A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts.

Autor: Gomez-Cabrero D; Translational Bioinformatics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain., Walter S; Dept. of Medicine and Public Health, Rey Juan Carlos University, Alcorcon, Spain., Abugessaisa I; Dept. of Medicine, Karolinska Institute, Stockholm, Sweden., Miñambres-Herraiz R; Sistemas Genomicos, Valencia, Spain., Palomares LB; Sistemas Genomicos, Valencia, Spain., Butcher L; Department of Biomedical Sciences, Cardiff Metropolitan University, Cardiff, UK., Erusalimsky JD; Department of Biomedical Sciences, Cardiff Metropolitan University, Cardiff, UK., Garcia-Garcia FJ; Dept. of Geriatric Medicine, Complejo Hospitalario Universitario de Toledo (CHUT), Toledo, Spain., Carnicero J; Dept. of Geriatric Medicine, Complejo Hospitalario Universitario de Toledo (CHUT), Toledo, Spain., Hardman TC; Niche Science & Technology Ltd., Richmond-upon-Thames, London, UK., Mischak H; Mosaiques Diagnostics GmbH, Rotenburger Str. 20, 30659, Hannover, Germany., Zürbig P; Mosaiques Diagnostics GmbH, Rotenburger Str. 20, 30659, Hannover, Germany., Hackl M; Evercyte GmbH; BOKU-University of Natural Resources and Life Sciences Vienna, Department of Biotechnology, Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria., Grillari J; Evercyte GmbH; BOKU-University of Natural Resources and Life Sciences Vienna, Department of Biotechnology, Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria., Fiorillo E; Instituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy., Cucca F; Instituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy., Cesari M; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Carrie I; Gérontopôle, Toulouse, France., Colpo M; USL Centro Toscana, Firenze, Italy., Bandinelli S; USL Centro Toscana, Firenze, Italy., Feart C; Univ. Bordeaux, Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France., Peres K; Univ. Bordeaux, Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France., Dartigues JF; Univ. Bordeaux, Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France., Helmer C; Univ. Bordeaux, Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France., Viña J; Freshage, University of Valencia, Valencia, Spain., Olaso G; Freshage, University of Valencia, Valencia, Spain., García-Palmero I; Lifelength, Madrid, Spain., Martínez JG; Lifelength, Madrid, Spain., Jansen-Dürr P; Research Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria., Grune T; German Institute for Human Nutrition, Potsdam, Germany., Weber D; German Institute for Human Nutrition, Potsdam, Germany., Lippi G; Clinical Biochemistry and Molecular Biology, Universita di Verona, Verona, Italy., Bonaguri C; Laboratoy Medicine Technical Sciences, Parma University, Parma, Italy., Sinclair AJ; Diabetes Frail and King's College, London, Se1 8WA, UK., Tegner J; Dept. of Medicine, Karolinska Institute, Stockholm, Sweden.; Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia., Rodriguez-Mañas L; CIBER of Frailty and Healthy Aging, Madrid, Spain. leocadio.rodriguez@salud.madrid.org.; Dept. of Geriatric Medicine, Getafe University Hospital, Getafe, Spain. leocadio.rodriguez@salud.madrid.org.

Publikováno v: GeroScience [Geroscience] 2021 Jun; Vol. 43 (3), pp. 1317-1329. Date of Electronic Publication: 2021 Feb 18.