Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Palak R. Parekh"'
Autor:
Palak R. Parekh, Eduardo Solano-Gonzalez, Mariana B. Martins, Xinrong Ma, Kayla Tighe, Andrea Casildo, Andrew Zodda, Christopher Johnstone, Yannick Poirier, Javed Mahmood, Kavita Bhalla, Sheri Li, Rena G. Lapidus, France Carrier
Publikováno v:
Cancers, Vol 13, Iss 16, p 4186 (2021)
Treatment options are rather limited for gastrointestinal cancer patients whose disease has disseminated into the intra-abdominal cavity. Here, we designed pre-clinical studies to evaluate the potential application of chemopotentiation by Low Dose Fr
Externí odkaz:
https://doaj.org/article/31eea971bed24792b9d5956ffcaa8976
Autor:
Urbain Weyemi, Christophe E. Redon, Rohini Choudhuri, Towqir Aziz, Daisuke Maeda, Myriem Boufraqech, Palak R. Parekh, Taresh K. Sethi, Manjula Kasoji, Natalie Abrams, Anand Merchant, Vinodh N. Rajapakse, William M. Bonner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The histone H2A variants are involved in DNA repair, gene regulation and cancer development. In this study, the authors unravel an additional role for H2A.X in the regulation of mesenchymal-like traits and activation of the EMT transcription factors,
Externí odkaz:
https://doaj.org/article/3167703fb83c4199980e307269ce14a0
Autor:
Palak R, Parekh, Gregory M, Botting, Denise B, Thurber, Marika, Boruszczak, William, Murphy, Greg P, Bertenshaw
Publikováno v:
Tumor Biology. 44:249-267
BACKGROUND: Non-small cell lung cancer (NSCLC) is a leading cause of cancer deaths. Current companion diagnostics use driver mutation sequencing to select patients for molecularly targeted agents (MTA), even though most patients lack actionable mutat
Autor:
Andrew Zodda, Sheri Li, Christopher Daniel Johnstone, Mariana B Martins, Xinrong Ma, Kayla M. Tighe, Kavita Bhalla, Eduardo Solano-Gonzalez, Andrea Casildo, Palak R Parekh, Javed Mahmood, Yannick Poirier, Rena G. Lapidus
Publikováno v:
Cancers
Volume 13
Issue 16
Cancers, Vol 13, Iss 4186, p 4186 (2021)
Volume 13
Issue 16
Cancers, Vol 13, Iss 4186, p 4186 (2021)
Treatment options are rather limited for gastrointestinal cancer patients whose disease has disseminated into the intra-abdominal cavity. Here, we designed pre-clinical studies to evaluate the potential application of chemopotentiation by Low Dose Fr
Autor:
Olga A. Martin, Christophe E. Redon, William M. Bonner, Urbain Weyemi, Rohini Choudhuri, Palak R. Parekh
Publikováno v:
Cancer Medicine
The development of novel cancer treatments is a challenging task, partly because results from model systems often fail to predict drug efficacy in humans, and also tumors are often inaccessible for biochemical analysis, preventing effective monitorin
Publikováno v:
Radiation Research. 184:151-160
Whole-abdominal radiotherapy (WART) is a primary method for managing gastrointestinal cancers that have disseminated into intra-abdominal tissues. While effective, this approach is limited because of the increased toxicity to normal tissue associated
Autor:
Michael Y. Bonner, Rohini Choudhuri, William M. Bonner, Christophe E. Redon, Palak R. Parekh, Urbain Weyemi, Jack L. Arbiser, Towqir Aziz, Daisuke Maeda
Publikováno v:
Proceedings of the National Academy of Sciences. 112:2121-2126
Ataxia telangiectasia (A-T), a rare autosomal recessive disorder characterized by progressive cerebellar degeneration and a greatly increased incidence of cancer among other symptoms, is caused by a defective or missing ataxia telangiectasia mutated
Autor:
Thomas B. Kryston, William M. Bonner, Alexandros G. Georgakilas, Nicholas F. Ferguson, Olga A. Martin, Jennifer S. Dickey, Christophe E. Redon, Palak R. Parekh, Asako J. Nakamura, James B. Mitchell
Publikováno v:
Cancer Letters. 353:248-257
Recently we found that mice bearing subcutaneous non-metastatic tumors exhibited elevated levels of two types of complex DNA damage, i.e., double-strand breaks and oxidatively-induced clustered DNA lesions in various tissues throughout the body, both
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:502-514
Reactive oxygen species (ROS) form a class of molecules with both positive and negative impacts on cellular health. Negatively, ROS may react with cellular constituents including proteins, lipids, and DNA to generate an array of oxidative lesions. Th
Autor:
Taresh K. Sethi, Natalie Abrams, Vinodh N. Rajapakse, Christophe E. Redon, William M. Bonner, Anand S. Merchant, Towqir Aziz, Manjula Kasoji, Palak R. Parekh, Rohini Choudhuri, Urbain Weyemi, Myriem Boufraqech, Daisuke Maeda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
The epithelial–mesenchymal transition (EMT), considered essential for metastatic cancer, has been a focus of much research, but important questions remain. Here, we show that silencing or removing H2A.X, a histone H2A variant involved in cellular D