Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

Autor: Arjen J. Jakobi, Stefan T. Huber, Simon A. Mortensen, Sebastian W. Schultz, Anthimi Palara, Tanja Kuhm, Birendra Kumar Shrestha, Trond Lamark, Wim J. H. Hagen, Matthias Wilmanns, Terje Johansen, Andreas Brech, Carsten Sachse

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

PB1-mediated oligomerization of p62/SQSTM1 is essential for its function as a selective autophagy receptor. Here the authors present the cryo-EM structures of human and Arabidopsis PB1 domain helical assemblies and find that a conserved double argini

Externí odkaz: https://doaj.org/article/3681d17d79a54c59a34880abff981baa

Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

Autor: Anne-Claire Jacomin, Stavroula Petridi, Marisa Di Monaco, Zambarlal Bhujabal, Ashish Jain, Nitha C. Mulakkal, Anthimi Palara, Emma L. Powell, Bonita Chung, Cleidiane Zampronio, Alexandra Jones, Alexander Cameron, Terje Johansen, Ioannis P. Nezis

Publikováno v: Cell Reports, Vol 31, Iss 8, Pp - (2020)

Summary: Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understoo

Externí odkaz: https://doaj.org/article/4c659952edc443cfb7875849b87d2315

SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components

Autor: Abudu, Yakubu Princely, Shrestha, Birendra Kumar, Zhang, Wenxin, Palara, Anthimi, Brenne, Hanne Britt, Larsen, Kenneth Bowitz, Wolfson, Deanna, Dumitriu, Gianina, Øie, Cristina Ionica, Ahluwalia, Balpreet Singh, Levy, Gahl, Behrends, Christian, Tooze, Sharon A, Mouilleron, Stephane, Lamark, Trond, Johansen, Terje

Publikováno v: Abudu YP, Shrestha BK, Zhang W, Palara A, Brenne HB, Larsen KBL, Wolfson DL, Dumitriu GA, Øie CI, Ahluwalia BS, Levy G, Behrends C, Tooze SA, Mouilleron S, Lamark T, Johansen T. SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. Jo

Externí odkaz: https://hdl.handle.net/10037/24143

Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

Autor: Jacomin, Anne-Claire, Petridi, Stavroula, Di Monaco, Marisa, Bhujabal, Zambarlal, Jain, Ashish, Mulakkal, Nitha C., Palara, Anthimi, Powell, Emma L., Chung, Bonita, Zampronio, Cleidiane, Jones, Alexandra, Cameron, Alexander, Johansen, Terje, Nezis, Ioannis P.

Publikováno v: Jacomin, Petridi, Di Monaco, Bhujabal, Jain, Mulakkal, Palara, Powell, Chung, Zampronio, Jones, Cameron, Johansen, Nezis. Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila. Cell reports. 2020;31(8):e1-e4

Externí odkaz: https://hdl.handle.net/10037/20321

Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

Autor: Cleidiane G. Zampronio, Anne-Claire Jacomin, Zambarlal Bhujabal, Ashish Jain, Stavroula Petridi, Alexander D. Cameron, Anthimi Palara, Terje Johansen, Nitha C. Mulakkal, Ioannis P. Nezis, Emma L. Powell, Bonita Chung, Alexandra M. E. Jones, Marisa Di Monaco

Publikováno v: Cell Reports
Cell Reports, Vol 31, Iss 8, Pp-(2020)

Summary Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3998577afee40ad6343e189cae45ae
http://hdl.handle.net/10852/82031