External Validation of a Predictive Model for Acute Skin Radiation Toxicity in the REQUITE Breast Cohort

Autor: Tim Rattay, Petra Seibold, Miguel E. Aguado-Barrera, Manuel Altabas, David Azria, Gillian C. Barnett, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Charlotte E. Coles, Alison M. Dunning, Rebecca M. Elliott, Marie-Pierre Farcy Jacquet, Sara Gutiérrez-Enríquez, Kerstie Johnson, Anusha Müller, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S. Rosenstein, Dirk De Ruysscher, Maria C. de Santis, Elena Sperk, Hilary Stobart, R. Paul Symonds, Begoña Taboada-Valladares, Ana Vega, Liv Veldeman, Adam J. Webb, Catharine M. West, Riccardo Valdagni, Christopher J. Talbot, REQUITE consortium, Yolande Lievens, Marc van Eijkeren, Piet Ost, Valérie Fonteyne, Christel Monten, Wilfried De Neve, Stephanie Peeters, Karin Haustermans, Caroline Weltens, Gilles Defraene, Maarten Lambrecht, Erik van Limberghen, Erik Briers, Celine Bourgier, Muriel Brengues, Roxana Draghici, Francoise Bons, Thomas Blaschke, Christian Weiß, Irmgard Helmbold, Christian Weißenberger, Petra Stegmaier, Johannes Claßen, Ulrich Giesche, Marie-Luise Sautter-Bihl, Burkhard Neu, Thomas Schnabel, Michael Ehmann, Benjamin Gauter-Fleckenstein, Carsten Herskind, Marlon Veldwijk, Jörg Schäfer, Tommaso Giandini, Marzia Franceschini, Claudia Sangalli, Barbara Avuzzi, Sara Morlino, Laura Lozza, Gabriele Pietro, Elena Delmastro, Elisabetta Garibaldi, Alessandro Cicchetti, Ben Vanneste, Bibiana Piqué-Leiva, Meritxel Molla, Alexandra Giraldo, Monica Ramos, Ramon Lobato-Busto, Paloma Sosa-Fajardo, Laura Torrado Moya, Isabel Dominguez-Rios, Irene Fajardo-Paneque, Patricia Calvo-Crespo, Ana Carballo, Paula Peleteiro, Olivia-Fuentes-Rios, Antonio Gomez-Caamano, Victoria Harrop, Debbie Payne, Manjusha Keni, Samuel Lavers, Simon Wright, Sridhar Thiagarajan, Luis Aznar-Garcia, Kiran Kancherla, Christopher Kent, Subramaniam Vasanthan, Donna Appleton, Monika Kaushik, Frances Kenny, Hazem Khout, Jaroslaw Krupa, Kelly V. Lambert, Simon Pilgrim, Sheila Shokuhi, Kalliope Valassiadou, Ion Bioangiu, Kufre Sampson, Ahmed Osman, Corinne Faivre-Finn, Karen Foweraker, Abigail Pascoe, Claire P. Esler, Tim Ward, Daniel S. Higginson, Richard G. Stock, Sheryl Green

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of this study was to deve

Externí odkaz: https://doaj.org/article/8c6dd513848e4d99a2a71215a83b3a38

No association between polygenic risk scores for cancer and development of radiotherapy toxicity

Autor: Gillian C. Barnett, Sarah L. Kerns, Leila Dorling, Laura Fachal, Miguel E. Aguado-Barrera, Laura Martínez-Calvo, Harkeran K. Jandu, Ceilidh Welsh, Jonathan Tyrer, Charlotte E. Coles, Joanne S. Haviland, Christopher Parker, Antonio Gómez-Caamaño, Patricia Calvo-Crespo, Paloma Sosa-Fajardo, Neil G. Burnet, Holly Summersgill, Adam Webb, Dirk De Ruysscher, Petra Seibold, Jenny Chang-Claude, Christopher J. Talbot, Tim Rattay, Matthew Parliament, Kim De Ruyck, Barry S. Rosenstein, Paul D.P. Pharoah, Alison M. Dunning, Ana Vega, Catharine M.L. West

Publikováno v: International Journal of Radiation Oncology Biology Physics, 114(3), 494-501. Elsevier Science

Purpose: Our aim was to test whether updated polygenic risk scores (PRS) for susceptibility to cancer affect risk of radiation therapy toxicity. Methods and Materials: Analyses included 9,717 patients with breast (n=3,078), prostate (n=5,748) or lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195268f26e7f1840a9e2e97f2c194cb1
https://cris.maastrichtuniversity.nl/en/publications/ead33649-3701-47a7-afcd-c39bc9b00b93

Use of Angiotensin Converting Enzyme Inhibitors is Associated with Reduced Risk of Late Bladder Toxicity Following Radiotherapy for Prostate Cancer

Autor: Sarah L. Kerns, Ashley Amidon Morlang, Sharon M. Lee, Derick R. Peterson, Brian Marples, Hong Zhang, Kevin Bylund, Doug Rosenzweig, William Hall, Kim De Ruyck, Barry S. Rosenstein, Richard G. Stock, Antonio Gómez-Caamaño, Ana Vega, Paloma Sosa-Fajardo, Begoña Taboada-Valladares, Miguel E. Aguado-Barrera, Chris Parker, Liv Veldeman, Valérie Fonteyne, Renée Bultijnck, Christopher J. Talbot, R. Paul Symonds, Kerstie Johnson, Tim Rattay, Adam Webb, Maarten Lambrecht, Dirk de Ruysscher, Ben Vanneste, Ananya Choudhury, Rebecca M. Elliott, Elena Sperk, Carsten Herskind, Marlon R. Veldwijk, Tiziana Rancati, Barbara Avuzzi, Riccardo Valdagni, David Azria, Marie-Pierre Farcy Jacquet, Jenny Chang-Claude, Petra Seibold, Catharine West, Michelle Janelsins, Yuhchyau Chen, Edward Messing, Gary Morrow, Erik Briers, Alison Dunning, Rebecca M Elliott, Sara Gutiérrez-Enríquez, Dirk De Ruysscher, R Paul Symonds, Hilary Stobart, Tim Ward, Catharine M. West

Publikováno v: Radiother Oncol
Radiotherapy and Oncology, 168, 75-82. Elsevier Ireland Ltd

BACKGROUND AND PURPOSE: Genome-wide association studies (GWAS) of late hematuria following prostate cancer radiotherapy identified single nucleotide polymorphisms (SNPs) near AGT, encoding angiotensinogen. We tested the hypothesis that patients takin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0659b0fd46b11059e755f707e529ae5
https://europepmc.org/articles/PMC8986577/

Contributors

Autor: José Francisco Noguera Aguilar, Mohammed Alhayek-Aí, Pedro A. Alonso Aguirre, Paula Álvarez-Chaver, Sara Alvarez-Gonzalez, Lucía Álvarez-Santullano, Javier Castro Alvariño, Jorge Amigo, Luis M. Antón Aparicio, Natalia Aptsiauri, María Sánchez Ares, Begoña Campos Balea, Paula Vieiro Balo, Lucía Barcia, Germán Bou, Vanesa Balboa Barreiro, Isaac Martínez Bendayán, Mónica Bernal, Pedro Carpintero Briones, Elena Brozos-Vázquez, Begoña Bravo Bueno, Alba Burundarena, Antonio Gómez Caamaño, José Manuel Mera Calviño, Marcos Calvo, Sonia Candamio-Folgar, Alejandra Cardelle-Cobas, Ángel Carracedo, Ainhoa Carrasco, Álvaro Gómez Castro, Ana María Carballo Castro, Alberto Cepeda, Alfonso Cepeda-Emiliani, Ángel Concha, Benito González Conde, Oscar J. Cordero, Alberto Centeno Cortés, Jesús Paredes Cotoré, Patricia Calvo Crespo, Alain García de Castro, Loretta De Chiara, Enrique González de la Ballina González, Sofía Rodríguez Martínez de Llano, Manuel Núñez Deben, M. del Carmen Corujeira Rivera, Cristina Méndez Díaz, Sonia Pértega Díaz, Leticia García Diéguez, Antonio Rodríguez D'Jesús, Ramón Vázquez Dourado, Alba Gómez Dovigo, Paloma Sosa Fajardo, Nereida Fernández Fernández, Rafaela Soler Fernández, Rosalía Fernández, Sergio Manuel Estévez Fernández, Carlos Fernandez-Lozano, Ceres Fernández-Rozadilla, Raquel Sardina Ferreiro, Silvia Varela Ferreiro, Roberto García Figueiras, Angélica Figueroa, Lydia Fraga Fontoira, Carlos M.N Franco, María Gallardo-Gómez, Concepción Crespo García, Esther Rodríguez García, Alba García-López, Federico Garrido, Javier Aguirrezabalaga González, Joaquín González-Carreró, Diego Gonzalez-Rivas, Begoña Graña-Suárez, Vicent Hernández, Paula Peleteiro Higuero, Héctor Lázare Iglesias, Orlando Fernández Lago, Alexandre Lamas, Jose Liñares-Blanco, María Jose Martinez-Sapiña Llanas, Fernando Fernández López, José Ramón Antúnez López, Rafael López-López, Anael López-Novo, Carmen Álvarez Lorenzo, Miguel Pereira Loureiro, Ramiro Manuel Macenlle García, Shirly Margarita Nieves Maldonado, Sara Seijas Marcos, Eva Martí Marqués, Cristina González Martín, Arantza Germade Martínez, Nieves Martínez Lago, Gala Martínez-Bernal, Julia Martínez-Pérez, Virginia Mato-Abad, Silvia Louzao Méndez, Manuel Bustamante Montalvo, Beatriz Romero Mosquera, Catuxa Celeiro Muñoz, Cristian R. Munteanu, Ángel Concheiro Nine, Alejandra García Novoa, Martina Lema Oreiro, Francisco Ruíz-Cabello Osuna, María Otero, Susana A. Otero Muinelo, Pilar Díaz Parada, Jesús P. Paredes Cotoré, Alejandro Pazos, Alejandro Pazos García, Carla Pazos García, Nieves Pedreira, María Teresa Seoane Pillado, Susana López Piñeiro, Margarita Poza, Natalia Cal Purriños, Francisco Queipo, Patricia Regal, Fernando Zelaya Reinquet, María Teresa Vázquez Rey, Andrés Dacal Rivas, José Luis Ulla Rocha, Alejandro Ledo Rodríguez, Francisco Javier González Rodríguez, Gerardo Baños Rodríguez, María Teresa García Rodríguez, Máximo Fraga Rodríguez, Miriam Rojas, Leopoldo López Rosés, Marta Covela Rúa, Juan Ruiz-Bañobre, Clara Ruiz-Ponte, Francisco Javier Maestro Saavedra, Víctor Sacristán Santos, Ismael Said-Criado, Aliuska Duardo Sánchez, Paloma González Santamaría, Rodrigo A.S. Sardenberg, Antonio Jurjo Sieira, Paulino Pais Silva, Rosa Fungueiriño Suarez, Tatiana María Civeira Taboada, Adriana Barreiro Trillo, Rosa Trillo, M. Lidia Vázquez-Tunas, Alfonso Martínez Turnes, Begoña Taboada Valladares, Manuel Valladares-Ayerbes, Vanesa Val Varela, Rubén Varela-Calviño, Beatriz I. Vázquez, Carla Blanco Vázquez, Juan Turnes Vázquez, Pablo Parada Vázquez, Vanesa Vilanova Vázquez, José M. Vázquez-Naya, Francisca Vázquez-Rivera, Alberto Veiga, Yolanda Vidal-Ínsua, Alba María Arceo Vilas, Ignacio Couto Worner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec27835176343b678c642ea4f4aa9c4d
https://doi.org/10.1016/b978-0-323-90055-3.09988-9

Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity

Autor: A. Webb, David Azria, Sarah L. Kerns, Karen Foweraker, Ana Carballo, Barbara Avuzzi, Luis Aznar-Garcia, Roxana Draghici, Monica Ramos, Stéphanie Peeters, Benjamin Gauter-Fleckenstein, Daniel S. Higginson, Anna Maria Paganoni, Ulrich Giesche, Monika Kaushik, Corinne Faivre-Finn, Ananya Choudhury, Andrea Manzoni, Jörg Schäfer, Carsten Herskind, Frances Kenny, Paolo Zunino, Valérie Fonteyne, Abigail Pascoe, S. Morlino, Paloma Sosa-Fajardo, Manjusha Keni, Karin Haustermans, A. Giraldo, Jaroslaw Krupa, Claudia Sangalli, Thomas Schnabel, Gert De Meerleer, Yolande Lievens, Patricia Calvo-Crespo, Marie-Pierre Farcy-Jacquet, Petra Seibold, Nicola Rares Franco, Ramón Lobato-Busto, Irene Fajardo-Paneque, Tim Rattay, Ana Vega, Riccardo Valdagni, Elena Delmastro, Irmgard Helmbold, Ben G. L. Vanneste, Richard G. Stock, Donna Appleton, Debbie Payne, Barry S. Rosenstein, Liv Veldeman, Rebecca Elliott, Tiziana Rancati, Alison M. Dunning, Claire P. Esler, Sridhar Thiagarajan, Elisabetta Garibaldi, Muriel Brengues, Michela Carlotta Massi, Simon Pilgrim, Maria C. De Santis, Wilfried De Neve, Miguel E. Aguado-Barrera, Evert J. Van Limbergen, Olivia-Fuentes-Rios, Paul Symonds, Jenny Chang-Claude, Elena Sperk, Catharine M L West, Petra Stegmaier, Antonio Gómez-Caamaño, Marzia Franceschini, Laura Torrado Moya, Simon Wright, Kufre Sampson, Kalliope Valassiadou, Francesca Ieva, Burkhard Neu, Isabel Dominguez-Rios, Francoise Bons, Marie-Luise Sautter-Bihl, Gilles Defraene, Tommaso Giandini, Meritxel Molla, Sheryl Green, Victoria Harrop, Alessandro Cicchetti, Christian Weiß, Caroline Weltens, Gabriele Pietro, Christopher Kent, Michael Ehmann, Paula Peleteiro, Dirk De Ruysscher, Thomas Blaschke, Ion Bioangiu, Hazem Khout, Samuel Lavers, Ahmed Osman, Laura Fachal, Subramaniam Vasanthan, Marc van Eijkeren, Laura Lozza, Céline Bourgier, Kelly Lambert, Johannes Claßen, Piet Ost, Kerstie Johnson, Christian Weißenberger, Bibiana Piqué-Leiva, Timothy H Ward, Christel Monten, Maarten Lambrecht, Marlon R. Veldwijk, Erik van Limberghen, Kiran Kancherla, Christopher J. Talbot, Barbara Noris Chiorda, Erik Briers, Sheila Shokuhi

Publikováno v: RADIOTHERAPY AND ONCOLOGY
Radiotherapy and Oncology, 159, 241-248. Elsevier Ireland Ltd

AIM: To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a7b893793cb9be0c1758ad6b546648
https://lirias.kuleuven.be/handle/20.500.12942/691375