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pro vyhledávání: '"Pam Brauer"'
Autor:
Pam Brauer, Qing Xu, Jingya Ma, Michael E. Bembenek, Jesse Chen, Zhong-Hua Yan, Lawrence R. Dick, Yafang Lin, Khris Garcia, Huay-Keng Loke, Anne L. Burkhardt
Publikováno v:
Analytical Biochemistry. 439:109-115
Cellular effects of a Nedd8-activating enzyme (NAE) inhibitor, MLN4924, using the AlphaScreen format were explored. MLN4924 acts as a substrate-assisted inhibitor of NAE by forming a tight binding Nedd8–MLN4924 adduct. The inhibited enzyme can no l