Zobrazeno 1 - 10
of 562
pro vyhledávání: '"Pam M"'
Autor:
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Poulson, Garrett E. Casper, Mary L. Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C. Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M. Chow, Max R. Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K. Finch, David Lowe, Asim K. Bera, Gustavo Matute-Bello, Timothy P. Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R. Cochran, Lance J. Stewart, Melody G. Campbell, Pam M. Van Ry, Timothy Springer, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integri
Externí odkaz:
https://doaj.org/article/e3c311aafe5446188603fdc35eee2511
Autor:
Peter N. Ellsworth, Jacob A. Herring, Aaron H. Leifer, Jason D. Ray, Weston S. Elison, Peter Daniel Poulson, Jacqueline E. Crabtree, Pam M. Van Ry, Jeffery S. Tessem
Publikováno v:
Biology, Vol 13, Iss 2, p 110 (2024)
A commonality between type 1 and type 2 diabetes is the decline in functional β-cell mass. The transcription factor Nkx6.1 regulates β-cell development and is integral for proper β-cell function. We have previously demonstrated that Nkx6.1 depends
Externí odkaz:
https://doaj.org/article/acccf53dc7734d41840047ae1c3c5757
Autor:
Kelsey M. Hirschi-Budge, Kary Y. F. Tsai, Katrina L. Curtis, Gregg S. Davis, Benjamin K. Theurer, Anica M. M. Kruyer, Kyle W. Homer, Ashley Chang, Pam M. Van Ry, Juan A. Arroyo, Paul R. Reynolds
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Smoke exposure culminates as a progressive lung complication involving airway inflammation and remodeling. While primary smoke poses the greatest risk, nearly half of the US population is also at risk due to exposure to secondhand
Externí odkaz:
https://doaj.org/article/9b3d3f22ab38421085fb633eb5edd5cf
Autor:
Jose L. Sanchez Noriega, Nicholas A. Chartrand, Jonard Corpuz Valdoz, Collin G. Cribbs, Dallin A. Jacobs, Daniel Poulson, Matthew S. Viglione, Adam T. Woolley, Pam M. Van Ry, Kenneth A. Christensen, Gregory P. Nordin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The ever-growing need for highly functional, compact, and integrated microfluidic devices often incurs lengthy and expensive manufacturing processes. Here, authors introduce a generalized 3D printing process that enables fast parallel fabrication of
Externí odkaz:
https://doaj.org/article/b99f1488a268491db2c0a7428bb4835d
Autor:
Mary L Vallecillo-Zúniga, Matthew F Rathgeber, P Daniel Poulson, Spencer Hayes, Jacob S Luddington, Hailie N Gill, Matthew Teynor, Braden C Kartchner, Jonard Valdoz, Caleb Stowell, Ashley R Markham, Connie Arthur, Sean Stowell, Pam M Van Ry
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238441 (2020)
Limb-girdle muscular dystrophy type 2B (LGMD2B) is caused by mutations in the dysferlin gene, resulting in non-functional dysferlin, a key protein found in muscle membrane. Treatment options available for patients are chiefly palliative in nature and
Externí odkaz:
https://doaj.org/article/1b0d5091b3e842558ddcb01bd5b3fcc0
Autor:
Mary L. Vallecillo-Zúniga, Peter Daniel Poulson, Jacob S. Luddington, Christian J. Arnold, Matthew Rathgeber, Braden C. Kartchner, Spencer Hayes, Hailie Gill, Jonard C. Valdoz, Jonathan L. Spallino, Seth Garfield, Ethan L. Dodson, Connie M. Arthur, Sean R. Stowell, Pam M. Van Ry
Publikováno v:
Cells, Vol 10, Iss 11, p 3210 (2021)
Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair and chronic inflammation, which lead to symptoms of muscle weakness and wasting. Here, we used recombinant human Galectin-1 (rHsGal-1) as a therapeutic
Externí odkaz:
https://doaj.org/article/91776f7c4f7e4124ac9a89b01315ee53
Autor:
Jonard Corpuz Valdoz, Benjamin C. Johnson, Dallin J. Jacobs, Nicholas A. Franks, Ethan L. Dodson, Cecilia Sanders, Collin G. Cribbs, Pam M. Van Ry
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12690 (2021)
The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the field into two distinct areas—scaffold-based and scaffold-free. Scaf
Externí odkaz:
https://doaj.org/article/0c4ddd08bd594566a284b331799c515d
Autor:
Jonard Corpuz Valdoz, Dallin J. Jacobs, Collin G. Cribbs, Benjamin C. Johnson, Brandon M. Hemeyer, Ethan L. Dodson, Jordan A. Saunooke, Nicholas A. Franks, Peter Daniel Poulson, Seth R. Garfield, Connor J. Knight, Pam M. Van Ry
Publikováno v:
Life, Vol 11, Iss 6, p 517 (2021)
Research in fields studying cellular response to surface tension and mechanical forces necessitate cell culture tools with tunability of substrate stiffness. We created a scalable hydrogel dish design to facilitate scaffold-free formation of multiple
Externí odkaz:
https://doaj.org/article/34ede55eb8ba47be8ea258ac5c016f81
Autor:
Brian S. Robinson, Connie M. Arthur, Birk Evavold, Ethan Roback, Nourine A. Kamili, Caleb S. Stowell, Mary L. Vallecillo-Zúniga, Pam M. Van Ry, Marcelo Dias-Baruffi, Richard D. Cummings, Sean R. Stowell
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of infection, wh
Externí odkaz:
https://doaj.org/article/33a7b1c280e54c3fa26b18a729e46e6d
Autor:
Belinda J Gabbe, Pam M Simpson, Peter A Cameron, Jennie Ponsford, Ronan A Lyons, Alex Collie, Mark Fitzgerald, Rodney Judson, Warwick J Teague, Sandra Braaf, Andrew Nunn, Shanthi Ameratunga, James E Harrison
Publikováno v:
PLoS Medicine, Vol 14, Iss 7, p e1002322 (2017)
BackgroundImproved understanding of the quality of survival of patients is crucial in evaluating trauma care, understanding recovery patterns and timeframes, and informing healthcare, social, and disability service provision. We aimed to describe the
Externí odkaz:
https://doaj.org/article/a21c2dc2efb94f60b2792850483b760d