Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity

Autor: David J. Webb, Dinesh Talwar, Neeraj Dhaun, Jennifer S. Pollock, Vanessa Melville, Pajaree Lilitkarntakul, Barbara Liebman, Takae Asai, Jane Goddard, Scott Blackwell

Publikováno v: Atherosclerosis. 216:217-225

Patients with chronic kidney disease (CKD) have increased risk of cardiovascular disease to which co-morbidity and associated conventional risk factors contribute. We hypothesised that arterial stiffness (AS) and endothelial dysfunction (ED), as surr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4476373ede354dbe9e988d173b8d48
https://doi.org/10.1016/j.atherosclerosis.2011.01.045

Are rare diseases still orphans or happily adopted? The challenges of developing and using orphan medicinal products

Autor: David J. Webb, Pajaree Lilitkarntakul, James W. Dear

Publikováno v: Dear, J W, Lilitkarntakul, P & Webb, D J 2006, ' Are rare diseases still orphans or happily adopted? The challenges of developing and using orphan medicinal products ', British Journal of Clinical Pharmacology, vol. 62, no. 3, pp. 264-71 . https://doi.org/10.1111/j.1365-2125.2006.02654.x

Orphan medicinal products (OMPs) are targeted at the diagnosis, prevention or treatment of rare diseases and have a special status in European law. This status brings incentives for pharmaceutical companies to invest in OMP development. The goal of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645dbdd5614dd407b4868f4e15a477b5
https://doi.org/10.1111/j.1365-2125.2006.02654.x

Renal dysfunction does not affect the peripheral-to-central arterial pressure transfer function

Autor: Rupert Payne, Pajaree Lilitkarntakul, Vanessa Melville, David J. Webb, Takae Asai, Neeraj Dhaun, Jane Goddard

Publikováno v: Hypertension (Dallas, Tex. : 1979). 56(6)

Arterial generalized transfer functions (GTFs) are increasingly used to estimate central pressure from peripheral measurements. Analysis of derived central waveforms may be valuable in the assessment of patients with chronic kidney disease. The aim o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b246b87b2618fbea573d616027119e
https://pubmed.ncbi.nlm.nih.gov/21059999

Urinary endothelin-1 in chronic kidney disease and as a marker of disease activity in lupus nephritis

Autor: Neeraj Dhaun, David J. Webb, Eline W. Muilwijk, Jane Goddard, Neil R. Johnston, David C. Kluth, Pajaree Lilitkarntakul, Iain M. MacIntyre

Publikováno v: American Journal of Physiology : Renal Physiology, 296, 6, pp. F1477-83
American Journal of Physiology : Renal Physiology, 296, F1477-83

Item does not contain fulltext Chronic inflammation contributes to the development and progression of chronic kidney disease (CKD). Identifying renal inflammation early is important. There are currently no specific markers of renal inflammation. Endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0ca9b40ae0e6de0def40f9810f397d
https://europepmc.org/articles/PMC2692450/