Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Palsamy Periyasamy"'
Publikováno v:
Viruses, Vol 16, Iss 6, p 903 (2024)
Antiretroviral treatments have notably extended the lives of individuals with HIV and reduced the occurrence of comorbidities, including ocular manifestations. The involvement of endoplasmic reticulum (ER) stress in HIV-1 pathogenesis raises question
Externí odkaz:
https://doaj.org/article/608a3cb23e574b0aba5c8f85447224da
Autor:
Seema Singh, Uma Maheswari Deshetty, Sudipta Ray, Abiola Oladapo, Elias Horanieh, Shilpa Buch, Palsamy Periyasamy
Publikováno v:
Cells, Vol 13, Iss 11, p 898 (2024)
NeuroHIV affects approximately 30–60% of people living with HIV-1 (PLWH) and is characterized by varying degrees of cognitive impairments, presenting a multifaceted challenge, the underlying cause of which is chronic, low-level neuroinflammation. S
Externí odkaz:
https://doaj.org/article/97097d4eef934dc68a71b85a6f606baa
Autor:
Muthukumar Kannan, Susmita Sil, Abiola Oladapo, Annadurai Thangaraj, Palsamy Periyasamy, Shilpa Buch
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102689- (2023)
This study was focused on exploring the role of the HIV-1 Tat protein in mediating microglial ferroptosis. Exposure of mouse primary microglial cells (mPMs) to HIV-1 Tat protein resulted in induction of ferroptosis, which was characterized by increas
Externí odkaz:
https://doaj.org/article/fedb065d579546c797b0991b03072eca
Autor:
Howard S. Fox, Meng Niu, Brenda M. Morsey, Benjamin G. Lamberty, Katy Emanuel, Palsamy Periyasamy, Shannon Callen, Arpan Acharya, Gregory Kubik, James Eudy, Chittibabu Guda, Shetty Ravi Dyavar, Courtney V. Fletcher, Siddappa N. Byrareddy, Shilpa Buch
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The twin pandemics of opioid abuse and HIV infection can have devastating effects on physiological systems, including on the brain. Our previous work found that morphine increased the viral reservoir in the brains of treated SIV-infected macaques. In
Externí odkaz:
https://doaj.org/article/bc2b1f24d5e446379cb54f6c41e6b1bb
Autor:
Prakash P. Pillai, Muthukumar Kannan, Susmita Sil, Seema Singh, Annadurai Thangaraj, Ernest T. Chivero, Raghubendra Singh Dagur, Ashutosh Tripathi, Guoku Hu, Palsamy Periyasamy, Shilpa Buch
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4330 (2023)
HIV-1 infection in the era of combined antiretroviral therapy has been associated with premature aging. Among the various features of HIV-1 associated neurocognitive disorders, astrocyte senescence has been surmised as a potential cause contributing
Externí odkaz:
https://doaj.org/article/8c7f8861d2d14015a94b96ad4df822e7
Autor:
Susmita Sil, Annadurai Thangaraj, Abiola Oladapo, Guoku Hu, Naseer A Kutchy, Ke Liao, Shilpa Buch, Palsamy Periyasamy
Publikováno v:
Viruses, Vol 15, Iss 1, p 44 (2022)
Chronic low-grade inflammation remains an essential feature of HIV-1 infection under combined antiretroviral therapy (cART) and contributes to the accelerated cognitive defects and aging in HIV-1 infected populations, indicating cART limitations in s
Externí odkaz:
https://doaj.org/article/fc5e91235d2b49db83194b98306856c2
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15017 (2022)
HIV-1 and drug abuse have been indissolubly allied as entwined epidemics. It is well-known that drug abuse can hasten the progression of HIV-1 and its consequences, especially in the brain, causing neuroinflammation. This study reports the combined e
Externí odkaz:
https://doaj.org/article/f0c0391eda8c40679ab55511b87566ab
Autor:
Annadurai Thangaraj, Ernest T. Chivero, Ashutosh Tripathi, Seema Singh, Fang Niu, Ming-Lei Guo, Prakash Pillai, Palsamy Periyasamy, Shilpa Buch
Publikováno v:
Redox Biology, Vol 44, Iss , Pp 101909- (2021)
Externí odkaz:
https://doaj.org/article/e347b36607e84554840c0379554997e6
Autor:
Annadurai Thangaraj, Ernest T. Chivero, Ashutosh Tripathi, Seema Singh, Fang Niu, Ming-Lei Guo, Prakash Pillai, Palsamy Periyasamy, Shilpa Buch
Publikováno v:
Redox Biology, Vol 40, Iss , Pp 101843- (2021)
The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has not only resulted in a dramatic decrease in the peripheral viral load but has also led to increased life expectancy of the infected individuals. Paradoxical
Externí odkaz:
https://doaj.org/article/ea602c4b91ee4a76b797d7a777779fc6
Autor:
Dinesh Devadoss, Shashi P. Singh, Arpan Acharya, Kieu Chinh Do, Palsamy Periyasamy, Marko Manevski, Neerad Mishra, Carmen S. Tellez, Sundaram Ramakrishnan, Steven A. Belinsky, Siddappa N. Byrareddy, Shilpa Buch, Hitendra S. Chand, Mohan Sopori
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
BackgroundThe role of lung epithelial cells in HIV-1-related lung comorbidities remains unclear, and the major hurdle in curing HIV is the persistence of latent HIV reservoirs in people living with HIV (PLWH). The advent of combined antiretroviral th
Externí odkaz:
https://doaj.org/article/efc67d7b9377436ba6c0338c6d2451dc