Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation

Autor: Madhur Shetty, Danielle E. Bolland, Joshua Morrell, Bryon D. Grove, James D. Foster, Roxanne A. Vaughan

Publikováno v: Current Research in Physiology, Vol 6, Iss , Pp 100106- (2023)

The primary regulator of dopamine availability in the brain is the dopamine transporter (DAT), a plasma membrane protein that drives reuptake of released dopamine from the extracellular space into the presynaptic neuron. DAT activity is regulated by

Externí odkaz: https://doaj.org/article/2cd3ce10da6d4b5ab18d57d3cadadfb7

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Global Analysis of Apicomplexan Protein S‐Acyl Transferases Reveals an Enzyme Essential for Invasion

Autor: Julian C. Rayner, Karine Frénal, Yonggen Jia, Oliver Billker, Christina Mueller, Dominique Soldati-Favre, Ellen Bushell, Chwen L. Tay, Arnault Graindorge

Publikováno v: Traffic; Vol 14
Traffic (Copenhagen, Denmark)
Traffic, Vol. 14, No 8 (2013) pp. 895-911
Traffic

The advent of techniques to study palmitoylation on a whole proteome scale has revealed that it is an important reversible modification that plays a role in regulating multiple biological processes. Palmitoylation can control the affinity of a protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a5754621c9f3a7a61058380e50fe34
https://doi.org/10.1111/tra.12081

Functional dissection of molecular mechanisms underlying host invasion and replication in the obligate intracellular pathogen Toxoplasma gondii

Autor: Beck, Joshua Ryan

Publikováno v: Beck, Joshua Ryan. (2012). Functional dissection of molecular mechanisms underlying host invasion and replication in the obligate intracellular pathogen Toxoplasma gondii. UCLA: Microbiology, Immunology, & Molecular Genetics 0440. Retrieved from: http://www.escholarship.org/uc/item/9hr4p098

Apicomplexans are a large group of obligate intracellular parasites including Plasmodium falciparum, the causative agent of human malaria, and Toxoplasma gondii, an important pathogen of immunocompromised individuals. T. gondii is capable of replicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6da17d7b803a878fe12ad92254004a07
http://www.escholarship.org/uc/item/9hr4p098

Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway

Autor: Jose L. Daniotti, Alejandra Trenchi, Guillermo A. Gomez

Publikováno v: The Biochemical journal. 421(3)

GAP-43 (growth-associated protein-43) is it dually palmitoylated protein, at cysteine residues at positions 3 and 4, that mostly localizes in plasma membrane both in neural and non-neural cells. In the present study, we have examined membrane associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d353c44417ba95ee57f5a87011403a9
https://pubmed.ncbi.nlm.nih.gov/19442238