Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Palak R. Parekh"'
Autor:
Urbain Weyemi, Christophe E. Redon, Rohini Choudhuri, Towqir Aziz, Daisuke Maeda, Myriem Boufraqech, Palak R. Parekh, Taresh K. Sethi, Manjula Kasoji, Natalie Abrams, Anand Merchant, Vinodh N. Rajapakse, William M. Bonner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The histone H2A variants are involved in DNA repair, gene regulation and cancer development. In this study, the authors unravel an additional role for H2A.X in the regulation of mesenchymal-like traits and activation of the EMT transcription factors,
Externí odkaz:
https://doaj.org/article/3167703fb83c4199980e307269ce14a0
Autor:
Palak R, Parekh, Gregory M, Botting, Denise B, Thurber, Marika, Boruszczak, William, Murphy, Greg P, Bertenshaw
Publikováno v:
Tumor Biology. 44:249-267
BACKGROUND: Non-small cell lung cancer (NSCLC) is a leading cause of cancer deaths. Current companion diagnostics use driver mutation sequencing to select patients for molecularly targeted agents (MTA), even though most patients lack actionable mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d8af68c5047e7472d7bab23149166f
https://doi.org/10.3233/tub-220009
https://doi.org/10.3233/tub-220009
Autor:
Andrew Zodda, Sheri Li, Christopher Daniel Johnstone, Mariana B Martins, Xinrong Ma, Kayla M. Tighe, Kavita Bhalla, Eduardo Solano-Gonzalez, Andrea Casildo, Palak R Parekh, Javed Mahmood, Yannick Poirier, Rena G. Lapidus
Publikováno v:
Cancers
Volume 13
Issue 16
Cancers, Vol 13, Iss 4186, p 4186 (2021)
Volume 13
Issue 16
Cancers, Vol 13, Iss 4186, p 4186 (2021)
Treatment options are rather limited for gastrointestinal cancer patients whose disease has disseminated into the intra-abdominal cavity. Here, we designed pre-clinical studies to evaluate the potential application of chemopotentiation by Low Dose Fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe9a501d1edb87e9712190fb02e69d6
Autor:
Olga A. Martin, Christophe E. Redon, William M. Bonner, Urbain Weyemi, Rohini Choudhuri, Palak R. Parekh
Publikováno v:
Cancer Medicine
The development of novel cancer treatments is a challenging task, partly because results from model systems often fail to predict drug efficacy in humans, and also tumors are often inaccessible for biochemical analysis, preventing effective monitorin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f965dd3d50d13d674efdb6be084adda
https://doi.org/10.1002/cam4.726
https://doi.org/10.1002/cam4.726
Publikováno v:
Radiation Research. 184:151-160
Whole-abdominal radiotherapy (WART) is a primary method for managing gastrointestinal cancers that have disseminated into intra-abdominal tissues. While effective, this approach is limited because of the increased toxicity to normal tissue associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bd0b3b23c6e813239332536132f8f4
https://doi.org/10.1667/rr13661.1
https://doi.org/10.1667/rr13661.1
Autor:
Thomas B. Kryston, William M. Bonner, Alexandros G. Georgakilas, Nicholas F. Ferguson, Olga A. Martin, Jennifer S. Dickey, Christophe E. Redon, Palak R. Parekh, Asako J. Nakamura, James B. Mitchell
Publikováno v:
Cancer Letters. 353:248-257
Recently we found that mice bearing subcutaneous non-metastatic tumors exhibited elevated levels of two types of complex DNA damage, i.e., double-strand breaks and oxidatively-induced clustered DNA lesions in various tissues throughout the body, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b51b991d591358075350a02134e23a
https://doi.org/10.1016/j.canlet.2014.07.030
https://doi.org/10.1016/j.canlet.2014.07.030
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:502-514
Reactive oxygen species (ROS) form a class of molecules with both positive and negative impacts on cellular health. Negatively, ROS may react with cellular constituents including proteins, lipids, and DNA to generate an array of oxidative lesions. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267224f6aad0b4a7b269d0bd57b516af
https://doi.org/10.2174/1871520611313030013
https://doi.org/10.2174/1871520611313030013
Autor:
Brandon J. Baird, Christophe E. Redon, Asako J. Nakamura, William M. Bonner, Yuri Griko, Olga A. Martin, Alexandros G. Georgakilas, Palak R. Parekh, Jennifer S. Dickey, Khaled Aziz
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 711:142-149
Hibernation is an established strategy used by some homeothermic organisms to survive cold environments. In true hibernation, the core body temperature of an animal may drop to below 0 °C and metabolic activity almost cease. The phenomenon of hibern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4298fc075cc5834d0225cf48496a82df
https://doi.org/10.1016/j.mrfmmm.2010.12.006
https://doi.org/10.1016/j.mrfmmm.2010.12.006
Publikováno v:
Experimental and Toxicologic Pathology. 63:167-173
Resveratrol is a naturally occurring phytoalexin with antioxidant activity. The chemopreventive effects of resveratrol against various types of cancer are well known, though the underlying molecular mechanisms of its action are still not identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288884152d53f004a3df7cbf2fd7a73a
https://doi.org/10.1016/j.etp.2009.11.005
https://doi.org/10.1016/j.etp.2009.11.005
Publikováno v:
Cancer Research. 78:4434-4434
Prostate cancer is the third leading cause of cancer deaths among men in the United States, with recurrent metastasis being the predominant cause of mortality. In spite of the significant progress made in the past half century with hormonal therapy f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7b314f1a017dc9177cad223f209c723
https://doi.org/10.1158/1538-7445.am2018-4434
https://doi.org/10.1158/1538-7445.am2018-4434