Výsledky vyhledávání - "Pak-Kei Chan"

Akademický článek

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

Autor: Dharmendra Dingar, William B. Tu, Diana Resetca, Corey Lourenco, Aaliya Tamachi, Jason De Melo, Kathleen E. Houlahan, Manpreet Kalkat, Pak-Kei Chan, Paul C. Boutros, Brian Raught, Linda Z. Penn

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here the authors find that protein phosphatase 1 and its regulatory subunit PNUTS controls MYC stability and its interaction with chromatin.

Externí odkaz: https://doaj.org/article/cc8066c5d0d249efbc4b69b3a8efd7c8

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Akademický článek

BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors

Autor: Pak-Kei Chan, Tharan Srikumar, Dharmendra Dingar, Manpreet Kalkat, Linda Z. Penn, Brian Raught

Publikováno v: Data in Brief, Vol 1, Iss C, Pp 76-78 (2014)

BioID was performed using FlagBirA⁎ (the R118G biotin ligase mutant protein) and FlagBirA⁎-Myc in HEK293 T-REx cells maintained both under standard cell culture conditions and as mouse xenografts. The mass spectrometry dataset acquired in this st

Externí odkaz: https://doaj.org/article/3ee5430f45cf41c8b7fe0315e0de2dd3

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Akademický článek

Identification of c-MYC SUMOylation by mass spectrometry.

Autor: Manpreet Kalkat, Pak-Kei Chan, Amanda R Wasylishen, Tharan Srikumar, Sam S Kim, Romina Ponzielli, David P Bazett-Jones, Brian Raught, Linda Z Penn

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115337 (2014)

The c-MYC transcription factor is a master regulator of many cellular processes and deregulation of this oncogene has been linked to more than 50% of all cancers. This deregulation can take many forms, including altered post-translational regulation.

Externí odkaz: https://doaj.org/article/36543a850d5a4a229521ec2c61e6d4e2

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