Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Palmarisa Franchetti"'
Autor:
Livio Luongo, Riccardo Petrelli, Luisa Gatta, Catia Giordano, Francesca Guida, Patrizia Vita, Palmarisa Franchetti, Mario Grifantini, Vito de Novellis, Loredana Cappellacci, Sabatino Maione
Publikováno v:
Molecules, Vol 17, Iss 12, Pp 13712-13726 (2012)
This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of human adenosine A1 receptor, on thermal hyperalgesia and mechanical allodynia in a mouse
Externí odkaz:
https://doaj.org/article/84b1afccbd9e45239997541cf1cd33e4
Autor:
Daniel J. Wilson, Loredana Cappellacci, Riccardo Petrelli, Krzysztof Felczak, Patrizia Vita, Palmarisa Franchetti, Ilaria Torquati
Publikováno v:
Recent Patents on Anti-Cancer Drug Discovery. 8:103-125
Inosine monophosphate dehydrogenase (IMPDH), an NAD-dependent enzyme that controls de novo synthesis of guanine nucleotides, has received considerable interest in recent years as an important target enzyme, not only for the discovery of anticancer dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a12daa0b69723e04789bbcf9e31666
https://doi.org/10.2174/1574892811308020001
https://doi.org/10.2174/1574892811308020001
Autor:
Palmarisa Franchetti, Vito de Novellis, Loredana Cappellacci, Patrizia Vita, Riccardo Petrelli, Catia Giordano, Francesca Guida, L. Luongo, Sabatino Maione, Mario Grifantini, Luisa Gatta
Publikováno v:
Molecules; Volume 17; Issue 12; Pages: 13712-13726
Molecules
Molecules
This study was undertaken in order to investigate the effect of chronic treatment with 5#8242;-chloro-5#8242;-deoxy-(#177;)-ENBA, a potent and highly selective agonist of human adenosine A(1) receptor, on thermal hyperalgesia and mechanical allodynia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2df52c056da9e23aa05dc773280ead5
https://doi.org/10.3390/molecules171213712
https://doi.org/10.3390/molecules171213712
Autor:
Mohineesh Kumar, Loredana Cappellacci, Palmarisa Franchetti, Riccardo Petrelli, Bingsen Zhou, Mario Grifantini, Yun Yen, Praveen Kusumanchi, Patrizia Vita, Hiremagalur N. Jayaram
Publikováno v:
European Journal of Medicinal Chemistry. 46:1499-1504
A series of N6-aminopurine-9-β- d -ribonucleosides and ribose-modified 3′-C-methyl analogues substituted at N6-position with a small group like hydroxy, methoxy or amino group or at C2(N6) position have been synthesized and tested against a panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c931f278ea2e5cbc61280035ac47fce
https://doi.org/10.1016/j.ejmech.2011.01.055
https://doi.org/10.1016/j.ejmech.2011.01.055
Autor:
Palmarisa Franchetti, Flavio Cimadamore, Leonardo Sorci, Stefania Scotti, Riccardo Petrelli, Loredana Cappellacci, Giulio Magni, G. Orsomando
Publikováno v:
Biochemistry. 46:4912-4922
Initial-rate and product inhibition studies revealed distinctive ordered ternary complex kinetic mechanisms, substrate specificities, and metal ion preferences for the three isozymes of human nicotinamide mononucleotide adenylyl-transferase (NMNAT, E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91060701cbce16d4c28b5023c0ec7e3
https://doi.org/10.1021/bi6023379
https://doi.org/10.1021/bi6023379
Autor:
Sabatino Maione, Karl-Norbert Klotz, Mario Grifantini, Loredana Cappellacci, Sonja Kachler, Palmarisa Franchetti, Ettore Novellino, Riccardo Petrelli, Antonio Lavecchia, Ilaria Torquati, Livio Luongo
A series of N(6)-substituted-5'-C-(2-ethyl-2H-tetrazol-5-yl)-adenosine and 2-chloro-adenosine derivatives was synthesized as novel, highly potent dual acting hA1AR agonists and hA3AR antagonists, potentially useful in the treatment of glaucoma and ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2a745573dac60533b2cc0424acab64
http://hdl.handle.net/11581/369386
http://hdl.handle.net/11581/369386
Autor:
Palmarisa Franchetti, Loredana Cappellacci, M. Pasqualini, Patrizia Vita, Hiremagalur N. Jayaram, Mario Grifantini, Riccardo Petrelli
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:2023-2027
Synthesis, conformational analysis and antitumor evaluation of 2'- and 3'-C-methyl analogues of mizoribine (bredinine, 4-carbamoyl-1-beta-D-ribofuranosylimidazole-5-olate) are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72146a15bf9d69ecb420674f35f021ca
https://doi.org/10.1080/15257770500334673
https://doi.org/10.1080/15257770500334673
Autor:
Donald B. Boyd, Hiremagalur N. Jayaram, Riccardo Petrelli, Loredana Cappellacci, Palmarisa Franchetti, M. Pasqualini, Vetrichelvan Jayaprakasan, Mario Grifantini, Manojkumar D. Jain
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2045-2053
Thiazole-4-carboxamide adenine dinucleotide (TAD) analogues T-2'-MeAD (1) and T-3'-MeAD (2) containing, respectively, a methyl group at the ribose 2'-C-, and 3'-C-position of the adenosine moiety, were prepared as potential selective human inosine mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dffa055f86872b845e93a8d7b1359b4
https://doi.org/10.1016/j.bmc.2005.01.007
https://doi.org/10.1016/j.bmc.2005.01.007
Autor:
Mario Grifantini, Karl-Norbert Klotz, Patrizia Vita, Palmarisa Franchetti, Claudia Martini, Antonio Lavecchia, Loredana Cappellacci, Barbara Costa, Ettore Novellino, M. Pasqualini, Riccardo Petrelli
Publikováno v:
Journal of Medicinal Chemistry. 48:1550-1562
A number of 3'-C-methyl analogues of selective adenosine receptor agonists such as CPA, CHA, CCPA, 2'-Me-CCPA, NECA, and IB-MECA was synthesized to further investigate the subdomain of the receptor that binds the ribose moiety of the ligands. Affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f2a13e636613050de836e3bd342781
https://doi.org/10.1021/jm049408n
https://doi.org/10.1021/jm049408n
Autor:
Adriaan P. IJzerman, Palmarisa Franchetti, Alessandro Dalpiaz, Barbara Pavan, Françoise Ngo Ngos
Publikováno v:
European Journal of Pharmacology. 448:123-131
The 2-amino-benzoylthiophene derivatives LUF 5468 [(2-amino-4-ethyl-5-methyl-3-thienyl)[3-(trifluoromethyl)phenyl]methanone] and LUF 5484 [(2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(3,4-dichlorophenyl)methanone] have been shown to allosterical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c427a40aea1e1d27595939b4d6f99ab
https://doi.org/10.1016/s0014-2999(02)01982-9
https://doi.org/10.1016/s0014-2999(02)01982-9