Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Palanivel Kandasamy"'
Autor:
Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol‐Giménez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2782-2800 (2021)
Oncogenic KRAS mutations develop unique metabolic dependencies on nutrients to support tumor metabolism and cell proliferation. In particular, KRAS mutant cancer cells exploit amino acids (AAs) such as glutamine and leucine, to accelerate energy meta
Externí odkaz:
https://doaj.org/article/b6fc7ae16925449f8d9d9da78bd65412
Autor:
Damian T. Nydegger, Jonai Pujol-Giménez, Palanivel Kandasamy, Bruno Vogt, Matthias A. Hediger
Publikováno v:
Viruses, Vol 15, Iss 7, p 1432 (2023)
As the COVID-19 pandemic progresses, new variants of SARS-CoV-2 continue to emerge. This underscores the need to develop optimized tools to study such variants, along with new coronaviruses that may arise in the future. Such tools will also be instru
Externí odkaz:
https://doaj.org/article/361b3b779b334dd38385edaad36bf202
Autor:
Rajesh Bhardwaj, Bartłomiej S. Augustynek, Ebru Ercan-Herbst, Palanivel Kandasamy, Matthias Seedorf, Christine Peinelt, Matthias A. Hediger
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 2, Pp 252-270 (2020)
Externí odkaz:
https://doaj.org/article/849fcf9fda36415285c2f661c862b70e
Autor:
Ponnurengam Malliappan Sivakumar, Siva Chidambaram, Devanand Venkatasubbu, Sugumaran Abimanyu, Palanivel Kandasamy, Sathish K. Perumal
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 20:1300-1310
Breast cancer is the second most common cancer that causes death among women worldwide. Incidence of breast cancer is increasing worldwide, and the age at which breast cancer develops has shifted from 50- 70 years to 30-40 years. Chemotherapy is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499b9c88fb5f389e881d0926eef00ff8
https://doi.org/10.2174/1871520619666191022175003
https://doi.org/10.2174/1871520619666191022175003
Autor:
Matthias Sallinger, Gabriel J. Klesse, Rajesh Bhardwaj, Giuseppe Albano, Gergely Gyimesi, Jan Dernič, Bartłomiej Augustynek, Irene Frischauf, Daniel Guido Fuster, Herwig Grabmayr, Christine Peinelt, Matthias A. Hediger, Palanivel Kandasamy
In humans, there are three paralogs of the Orai Ca2+ channel, which lie at the heart of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still being actively investigated, several artific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b9884fcad11cc3916d11c66792d13e
https://doi.org/10.1101/2021.10.26.465861
https://doi.org/10.1101/2021.10.26.465861
Autor:
Bartłomiej Augustynek, Gergely Gyimesi, Jan Dernič, Matthias Sallinger, Giuseppe Albano, Gabriel J. Klesse, Palanivel Kandasamy, Herwig Grabmayr, Irene Frischauf, Daniel G. Fuster, Christine Peinelt, Matthias A. Hediger, Rajesh Bhardwaj
Publikováno v:
Augustynek, Bartlomiej; Gyimesi, Gergely; Dernič, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G; Peinelt, Christine; Hediger, Matthias A; Bhardwaj, Rajesh (2022). Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs. Cell calcium, 105, p. 102616. Elsevier 10.1016/j.ceca.2022.102616
In humans, there are three paralogs of the Orai Ca2+ channel that form the core of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still under active investigation, several artificial an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9272cd6a628f7d4b720cd36f1daa3c6b
https://doi.org/10.1016/j.ceca.2022.102616
https://doi.org/10.1016/j.ceca.2022.102616
Autor:
Rajesh Bhardwaj, Toshiyuki Tsunoda, Senji Shirasawa, Matthias A. Hediger, Inti Zlobec, Jonai Pujol Giménez, Damian T. Nydegger, Palanivel Kandasamy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2704371701749258c7eddeec5760f75b
https://doi.org/10.1002/1878-0261.12999/v2/response1
https://doi.org/10.1002/1878-0261.12999/v2/response1
Autor:
Rajesh, Bhardwaj, Bartłomiej S, Augustynek, Ebru, Ercan-Herbst, Palanivel, Kandasamy, Matthias, Seedorf, Christine, Peinelt, Matthias A, Hediger
Publikováno v:
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 54(2)
Store-operated CaThe CaHere we identified residues LeuTaken together, we propose a mechanistic model, wherein binding of Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b422777fd81e2c7736cd97ee66b37e13
https://pubmed.ncbi.nlm.nih.gov/32176842
https://pubmed.ncbi.nlm.nih.gov/32176842
Autor:
Manikandan Lakshmanan, Venkateshwaran Krishnaswami, Rajaguru Palanichamy, Abimanyu Sugumaran, Chandrasekar Ponnusamy, Subramanian Natesan, Palanivel Kandasamy, Ruckmani Kandasamy
Publikováno v:
European Journal of Pharmaceutical Sciences. 116:15-25
Targeted delivery of anticancer agents is poised to improve cancer therapy, for which polymers can serve as targeting ligands or nanocarriers for chemotherapeutic agents. In this study, we have developed and evaluated the efficacy of a camptothecin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaf6b440952a8aee2dcab96f329f4f3
https://doi.org/10.1016/j.ejps.2017.10.005
https://doi.org/10.1016/j.ejps.2017.10.005
Amino acid transporters (AATs) are membrane-bound transport proteins that mediate transfer of amino acids into and out of cells or cellular organelles. AATs have diverse functional roles ranging from neurotransmission to acid-base balance, intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1a9ed9293d5a6cf026e86ce4c478cc