Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye.

Autor: Shatz W; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., Hass PE; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., Peer N; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., Paluch MT; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., Blanchette C; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., Han G; Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, California, United States of America., Sandoval W; Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, California, United States of America., Morando A; Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America., Loyet KM; Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America., Bantseev V; Safety Assessment, Genentech Inc., South San Francisco, California, United States of America., Booler H; Safety Assessment, Genentech Inc., South San Francisco, California, United States of America., Crowell S; Pre-clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, California, United States of America., Kamath A; Pre-clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, California, United States of America., Scheer JM; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., Kelley RF; Drug Delivery, Genentech, South San Francisco, California, United States of America.

Publikováno v: PloS one [PLoS One] 2019 Jun 28; Vol. 14 (6), pp. e0218613. Date of Electronic Publication: 2019 Jun 28 (Print Publication: 2019).

The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation.

Autor: Martinez-Martin N; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Ramani SR; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Hackney JA; Department of Bioinformatics and Computational Biology, Genentech, 455 East Grand Avenue, South San Francisco, California 94080, USA., Tom I; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Wranik BJ; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Chan M; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Wu J; Department of Bioinformatics and Computational Biology, Genentech, 455 East Grand Avenue, South San Francisco, California 94080, USA., Paluch MT; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Takeda K; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Hass PE; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA., Clark H; Department of Bioinformatics and Computational Biology, Genentech, 455 East Grand Avenue, South San Francisco, California 94080, USA., Gonzalez LC; Department of Protein Chemistry, Genentech, 470 East Grand Avenue, South San Francisco, California 94080, USA.

Publikováno v: Nature communications [Nat Commun] 2016 May 05; Vol. 7, pp. 11473. Date of Electronic Publication: 2016 May 05.