Integrating metabolome dynamics and process data to guide cell line selection in biopharmaceutical process development

Autor: Gianmarco Barberi, Antonio Benedetti, Paloma Diaz-Fernandez, Daniel C. Sévin, Johanna Vappiani, Gary Finka, Fabrizio Bezzo, Massimiliano Barolo, Pierantonio Facco

The successful development of mammalian cell culture for the production of therapeutic antibodies is a resource-intensive and multistage process which requires the selection of high performing and stable cell lines at different scale-up stages. Accor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609e64f7160f9655d56ead9b1c40382e
http://hdl.handle.net/11577/3452299

Spectroscopy integration to miniature bioreactors and large scale production bioreactors-Increasing current capabilities and model transfer

Autor: Gary Finka, Alexander Graf, Angus Woodhams, Robert Soeldner, Steve R. C. Warr, Marek Hoehse, Paloma Diaz-Fernandez, Ruth C. Rowland-Jones

Publikováno v: Biotechnology progressREFERENCES. 37(1)

Spectroscopy techniques are being implemented within the biopharmaceutical industry due to their non-destructive ability to measure multiple analytes simultaneously, however, minimal work has been applied focussing on their application at small scale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3155717ab3d6a116b499c1af3a37389
https://pubmed.ncbi.nlm.nih.gov/32865874

Structure of Be13 studied in proton knockout from B14

Autor: Roy Crawford Lemmon, C. Wimmer, U. Datta Pramanik, K. Goebel, I. Syndikus, Nasser Kalantar-Nayestanaki, C. Wheldon, Enrique Nácher, Thomas Aumann, J. S. Winfield, Andreas Martin Heinz, N. Kurz, L. M. Fraile, Hans Geissel, Rene Reifarth, Mikhail V. Zhukov, J. Marganiec, E. Cravo, P. Velho, M. Heine, M. Caamaño, M. Roeder, O. Ershova, Alfredo Estrade, Martin Freer, Daniel Bemmerer, G. L. Wilson, P. J. Woods, S. Pietri, Z. Elekes, G. Ribeiro, Björn Jonson, J. M. Boillos, Joakim Cederkäll, J. Taylor, J. Hagdahl, Herbert A. Simon, Paloma Diaz Fernandez, T. Kroell, Andreas Wagner, Matthias Heil, R. Crespo, A. Ignatov, M. J. G. Borge, K. Riisager, Roman Gernhaeuser, K. Boretzky, A. Movsesyan, Andreas Zilges, Carlos A. Bertulani, A. Hufnagel, H. O. U. Fynbo, A. Kelic-Heil, V. Panin, T. Le Bleis, Christoph Langer, D. Cortina-Gil, L. Atar, E. Casarejos, R. Thies, Jorge Machado, Joachim Enders, Olof Tengblad, Marina Petri, Ralf Plag, J. Benlliure, Deniz Savran, D. M. Rossi, Marielle Chartier, C. Caesar, Y. Aksyutina, Simon Lindberg, Catherine Rigollet, L. V. Chulkov, Daniel Galaviz, M. Holl, O. Sorlin, C. Nociforo, Helmut Weick, Håkan T Johansson, H. Scheit, W. N. Catford, Ángel Perea, Vladimir Avdeichikov, I. Dillmann, Pavel Golubev, F. Farinon, Stefanos Paschalis, H. Alvarez-Pol, R. Kanungo, Marine Vandebrouck, Kai Zuber, M. Labiche, A. Henriques, S. Beceiro-Novo, Thomas Nilsson, F. Wamers, Tanja Heftrich

Publikováno v: Physical Review C. 98

The neutron-unbound isotope Be-13 has been studied in several experiments using different reactions, different projectile energies, and different experimental setups. There is, however, no real consensus in the interpretation of the data, in particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::741a73c6fcf236f398645eda76981998
https://doi.org/10.1103/physrevc.98.024603

La dictadura de Primo de Rivera : una oportunidad para la mujer

Autor: Paloma Díaz Fernández

Publikováno v: Espacio, Tiempo y Forma. Serie V, Historia Contemporánea, Vol 0, Iss 17 (2005)

A través de este artículo se ha tratado de explicar la importancia de la participación femenina en las instituciones y organismos de carácter político durante la Dictadura de Primo de Rivera y su significación en la consecución de los derect)o

Externí odkaz: https://doaj.org/article/1709c0a70770498ba6dfd624de979a48