Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Pal'keeva ME"'
Autor:
Maria Sidorova, Alexander A. Timoshin, Irina Studneva, M. V. Ovchinnikov, L. I. Serebryakova, A. S. Molokoedov, A. A. Az’muko, Oksana Veselova, Oleg I. Pisarenko, Pal'keeva Me
Publikováno v:
International Journal of Peptide Research and Therapeutics. 27:2039-2048
Natural and chemically modified N-terminal galanin fragments (WTLNSAGYLLGPHA-OH (G1) and WTLNSAGYLLGPβAH-OH (G2), respectively) reduce functional and metabolic disturbances in the heart during experimental ischemia and reperfusion. The aim of this w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54baa3a53f72d40e2957f44278c1f1fb
https://doi.org/10.1007/s10989-021-10231-x
https://doi.org/10.1007/s10989-021-10231-x
Autor:
A. A. Az’muko, A. S. Molokoedov, Maria Sidorova, M. V. Ovchinnikov, U S Dudkina, E. V. Kudryavtseva, D. V. Avdeev, Pal'keeva Me, Tatiana I. Arefieva, V. N. Bushuev, S. B. Grechishnikov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:520-529
The solid phase synthesis (SPS) of the ingramon peptide antagonist of the human monocyte chemoattractant protein-1 (H-Asp-His-Leu-Asp-Lys-Gln-Thr-Gln-Thr-Pro-Lys-Thr-OH), which exhibited the anti-inflammatory activity, was optimized. Side products of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e0f7a7922d481cbaf9abac3f979548
https://doi.org/10.1134/s1068162020040202
https://doi.org/10.1134/s1068162020040202
Autor:
A. S. Molokoedov, Pal'keeva Me, A. A. Az’muko, D. V. Avdeev, L. I. Serebryakova, M. V. Ovchinnikov, Oleg I. Pisarenko, Irina Studneva, O M Veselova, Maria Sidorova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:32-42
The full-length rat galanin (GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-NH2, G29) was prepared by the solid phase peptide synthesis using the Fmoc-strategy. The peptide chain was elongated both by one amino acid and by a fragment condensation. Fragments with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fae14ee36c7ea67c8fd87906f43f0439
https://doi.org/10.1134/s1068162020010100
https://doi.org/10.1134/s1068162020010100
Autor:
Aydar A. Ishmukhametov, R. Sh. Bibilashvili, Sidorova Mv, Pal'keeva Me, Liubov I. Kozlovskaya, U S Dudkina, A S Molokoedov, Alexey M. Egorov, Ye V Parfyonova
Publikováno v:
Biomeditsinskaia khimiia. 67(3)
Computer simulation has been used to identify peptides that mimic the natural target of the SARS-CoV-2 coronavirus spike (S) protein, the angiotensin converting enzyme type 2 (ACE2) cell receptor. Based on the structure of the complex of the protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fd53587242f32e33336619cdfda65f
https://pubmed.ncbi.nlm.nih.gov/34142531
https://pubmed.ncbi.nlm.nih.gov/34142531
Autor:
A. S. Molokoedov, Pal'keeva Me, A. A. Az’muko, L. I. Serebryakova, Irina Studneva, M. V. Ovchinnikov, O M Veselova, Oleg I. Pisarenko, Maria Sidorova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:353-360
New peptide analogs of galanin corresponding to fragments of the N-terminal sequence were synthesized by an automatic solid-phase method using Fmoc-technology. Incomplete cleavage of the Boc-protection from the Trp indole ring was found during postsy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02c8db5bd3c34d4260e91e0229482756
https://doi.org/10.1134/s1068162019040071
https://doi.org/10.1134/s1068162019040071
Autor:
Irina Studneva, O M Veselova, Oleg I. Pisarenko, A. S. Molokoedov, M. V. Ovchinnikov, Maria Sidorova, Pal'keeva Me, R O Lubimov
Publikováno v:
Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 13:167-172
The clinical application of the anticancer agent doxorubicin (Dox) is limited due to its cardiotoxic effect. Using the method of automated solid-phase peptide synthesis, we obtained a synthetic agonist of galanin receptors GalR1-3 [βAla14, His15]-ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff1b2d27c2889c4c7bd280f10fe067e
https://doi.org/10.1134/s1990750819020100
https://doi.org/10.1134/s1990750819020100
Autor:
Pal'keeva Me, M. V. Ovchinnikov, Irina Studneva, Maria Sidorova, O M Veselova, R O Lubimov, A. S. Molokoedov, Oleg I. Pisarenko
Publikováno v:
Biomeditsinskaya Khimiya. 65:51-56
The use of the anticancer drug doxorubicin (Dox) is limited due to its cardiotoxic effect. Using the method of automatic solid-phase peptide synthesis, we obtained a synthetic agonist of galanin receptors GalR1-3 [RAla14, His15]-galanine (2-15) (G),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae32483699fc3f73ee4093c3a1c2d37
https://doi.org/10.18097/pbmc20196501051
https://doi.org/10.18097/pbmc20196501051
Autor:
Oleg I. Pisarenko, Maria Sidorova, Oksana Veselova, Irina Studneva, A. S. Molokoedov, Pal'keeva Me, L. I. Serebryakova, M. V. Ovchinnikov, Radik Gataulin
Publikováno v:
Peptides. 111:127-131
Agonists and antagonists for galanin receptor subtypes GalR1-3 can be used as putative therapeutics targets for the treatment of various human diseases. However, effects of galanin and its N-terminal fragments on myocardial ischemia/reperfusion injur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e2f581860c81b32645b3754c018b00
https://doi.org/10.1016/j.peptides.2018.05.001
https://doi.org/10.1016/j.peptides.2018.05.001
Autor:
M. V. Ovchinnikov, L. I. Serebryakova, A. S. Molokoedov, Pal'keeva Me, Oleg I. Pisarenko, Irina Studneva, Oksana Veselova, Maria Sidorova
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 109, Iss, Pp 1556-1562 (2019)
N-terminal fragments of galanin (2–11) and (2–15) are critical for binding to GalR1-3 receptors, members of the G-protein-coupled receptor superfamily, and are involved in myocardial protection against ischemia/reperfusion (I/R) injury. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c099d8abec6e33759a0adafea5a62d
https://doi.org/10.1016/j.biopha.2018.09.182
https://doi.org/10.1016/j.biopha.2018.09.182
Autor:
A. A. Az’muko, M. V. Ovchinnikov, A. S. Molokoedov, Oleg I. Pisarenko, V. N. Bushuev, Pal'keeva Me, Maria Sidorova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:18-26
A method for the solid-phase synthesis of the apelin-12 analog has been developed using the Fmoc methodology in combination with the temporary protection of the guanidine function of the arginine residues by protonation (salt formation) during the fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a227add436ffc1ef03969a6008972598
https://doi.org/10.1134/s106816201901014x
https://doi.org/10.1134/s106816201901014x