Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Pal, Pacher"'
Autor:
Cassandra E. Bradley, Emma Fletcher, Trevor Wilkinson, Andrew Ring, Lucas Cardona Ferrer, Dimitrios Miserlis, Pal Pacher, Panagiotis Koutakis
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 523-533 (2024)
Peripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading to reduced blood flow and oxygen supp
Externí odkaz:
https://doaj.org/article/8f606c8942c544229b58f02dd5a81979
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Taha Kelestemur, Zoltán H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig, György Haskó
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of adenosine 5’ triphosp
Externí odkaz:
https://doaj.org/article/4238d3f9218f4b0c981e481ab1ebd3be
Autor:
Xiaoting Li, Hao Chang, Jara Bouma, Laura V. de Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J. B. H. N. van den Berg, Antonius P. A. Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H. Heitman, Tian Hua
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. Here, authors report the discovery of LEI-102, a CB2R agonist, used in conjunction with three other CBR ligands (APD371, HU308, and CP55,940) to investigat
Externí odkaz:
https://doaj.org/article/4a0327fb90ed454caed0f1b796b69018
Autor:
Reem Smoum, Uwe Grether, Meliha Karsak, Andrea J. Vernall, Frank Park, Cecilia J. Hillard, Pal Pacher
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/91648edd20fd4d4880fc5daf2c89b600
Autor:
Shaogui Wang, Hong-Min Ni, Xiaojuan Chao, Xiaowen Ma, Thomas Kolodecik, Robert De Lisle, Andrew Ballabio, Pal Pacher, Wen-Xing Ding
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 59-81 (2020)
Background & Aims: Alcohol abuse is the major cause of experimental and human pancreatitis but the molecular mechanisms remain largely unknown. We investigated the role of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in
Externí odkaz:
https://doaj.org/article/7c062c72fdbf45cc99a47741f74c977f
Autor:
Janos Paloczi, PhD, Csaba Matyas, MD, PhD, Resat Cinar, PhD, Zoltan V. Varga, MD, PhD, György Hasko, MD, PhD, Thomas H. Schindler, MD, George Kunos, MD, PhD, Pal Pacher, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 5, Pp 625-637 (2019)
Summary: Excessive binge alcohol drinking may adversely affect cardiovascular function. In this study we characterize the detailed hemodynamic effects of an acute alcohol binge in mice using multiple approaches and investigate the role of the endocan
Externí odkaz:
https://doaj.org/article/a577b1cc3f614595aa2a64840c10c88f
Autor:
Zhou Zhou, Ming-Jiang Xu, Yan Cai, Wei Wang, Joy X. Jiang, Zoltan V. Varga, Dechun Feng, Pal Pacher, George Kunos, Natalie J. Torok, Bin Gao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 399-413 (2018)
Hepatic infiltration of neutrophils is a hallmark of steatohepatitis; however, the role of neutrophils in the progression of steatohepatitis remains unknown. Methods: A clinically relevant mouse model of steatohepatitis induced by high-fat diet (HFD)
Externí odkaz:
https://doaj.org/article/ce77d5a5e14049ddaa2dd7c3b140f004
Autor:
Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, Travis W. Grim, Filomena Fezza, Luciano de Petrocellis, Christoph Ullmer, Benno Rothenhäusler, Camille Perret, Noortje van Gils, David Finlay, Christa MacDonald, Andrea Chicca, Marianela Dalghi Gens, Jordyn Stuart, Henk de Vries, Nicolina Mastrangelo, Lizi Xia, Georgios Alachouzos, Marc P. Baggelaar, Andrea Martella, Elliot D. Mock, Hui Deng, Laura H. Heitman, Mark Connor, Vincenzo Di Marzo, Jürg Gertsch, Aron H. Lichtman, Mauro Maccarrone, Pal Pacher, Michelle Glass, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitab
Externí odkaz:
https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e6
Autor:
Shani Abraham, Chad Lindo, Jessica Peoples, Amanda Cox, Erika Lytle, Vu Nguyen, Meeti Mehta, Jose D. Alvarez, Shibu Yooseph, Pal Pacher, Steven N. Ebert
Publikováno v:
Alcoholism: Clinical and Experimental Research. 46:1433-1448
Excessive alcohol consumption during pregnancy is associated with high risk of congenital heart defects, but it is unclear how alcohol specifically affects heart development during the acute aftermath of a maternal binge drinking episode. We hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a615d747413c41e20cdac592b3ed0ae
https://doi.org/10.1111/acer.14880
https://doi.org/10.1111/acer.14880