Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paivi Saavalainen"'
Autor:
Manuel A Rivas, Brandon E Avila, Jukka Koskela, Hailiang Huang, Christine Stevens, Matti Pirinen, Talin Haritunians, Benjamin M Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Monkol Lek, Konrad J Karczewski, Jonathan Bloom, Eric V Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Aarno Palotie, Steven R Brant, Richard H Duerr, Mark S Silverberg, John D Rioux, Rinse K Weersma, Andre Franke, Luke Jostins, Carl A Anderson, Jeffrey C Barrett, Daniel G MacArthur, Chaim Jalas, Harry Sokol, Ramnik J Xavier, Ann Pulver, Judy H Cho, Dermot P B McGovern, Mark J Daly
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008190 (2019)
[This corrects the article DOI: 10.1371/journal.pgen.1007329.].
Externí odkaz:
https://doaj.org/article/3ae352ebf0834370b7f64609330444d8
Autor:
Manuel A Rivas, Brandon E Avila, Jukka Koskela, Hailiang Huang, Christine Stevens, Matti Pirinen, Talin Haritunians, Benjamin M Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Monkol Lek, Konrad J Karczewski, Jonathan Bloom, Eric V Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Aarno Palotie, Steven R Brant, Richard H Duerr, Mark S Silverberg, John D Rioux, Rinse K Weersma, Andre Franke, Luke Jostins, Carl A Anderson, Jeffrey C Barrett, Daniel G MacArthur, Chaim Jalas, Harry Sokol, Ramnik J Xavier, Ann Pulver, Judy H Cho, Dermot P B McGovern, Mark J Daly
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007329 (2018)
As part of a broader collaborative network of exome sequencing studies, we developed a jointly called data set of 5,685 Ashkenazi Jewish exomes. We make publicly available a resource of site and allele frequencies, which should serve as a reference f
Externí odkaz:
https://doaj.org/article/36415c854cfc4f458bf1a4f15bcfe6f2
Autor:
Tuomo J Meretoja, Ruixian Liu, Diether Lambrechts, Johanna Mattson, Satu Mustjoki, Päivi Saavalainen, Bram Boeckx, Maija Hollmen, Rita Turpin, Pauliina M Munne, Aino Peura, Jenna H Rannikko, Gino Philips, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova, July Aung, Elisa M Vuorinen, Laura Lehtinen, Minna Mutka, Panu E Kovanen, Laura Niinikoski, Andrei Goga, Jeroen Pouwels, Juha Klefström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on the tumor immune microenvironment (TIME). Therefore, there is a c
Externí odkaz:
https://doaj.org/article/cffa2828cea442bea9cecbc2dda3a9f7
Publikováno v:
Advanced Materials Interfaces, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract Superhydrophilic/superhydrophobic patterned surfaces can be used to create droplet microarrays. A specific challenge with the liquids needed for various biomedical applications, as compared to pure water, is their lower surface tension and p
Externí odkaz:
https://doaj.org/article/44e15b76cbd24515a16ad3d6293d491b
Autor:
Christopher Jonkergouw, Ngong Kodiah Beyeh, Ekaterina Osmekhina, Katarzyna Leskinen, S. Maryamdokht Taimoory, Dmitrii Fedorov, Eduardo Anaya-Plaza, Mauri A. Kostiainen, John F. Trant, Robin H. A. Ras, Päivi Saavalainen, Markus B. Linder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The limited diversity in targets of available antibiotic therapies has put tremendous pressure on the treatment of bacterial pathogens, where numerous resistance mechanisms that counteract their function are becoming increasingly prevalent.
Externí odkaz:
https://doaj.org/article/ce32b3bb75ca43ada00bf2e937ef276d
Autor:
Johannes Virta, Markus Hannula, Katri Lindfors, Ilmari Tamminen, Juha Taavela, Heini Huhtala, Katri Kaukinen, Päivi Saavalainen, Jari Hyttinen, Kalle Kurppa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundDuodenal histology remains the diagnostic reference standard in celiac disease. However, traditional methods have suboptimal sensitivity and reproducibility for early mucosal changes and research purposes. We validated a recently introduced
Externí odkaz:
https://doaj.org/article/3455877ef3844826bfe75d6a9341d36e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Varying HLA allele-specific expression levels are associated with human diseases, such as graft versus host disease (GvHD) in hematopoietic stem cell transplantation (HSCT), cytotoxic T cell response and viral load in HIV infection, and the risk of C
Externí odkaz:
https://doaj.org/article/f3a919bae9d54ee9a88b95d90502353c
Autor:
Samineh Barmaki, Ahmed Al-Samadi, Katarzyna Leskinen, Wafa Wahbi, Ville Jokinen, Sanna Vuoristo, Tuula Salo, Juha Kere, Satu Wedenoja, Päivi Saavalainen
Publikováno v:
Biomaterials and Biosystems, Vol 7, Iss , Pp 100056- (2022)
Oxygen tension varies during placental and fetal development. Although hypoxia drives early trophoblast invasion, low placental oxygen levels during pregnancy show association with pregnancy complications including fetal growth restriction and preecl
Externí odkaz:
https://doaj.org/article/532c033c74504552b426d5f23180ff6c
Autor:
Man Xu, Katarzyna Leskinen, Tommaso Gritti, Valerija Groma, Johanna Arola, Anna Lepistö, Taina Sipponen, Päivi Saavalainen, Maria Söderlund-Venermo
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Parvoviruses are single-stranded DNA viruses, infecting many animals from insects to humans. Human parvovirus B19 (B19V) causes erythema infectiosum, arthropathy, anemia, and fetal death, and human bocavirus (HBoV) 1 causes respiratory tract infectio
Externí odkaz:
https://doaj.org/article/4b0103babe764f779015f79a0c55d750
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Deep immune receptor sequencing, RepSeq, provides unprecedented opportunities for identifying and studying condition-associated T-cell clonotypes, represented by T-cell receptor (TCR) CDR3 sequences. However, due to the immense di
Externí odkaz:
https://doaj.org/article/8e7f150415f54117beec7e3a01ff5c82