Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment

Autor: Paloma Begines, Sergio Martos, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños

Publikováno v: Molecules, Vol 27, Iss 4, p 1315 (2022)

Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the preparation of novel hybrids, combining both pharmacophores in order to obtain new antioxidant and antiproliferative agents. Three

Externí odkaz: https://doaj.org/article/0ea4079c0cc74c9ab4e6938c6ac1fb85

Natural Deep Eutectic Solvent Extraction of Flavonoids of Scutellaria baicalensis as a Replacement for Conventional Organic Solvents

Autor: Wim Wouter Oomen, Paloma Begines, Natali Rianika Mustafa, Erica G. Wilson, Robert Verpoorte, Young Hae Choi

Publikováno v: Molecules, Vol 25, Iss 3, p 617 (2020)

Natural deep eutectic solvents (NADES) are a type of ionic liquid (IL) or deep eutectic solvent (DES), the ingredients of which are exclusively natural products (non-toxic and environmentally friendly). Here, we explore the potential of NADES as an a

Externí odkaz: https://doaj.org/article/55f2cc8fdc694bad9e7cf81aa94e52e5

Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance

Autor: José G. Fernández-Bolaños, Óscar López, Inés Maya, Samuel Bayort, Rebecca Puckett, Adrián Puerta, Paloma Begines, José M. Padrón, Lucía Sevilla-Horrillo, Irene Lagunes

Publikováno v: Pharmaceuticals
Volume 13
Issue 11
Pharmaceuticals, Vol 13, Iss 358, p 358 (2020)
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname

Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number of cytotoxic agents developed so far, good therapeutic approaches are not always reached. In recent years, multitarget drugs are g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23951c403ba7c825c8c1f50a80b3c787

Chalcogen-containing phenolics as antiproliferative agents

Autor: Paloma Begines, Gabriela B. Plata, José G. Fernández-Bolaños, Inés Maya, Ana Oliete, José M. Padrón, Óscar López

Publikováno v: Future Medicinal Chemistry. 10:319-334

Aim: The increasing number of cancer cases has stimulated researchers to seek for novel approaches. We have combined two bioactive moieties: a polyphenolic scaffold and an organoselenium motif. Four different families (isothiocyanates/thioureas, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7737b28adcf2275634c75f718d929881
https://doi.org/10.4155/fmc-2017-0053

Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations

Autor: Adrián Puerta, Inés Maya, Miguel X. Fernandes, Alexis R. Galán, José M. Padrón, Irene Lagunes, Paloma Begines, Óscar López, Adrián Silva, José G. Fernández-Bolaños

Publikováno v: European journal of medicinal chemistry. 179

Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin skeleton and an organoselenium motif. Three families were obtained: isoselenocyanate, selenocarbamates and selenoureas. The main p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a612e68fd7edc70cac4f7025070a3bc6
https://pubmed.ncbi.nlm.nih.gov/31271961