Zobrazeno 1 - 10
of 372
pro vyhledávání: '"Pak H Chan"'
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 2, Pp 229-239 (2004)
Oxidative damage to the endoplasmic reticulum (ER) could be involved in ischemic neuronal cell death because this organelle is susceptible to reactive oxygen species. Using wild-type mice and copper/zinc-superoxide dismutase (SOD1) transgenic mice, w
Externí odkaz:
https://doaj.org/article/45d74c1ea5874790a377b1c13a9530b0
Autor:
Yu-Yo Sun, Yury M Morozov, Dianer Yang, Yikun Li, R Scott Dunn, Pasko Rakic, Pak H Chan, Koji Abe, Diana M Lindquist, Chia-Yi Kuan
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98807 (2014)
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-eda
Externí odkaz:
https://doaj.org/article/46b6060a8b7243149c112cf5d943802f
Autor:
Pak H. Chan
Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investig
Autor:
Pak H. Chan
Publikováno v:
Cellular Antioxidant Defense Mechanisms ISBN: 9780429289323
Cellular Antioxidant Defense Mechanisms
Cellular Antioxidant Defense Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48acdf61c3e5ca5eec5c54f67578fe9
https://doi.org/10.1201/9780429289323-4
https://doi.org/10.1201/9780429289323-4
Autor:
Hideyuki Yoshioka, Hiroyuki Sakata, Purnima Narasimhan, Pak H. Chan, Hiroyuki Kinouchi, Takuma Wakai
Publikováno v:
Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism). 26:239-244
Previous studies have shown that intraparenchymal transplantation of neural stem cells (NSCs) ameliorates neurologic deficits in animals with intracerebral hemorrhage (ICH). However, massive grafted cell death after transplantation, possibly caused b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5144c410361b54c90741d633b106e6f6
https://doi.org/10.16977/cbfm.26.2_239
https://doi.org/10.16977/cbfm.26.2_239
Autor:
Sharareh Gholamin, Varsha Rao, Jenny Yuan, Amanda T. Mah, Howard Y. Chang, Mario Vallon, Samuel H. Cheshier, Carolina M. Maier, Ari D Brettman, Jeffrey W. Kwong, Pak H. Chan, Xibin Liang, Katrin I. Andreasson, Frank Kuhnert, David C Corney, Lu Yang, Cynthia Kosinski, Kanako Yuki, Shin Heng Chiou, Lauren Daly, L Li, Lijun Xu, Michael R. Mancuso, Calvin J. Kuo, Michael Snyder, Xiaoyuan Han, Teresa F Reyes, Rui Li, Jing Wang, Rona G. Giffard, J J Haijing Zhang, Linda D. Shortliffe, Junlei Chang, Xiwei Wu
Although blood-brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. The endothelial G-protein-coupled receptor (GPCR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41904df2924fe0740cea05a3be55d628
https://europepmc.org/articles/PMC5559385/
https://europepmc.org/articles/PMC5559385/
Publikováno v:
Journal of Neuroscience Research. 93:140-148
Postconditioning mitigates ischemia-induced cellular damage via a modified reperfusion procedure. Mitochondrial permeability transition (MPT) is an important pathophysiological change in reperfusion injury. This study explores the role of MPT modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a827f1e83e5071e5ec9f01426cfe71c
https://doi.org/10.1002/jnr.23460
https://doi.org/10.1002/jnr.23460
Crush, Culotte, T and Protrusion: Which 2-Stent Technique for Treatment of True Bifurcation Lesions?
Autor:
Carlo Di Mario, Nicolas Foin, Justin E. Davies, Nicola Viceconte, Pak H. Chan, Eduardo Alegría-Barrero, Ryo Torii
Publikováno v:
Circulation Journal. 77:73-80
Background: Percutaneous coronary intervention of complex true bifurcation lesions often fails to ensure continuous stent coverage and strut apposition in both the side branch and main vessel. Struts left unopposed floating in the lumen disturb blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c292fd49be4de4c8b0a799a1b5153d99
https://doi.org/10.1253/circj.cj-12-0272
https://doi.org/10.1253/circj.cj-12-0272
Publikováno v:
Journal of Neurochemistry. 124:523-535
Oxidative stress after stroke is associated with the inflammatory system activation in the brain. The complement cascade, especially the degradation products of complement component 3, is a key inflammatory mediator of cerebral ischemia. We have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9348863fb780c0ce063cf66c2a8ae6
https://doi.org/10.1111/jnc.12111
https://doi.org/10.1111/jnc.12111
Autor:
Takuma Wakai, Purnima Narasimhan, Kuniyasu Niizuma, Pak H. Chan, Carolina M. Maier, Hiroyuki Sakata
Publikováno v:
Brain. 135:3298-3310
Transplantation of neural stem cells provides a promising therapy for stroke. Its efficacy, however, might be limited because of massive grafted-cell death after transplantation, and its insufficient capability for tissue repair. Interleukin 6 is a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeccbf41814db6a273e290996d7c631c
https://doi.org/10.1093/brain/aws259
https://doi.org/10.1093/brain/aws259