Fernando^1,2 (AUTHOR), Muller, William J.^3,4,5 (AUTHOR), Dent, Sharon Y. R.^1,2,6 (AUTHOR) sroth@mdanderson.org, Koutelou, Evangelia^1,2 (AUTHOR) sroth@mdanderson.org

Publikováno v: PLoS ONE. 1/18/2024, Vol. 19 Issue 1, p1-19. 19p.

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