Výsledky vyhledávání - "Paloma Marinho Jucá"

In vitro immunogenic profile of recombinant SARS-CoV2 S1-RBD peptide in murine macrophage and microglial cells

Autor: Adriano José Maia Chaves Filho, Paloma Marinho Jucá, Michelle Verde Ramo Soares, Caio Andrade de Oliveira, Raul Cavalcante de Sousa, Deniele Bezerra Lós, Remo Castro Russo, Juliana Navarro Ueda Yaochite, Danielle S Macedo

Publikováno v: Memórias do Instituto Oswaldo Cruz. 118

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aebc89e719494d3e656b507426b97393
https://doi.org/10.1590/0074-02760220144

Zobrazit plný text záznamu

Recombinant SARS-CoV2 S1-RBD peptide induces a concentration-dependent activation of macrophages and microglia cell lines in vitro

Autor: Adriano Chaves Filho, Paloma Marinho Jucá, Michelle Verde Ramo Soares, Caio Andrade de Oliveira, Raul Cavalcante de Sousa, Deniele Bezerra Lós, Remo Castro Russo, Juliana Navarro Ueda Yaochite, Danielle S. Macedo

Objective: We aimed to characterize the effects of recombinant SARS-CoV-2 S1 receptor-binding domain (RBD) peptide stimulating the macrophage and microglial immune activation compared with classical PAMPs in vitro. Material: Murine RAW 264.7 macropha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::585b3af9e919065935d7e437c038d615
https://doi.org/10.21203/rs.3.rs-1690154/v1

Zobrazit plný text záznamu

Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?

Autor: Michele Verde-Ramo Soares, Alana Gomes de Souza, Adriano José Maia Chaves Filho, Danielle Silveira Macêdo, Tatiana de Queiroz, Paloma Marinho Jucá, Natássia Lopes Cunha, Carolina Horta Andrade, Dino César da Silva Clemente, Melina Mottin, Christina Alves Peixoto, Patrícia de Araújo Rodrigues

Publikováno v: European Neuropsychopharmacology. 42:57-74

Immune-inflammatory mechanisms are involved in the pathophysiology of bipolar disorder. Tetracyclines present neuroprotective actions based on their anti-inflammatory and microglia suppressant effects. Doxycycline (DOXY) is a tetracycline that demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad2758b7f147ee4f94645216768a880
https://doi.org/10.1016/j.euroneuro.2020.11.007

Zobrazit plný text záznamu

Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression

Autor: Adriano José Maia Chaves Filho, Danielle Silveira Macêdo, Antônio Lúcio Teixeira, Viviane de Sousa Tomaz, Rafaela Carneiro Cordeiro, David Freitas de Lucena, Paloma Marinho Jucá, Wei Jiang, Poliana Noronha Barroso, Larissa Maria Frota Cristino, Michelle Verde Ramo Soares

Publikováno v: Journal of Affective Disorders. 268:188-200

Background Depressed patients present increased plasma levels of lipopolysaccharide (LPS) and neuroinflammatory alterations. Here, we determined the neuroimmune effects of different classes of ADs by using the LPS inflammatory model of depression. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2137cb1afc2c2654bb504c26b4c353
https://doi.org/10.1016/j.jad.2020.03.022

Zobrazit plný text záznamu

Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway

Autor: Alana Gomes de Souza, Iardja Stéfane Lopes, Adriano José Maia Chaves Filho, Talita Matias Barbosa Cavalcante, João Victor Souza Oliveira, Michele Albuquerque Jales de Carvalho, Klistenes Alves de Lima, Paloma Marinho Jucá, Sabrina Silva Mendonça, Melina Mottin, Carolina Horta Andrade, Francisca Cléa Florenço de Sousa, Danielle S. Macedo, Marta Maria de França Fonteles

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacologyReferences. 395(9)

We postulated that dimethyl fumarate (DMF), an activator of the Nuclear Factor Erythroid 2-related factor 2 (Nrf2) pathway, exerts neuroprotective effects against depression-like behaviors through astrocytes and microglia modulation. To ascertain our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964f40c0bf35410ca6359167edf084ce
https://pubmed.ncbi.nlm.nih.gov/35665831

Zobrazit plný text záznamu

Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry

Autor: Danielle Silveira Macêdo, Adriano José Maia Chaves Filho, Paloma Marinho Jucá, Carolina Horta Andrade, Melina Mottin, Michele Verde-Ramo Soares

Publikováno v: Behavioural pharmacology. 32(3)

Major mental disorders, such as schizophrenia, bipolar disorder, and major depressive disorder, represent the leading cause of disability worldwide. Nevertheless, the current pharmacotherapy has several limitations, and a large portion of patients do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ff3341d58adeec1d210272df40beb3
https://pubmed.ncbi.nlm.nih.gov/33595954

Zobrazit plný text záznamu

Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression

Autor: Natássia Lopes Cunha, Tatiana de Queiroz Oliveira, Michelle Verde Ramos Soares, Paloma Marinho Jucá, Charliene Freire Xavier Vieira, Silvânia Maria Mendes Vasconcelos, Adriano José Maia Chaves Filho, Gabriela Mariângela Farias de Oliveira, Danielle Silveira Macêdo, Carlos Venício Jatai Gadelha Filho, Glautemberg de Almeida Viana

Publikováno v: Behavioural Brain Research. 419:113667

Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain. Thus, the present study aimed to test the effects of the neurop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de52dff0e93d3ad70ac45eb4fba655c
https://doi.org/10.1016/j.bbr.2021.113667

Zobrazit plný text záznamu

The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder

Autor: Danielle Silveira Macêdo, Alana Gomes de Souza, Tatiana de Queiroz, Paloma Marinho Jucá, Samira S. Valvassori, David Freitas de Lucena, Adriano José Maia Chaves Filho, Natássia Lopes Cunha, Michele Verde-Ramo Soares, João Victor Souza Oliveira, Tatiana Barichello, João Quevedo

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 99:109872

Metabolic and psychiatric disorders present a bidirectional relationship. GLP-1 system, known for its insulinotropic effects, has also been associated with numerous regulatory effects in cognitive and emotional processing. GLP-1 receptors (GLP-1R) ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc7bce422c76c1d3bab045cc0749409
https://doi.org/10.1016/j.pnpbp.2020.109872

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání