Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.

Autor: Noch EK; Division of Neuro-oncology, Department of Neurology, Weill Cornell Medicine, New York, New York, USA.; Sandra and Edward Meyer Cancer Center, Weill Department of Medicine, New York, New York, USA., Palma LN; Sandra and Edward Meyer Cancer Center, Weill Department of Medicine, New York, New York, USA., Yim I; Sandra and Edward Meyer Cancer Center, Weill Department of Medicine, New York, New York, USA., Bullen N; Sandra and Edward Meyer Cancer Center, Weill Department of Medicine, New York, New York, USA., Qiu Y; Department of Population Health Sciences, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, New York, USA., Ravichandran H; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, USA., Kim J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, USA., Rendeiro A; Research Center for Molecular Medicine of the Austrian Academy of Sciences, Medical University of Vienna, Vienna, Austria., Davis MB; Department of Surgery, Weill Cornell Medicine, New York, New York, USA., Elemento O; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, USA., Pisapia DJ; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA., Zhai K; Division of Neuro-oncology, Department of Neurology, Weill Cornell Medicine, New York, New York, USA., LeKaye HC; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Koutcher JA; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Wen PY; Dana Farber Cancer Institute, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Center for Neuro-oncology, Boston, Massachusetts, USA., Ligon KL; Dana Farber Cancer Institute, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Pathology, Boston, Massachusetts, USA., Cantley LC; Dana Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Neuro-oncology [Neuro Oncol] 2023 Dec 08; Vol. 25 (12), pp. 2165-2176.