Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.

Autor: Maillard MC; CHDI Management, Inc., 6080 Center Drive Suite 100, Los Angeles, CA 90045, USA. michel.maillard@chdifoundation.org, Brookfield FA, Courtney SM, Eustache FM, Gemkow MJ, Handel RK, Johnson LC, Johnson PD, Kerry MA, Krieger F, Meniconi M, Muñoz-Sanjuán I, Palfrey JJ, Park H, Schaertl S, Taylor MG, Weddell D, Dominguez C

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2011 Oct 01; Vol. 19 (19), pp. 5833-51. Date of Electronic Publication: 2011 Aug 16.