Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Paloma García-Casas"'
Autor:
Paloma García-Casas, Pilar Alvarez-Illera, Eva Gómez-Orte, Juan Cabello, Rosalba I. Fonteriz, Mayte Montero, Javier Alvarez
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We have reported recently that the mitochondrial Na+/Ca2+ exchanger inhibitor CGP37157 extends lifespan in Caenorhabditis elegans by a mechanism involving mitochondria, the TOR pathway and the insulin/IGF1 pathway. Here we show that CGP37157 signific
Externí odkaz:
https://doaj.org/article/8861bf1cb92c4462aad7829784446e20
Publikováno v:
Cells, Vol 10, Iss 8, p 2133 (2021)
Calcium (Ca2+) signaling coordinates are crucial processes in brain physiology. Particularly, fundamental aspects of neuronal function such as synaptic transmission and neuronal plasticity are regulated by Ca2+, and neuronal survival itself relies on
Externí odkaz:
https://doaj.org/article/68d9e4f4e47d464cbfcc5b3c9cd1858f
Publikováno v:
Cells, Vol 10, Iss 8, p 1968 (2021)
Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer’s disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid p
Externí odkaz:
https://doaj.org/article/a3ea3bc2cd3f4858ba78c6ab9729e865
Autor:
Paloma García-Casas, Jessica Arias-del-Val, Pilar Alvarez-Illera, Aneta Wojnicz, Cristobal de los Ríos, Rosalba I. Fonteriz, Mayte Montero, Javier Alvarez
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2019)
The benzothiazepine CGP37157 has shown neuroprotective effects in several in vitro models of excitotoxicity involving dysregulation of intracellular Ca2+ homeostasis. Although its mechanism of neuroprotection is unclear, it is probably related with s
Externí odkaz:
https://doaj.org/article/f9c674026ffb44bab9921431a65183c6
Autor:
Paloma García Casas, Michela Rossini, Linnea Påvénius, Mezida Saeed, Nikita Arnst, Sonia Sonda, Tânia Fernandes, Irene D’Arsiè, Matteo Bruzzone, Valeria Berno, Andrea Raimondi, Maria Livia Sassano, Luana Naia, Elisa Barbieri, Sara Sigismund, Patrizia Agostinis, Mattia Sturlese, Barbara A. Niemeyer, Hjalmar Brismar, Maria Ankarcrona, Arnaud Gautier, Paola Pizzo, Riccardo Filadi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites and their small size hinder analysis by current imaging techniques. To overcome these limitations, we h
Externí odkaz:
https://doaj.org/article/0b6b5bb0acb9468497829472faf67a2f
Autor:
Javier Alvarez, Pilar Alvarez-Illera, Paloma García-Casas, Rosalba I. Fonteriz, Mayte Montero
Publikováno v:
Cells, Vol 9, Iss 1, p 204 (2020)
Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation. There is ample evidence that the dysregulation of Ca2+ signaling
Externí odkaz:
https://doaj.org/article/57c7a0f3107c42e1a99ec7c6fa83f128
Autor:
Paloma García-Casas, Jessica Arias-del-Val, Pilar Alvarez-Illera, Rosalba I. Fonteriz, Mayte Montero, Javier Alvarez
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) refills the endoplasmic reticulum (ER) with Ca2+ up to the millimolar range and is therefore the main controller of the ER [Ca2+] level ([Ca2+]ER), which has a key role in the modulation of cytosoli
Externí odkaz:
https://doaj.org/article/4d5a6bee3c524d20a10579c714e2b289
Publikováno v:
Cells
Volume 10
Issue 8
Cells, Vol 10, Iss 1968, p 1968 (2021)
Volume 10
Issue 8
Cells, Vol 10, Iss 1968, p 1968 (2021)
Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer’s disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef337e13952db55a7b71a01308ba53dc
Autor:
Paloma García-Casas, Rosalba I. Fonteriz, Mayte Montero, Pilar Alvarez-Illera, Javier Alvarez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
We have reported recently that submaximal inhibition of the Sarco Endoplasmic Reticulum Ca2+ ATPase (SERCA) produces an increase in the lifespan of C. elegans worms. We have explored here the mechanism of this increased survival by studying the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12806110e681e43661c7fb447a42f03f
http://hdl.handle.net/10261/260807
http://hdl.handle.net/10261/260807
Autor:
Andreas Wiederkehr, Jessica Arias-del-Val, Rosalba I. Fonteriz, Javier Alvarez, Antonio Núñez Galindo, Pilar Alvarez-Illera, Mayte Montero, Paloma García-Casas, Jaime Santo-Domingo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The 5' AMP-activated protein kinase (AMPK) is a nutrient-sensitive kinase that plays a key role in the control of cellular energy metabolism. We have explored here the relationship between AMPK and Ca2+ signaling by looking at the effect of an AMPK a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bead052b00025abcc5449fdc358a1192
https://doi.org/10.1016/j.ceca.2018.12.004
https://doi.org/10.1016/j.ceca.2018.12.004