Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paivi Jaana Kukkola"'
Autor:
Paivi Jaana Kukkola, Suraj S. Shetty, Natalie A. Bilci, Paula Savage, Theodore Ikler, Arco Y. Jeng, Dominick DelGrande
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1737-1740
1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6e1f77d9a18d7b3a45f6a318e01761
https://doi.org/10.1016/s0960-894x(01)00273-6
https://doi.org/10.1016/s0960-894x(01)00273-6
Publikováno v:
Tetrahedron Letters. 37:5065-5068
The described synthesis of isomeric isoindoline dicarboxylic acid analogs 1 and 2, two potent ETA selective receptor antagonists, involves an efficient regioselective route to highly functionalized dibenzoylbenzenes and a novel methodology for the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b68ee7bcb04b05b8040e3d99eab9837
https://doi.org/10.1016/0040-4039(96)01018-0
https://doi.org/10.1016/0040-4039(96)01018-0
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:619-624
The structural requirements of retro-thiorphan, N -[1 R , S -benzyl-2-mercaptoethyl]malonamic acid 2 , analogs for the inhibition of endothelin converting enzyme (ECE) were investigated. Although based on a single amino acid residue, N -[1 R -(1 H -i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::192d2b41984e1f6d7218fbdb6cff3eae
https://doi.org/10.1016/0960-894x(96)00091-1
https://doi.org/10.1016/0960-894x(96)00091-1
Publikováno v:
Biochemical Pharmacology. 49:291-296
The enzyme responsible for the conversion of exogenous big endothelindash1 to endothelindash1 by porcine coronary arterial smooth muscle has been shown to be a metalloprotease. The potencies of eight metalloprotease inhibitors for this endothelindash
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67907a12f553e98760be8e28d511e66d
https://doi.org/10.1016/0006-2952(94)00508-j
https://doi.org/10.1016/0006-2952(94)00508-j
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:S65-68
The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE) were compared. Phosphoramidon inhibited ECE, NEP, and AC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c614f7d14c6db2a27d6802d12d11b86
https://doi.org/10.1097/00005344-199506263-00021
https://doi.org/10.1097/00005344-199506263-00021
Publikováno v:
ChemInform. 27
The described synthesis of isomeric isoindoline dicarboxylic acid analogs 1 and 2, two potent ETA selective receptor antagonists, involves an efficient regioselective route to highly functionalized dibenzoylbenzenes and a novel methodology for the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a9f804ece20eb75aff2a9f9bb6e9f6
https://doi.org/10.1002/chin.199643086
https://doi.org/10.1002/chin.199643086
Autor:
Arco Y. Jeng, Dominick DelGrande, Natalie A. Bilci, Paula Savage, Paivi Jaana Kukkola, Suraj S. Shetty, Theodore Ikler
Publikováno v:
ChemInform. 32
1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c242b0772da276445eea28df4233ef0d
https://doi.org/10.1002/chin.200147099
https://doi.org/10.1002/chin.200147099
Autor:
David Louis Feldman, Randy L. Webb, Warren Lee, Ashok Hospattankar, Michael Jeune, Alan D. Neubert, Natalie A. Bilci, Natalya Alexander, Andrew M. Yuan, Therese C Mogelesky, Aida E. Navarrete, Gary Michael Ksander, Joyce C. Gibson, Eric Carlson, Haamid M. Sharif, Eli M. Wallace, Jong Wasvery, Reynalda Dejesus, Paivi Jaana Kukkola, Edna Cahill, Michael A. Moskal, Cynthia A. Fink, Steele Ronald Edward, Zouhair F. Stephan, Kevin Poirier
Publikováno v:
Journal of medicinal chemistry. 44(26)
The synthesis and biological activities of biarylamide-substituted diaminoindanes as microsomal triglyceride transfer protein (MTP) inhibitors are described. One of the more potent compounds, 8aR, inhibited both the secretion of apoB from Hep G2 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0586d5545b1198cefd0a15bfddbac44
https://pubmed.ncbi.nlm.nih.gov/11741485
https://pubmed.ncbi.nlm.nih.gov/11741485