Human calmodulin mutations cause arrhythmia and affect neuronal function in C. elegans

Autor: Helene H Jensen, Magnus T Frantzen, Jonas L Wesseltoft, Ana-Octavia Busuioc, Katrine V Møller, Malene Brohus, Palle R Duun, Mette Nyegaard, Michael T Overgaard, Anders Olsen

Publikováno v: Jensen, H H, Frantzen, M T, Wesseltoft, J L, Busuioc, A-O, Møller, K V, Brohus, M, Duun, P R, Nyegaard, M, Overgaard, M T & Olsen, A 2023, ' Human calmodulin mutations cause arrhythmia and affect neuronal function in C. elegans ', Human Molecular Genetics, vol. 32, no. 12, pp. 2068-2083 . https://doi.org/10.1093/hmg/ddad042

In humans, mutations in calmodulin cause cardiac arrhythmia. These mutations disrupt the ability of calmodulin to sense calcium concentrations and correctly regulate two central calcium channels, together obstructing heart rhythm. This correlation is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4837815c9d4ef743867e7c994f347a
https://doi.org/10.1093/hmg/ddad042