Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Pak-Hin Hinson Cheung"'
Autor:
Chon Phin Ong, Kaiming Tang, Pak-Hin Hinson Cheung, Hongzhuo Zhang, Tze-Tung Tang, Yaqian Xue, Junjue Wang, Kelvin Kai-Wang To, Shuofeng Yuan, Zi-Wei Ye, Dong-Yan Jin
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-5 (2023)
Abstract We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effecti
Externí odkaz:
https://doaj.org/article/e460d8cd22ca4a1b98a50cc044fc51a8
Autor:
Wai-Yin Lui, Chon Phin Ong, Pak-Hin Hinson Cheung, Zi-Wei Ye, Chi-Ping Chan, Kelvin Kai-Wang To, Kit-San Yuen, Dong-Yan Jin
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTSARS-CoV-2, the causative agent of COVID-19, has been intensely studied in search of effective antiviral treatments. The immunosuppressant cyclosporine A (CsA) has been suggested to be a pan-coronavirus inhibitor, yet its underlying mechanism
Externí odkaz:
https://doaj.org/article/e71fe5a1eb514d30af75e326098c46a3
Autor:
Yun Cheng, Xiao-Zhuo Kang, Pearl Chan, Pak-Hin Hinson Cheung, Tao Cheng, Zi-wei Ye, Chi-Ping Chan, Cheng-Han Yu, Dong-Yan Jin
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Background Cholesterol plays a vital role in multiple physiological processes. Cellular uptake of cholesterol is mediated primarily through endocytosis of low-density lipoprotein (LDL) receptor. New modifiers of this process remain to be cha
Externí odkaz:
https://doaj.org/article/151620cd7ddc47e79eb1d9848509abc0
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1072-1078 (2022)
Externí odkaz:
https://doaj.org/article/8372ec38d54e4cf388da375bf49a2aed
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract In February 2020, we highlighted the top nine important research questions on SARS-CoV-2 and COVID-19 concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus a
Externí odkaz:
https://doaj.org/article/788a51cc7f3c446da1f20d87650dfcbf
Autor:
Pak-Hin Hinson Cheung, Tak-Wang Terence Lee, Chun Kew, Honglin Chen, Kwok-Yung Yuen, Chi-Ping Chan, Dong-Yan Jin
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008611 (2020)
Human infection with avian influenza A (H5N1) and (H7N9) viruses causes severe respiratory diseases. PB1-F2 protein is a critical virulence factor that suppresses early type I interferon response, but the mechanism of its action in relation to high p
Externí odkaz:
https://doaj.org/article/fccd3d1047644b83b2956f4ec4916173
Autor:
Pak‐Hin Hinson Cheung, Zi‐Wei Ye, Wai‐Yin Lui, Chon Phin Ong, Pearl Chan, Tak‐Wang Terence Lee, Tze‐Tung Tang, Tin‐Long Yuen, Sin‐Yee Fung, Yun Cheng, Ching‐Ping Chan, Chi‐Ping Chan, Dong‐Yan Jin
Publikováno v:
Journal of Medical Virology. 94:6078-6090
Single-cycle infectious virus can elicit close-to-natural immune response and memory. One approach to generate single-cycle severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is through deletion of structural genes such as spike (S) and nuc
Autor:
Zi-Wei Ye, Yilan Fan, Kaiming Tang, Chon Phin Ong, Cuiting Luo, Hon-Lam Chung, Tsun-Lam Leong, Ronghui Liang, Wai-Yin Lui, Runhong Zhou, Yun Cheng, Lu Lu, Pak-Hin Hinson Cheung, Jasper Fuk-Woo Chan, Zhiwei Chen, Kwok-Yung Yuen, Shuofeng Yuan, Kelvin Kai-Wang To, Dong-Yan Jin
Publikováno v:
International journal of biological sciences. 18(12)
Rapid development and successful use of vaccines against SARS-CoV-2 might hold the key to curb the ongoing pandemic of COVID-19. Emergence of vaccine-evasive SARS-CoV-2 variants of concern (VOCs) has posed a new challenge to vaccine design and develo
Autor:
Pak-Hin Hinson Cheung, Chi-Ping Chan, Zi-Wei Ye, Tak-Wang Terence Lee, Honglin Chen, Dong-Yan Jin
Publikováno v:
Journal of Leukocyte Biology. 108:1655-1663
Infection with seasonal as well as highly pathogenic avian influenza A virus (IAV) causes significant morbidity and mortality worldwide. As a major virulence factor, PB1-F2 protein of IAV affects the severity of disease through multiple mechanisms in
Publikováno v:
Journal of Leukocyte Biology. 107:763-771
Influenza A virus (IAV) causes not only seasonal respiratory illness, but also outbreaks of more severe disease and pandemics when novel strains emerge as a result of reassortment or interspecies transmission. PB1-F2 is an IAV protein expressed from