Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Pakorn Kanchanawong"'
Autor:
Nicole Morales-Camilo, Jingzhun Liu, Manuel J. Ramírez, Patricio Canales-Salgado, Juan José Alegría, Xuyao Liu, Hui Ting Ong, Nelson P. Barrera, Angélica Fierro, Yusuke Toyama, Benjamin T. Goult, Yilin Wang, Yue Meng, Ryosuke Nishimura, Kedsarin Fong-Ngern, Christine Siok Lan Low, Pakorn Kanchanawong, Jie Yan, Andrea Ravasio, Cristina Bertocchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Force transmission through adherens junctions (AJs) is crucial for multicellular organization, wound healing and tissue regeneration. Recent studies shed light on the molecular mechanisms of mechanotransduction at the AJs. However, the canon
Externí odkaz:
https://doaj.org/article/6be83a197f51435ca5f41022c5884809
Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Autor:
Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F. H. Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D. Bershadsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
In this work, the authors identify regulators of actin filament assembly involved in chiral organisation of the actin cytoskeleton in single cells and chiral alignment of cells in groups. This provides insights into how actin-driven chirality underli
Externí odkaz:
https://doaj.org/article/a04bac554ea94ed8891bb4b8355d7cab
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Cell morphology is profoundly influenced by cellular interactions with microenvironmental factors such as the extracellular matrix (ECM). Upon adhesion to specific ECM, various cell types are known to exhibit different but distinctive morpho
Externí odkaz:
https://doaj.org/article/be3f1632b38d4b9d8e2a1cbb9b3feefe
Autor:
Darren Chen Pei Wong, Jingwei Xiao, Ti Weng Chew, Meng Pan, Chang Jie Mick Lee, Jing Wen Ang, Ivan Yow, T. Thivakar, Matthew Ackers‐Johnson, Nicole Jia Wen Lee, Roger Sik‐Yin Foo, Pakorn Kanchanawong, Boon Chuan Low
Publikováno v:
Advanced Science, Vol 9, Iss 31, Pp n/a-n/a (2022)
Abstract Rho GTPases and Hippo kinases are key regulators of cardiomyoblast differentiation. However, how these signaling axes are coordinated spatiotemporally remains unclear. Here, the central and multifaceted roles of the BCH domain containing pro
Externí odkaz:
https://doaj.org/article/2acb50b798ec4d8d8b2d1efc6f819dad
Autor:
Michelle Joy-Immediato, Manuel J. Ramirez, Mauricio Cerda, Yusuke Toyama, Andrea Ravasio, Pakorn Kanchanawong, Cristina Bertocchi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. While the role of the actin cytoskeleton in withstanding tension at these sites of contact is well documented, little is
Externí odkaz:
https://doaj.org/article/14d80485e05843fc987613d9bc4f0494
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background The stress fibers are prominent organization of actin filaments that perform important functions in cellular processes such as migration, polarization, and traction force generation, and whose collective organization reflects the
Externí odkaz:
https://doaj.org/article/533227d966bf4880b471cd674805420c
Autor:
Shumin Xia, Ying Bena Lim, Zhen Zhang, Yilin Wang, Shan Zhang, Chwee Teck Lim, Evelyn K.F. Yim, Pakorn Kanchanawong
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1251-1267.e7 (2019)
Summary: Mechanical cues influence pluripotent stem cell differentiation, but the underlying mechanisms are not well understood. Mouse embryonic stem cells (mESCs) exhibit unusual cytomechanical properties, including low cell stiffness and attenuated
Externí odkaz:
https://doaj.org/article/c491c3602104492690fce6764adf3667
Autor:
Miao Yu, Shimin Le, Samuel Barnett, Zhenhuan Guo, Xueying Zhong, Pakorn Kanchanawong, Jie Yan
Publikováno v:
Physical Review X, Vol 10, Iss 2, p 021001 (2020)
Molecular optogenetic switch systems are extensively employed as a powerful tool to spatially and temporally modulate a variety of signal transduction processes in cells. However, the applications of such systems in mechanotransduction processes wher
Externí odkaz:
https://doaj.org/article/0029205f72ef4d36b3a87106946820d9
Autor:
Satoko Sakamoto, Dean Thumkeo, Hiroshi Ohta, Zhen Zhang, Shuangru Huang, Pakorn Kanchanawong, Takayoshi Fuu, Sadanori Watanabe, Kentaro Shimada, Yoshitaka Fujihara, Shosei Yoshida, Masahito Ikawa, Naoki Watanabe, Mitinori Saitou, Shuh Narumiya
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2004874 (2018)
Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture of
Externí odkaz:
https://doaj.org/article/d970502460524e6db266d670942d5be9
Autor:
Chwee Tat Koe, Ye Sing Tan, Max Lönnfors, Seong Kwon Hur, Christine Siok Lan Low, Yingjie Zhang, Pakorn Kanchanawong, Vytas A Bankaitis, Hongyan Wang
Publikováno v:
eLife, Vol 7 (2018)
A central feature of most stem cells is the ability to self-renew and undergo differentiation via asymmetric division. However, during asymmetric division the role of phosphatidylinositol (PI) lipids and their regulators is not well established. Here
Externí odkaz:
https://doaj.org/article/f89c1270291546408dfdbcb38f7cbefd