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Long-term Safety and Efficacy of Mirabegron and Solifenacin in Combination Compared with Monotherapy in Patients with Overactive Bladder: A Randomised, Multicentre Phase 3 Study (SYNERGY II)

Autor: Sang Jin Yoon, Asha Paireddy, Tomasz Rechberger, Salman Al-Shukri, Dudley Robinson, Arwin Ridder, Sender Herschorn, Christopher R. Chapple, Matthias Stoelzel, Rob van Maanen, Paul Abrams, Christian Gratzke, Elizabeth R. Mueller

Publikováno v: European Urology. 74:501-509

Background The long-term potential of solifenacin and mirabegron combination treatment for patients with overactive bladder (OAB) has not been previously assessed. Objectives To evaluate the safety and efficacy of solifenacin succinate 5mg plus mirab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c85f7a85780ece96b72ab909dd4f6043
https://doi.org/10.1016/j.eururo.2018.05.005

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Cardiovascular Safety of the β3-Adrenoceptor Agonist Mirabegron and the Antimuscarinic Agent Solifenacin in the SYNERGY Trial

Autor: Asha Paireddy, Christian Gratzke, Michael A. Weber, Jeffrey Frankel, Matthias Stoelzel, Arwin Ridder, Dudley Robinson, Christopher R. Chapple, Robert van Maanen, Sender Herschorn, William B. White

Publikováno v: The Journal of Clinical Pharmacology. 58:1084-1091

There have been concerns that treatment of overactive bladder with β3 -adrenoceptor agonists may potentially have detrimental cardiovascular (CV) side effects. We evaluated the CV safety of mirabegron, a β3 -adrenoceptor agonist, alone and in combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1ea6d90c44e662fee6815cb7e774854
https://doi.org/10.1002/jcph.1107

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A strategy utilizing ambulatory monitoring and home and clinic blood pressure measurements to optimize the safety evaluation of noncardiovascular drugs with potential for hemodynamic effects: a report from the SYNERGY trial

Autor: Asha Paireddy, Arwin Ridder, Michael A. Weber, Sender Herschorn, Dudley Robinson, Jeffrey Frankel, Christopher R. Chapple, Robert van Maanen, William B. White, Matthias Stoelzel, Christian Gratzke

Publikováno v: Blood Pressure Monitoring

Supplemental Digital Content is available in the text.
Objective The aim of this study was to perform a blood pressure (BP) safety evaluation in patients with an overactive bladder receiving solifenacin (an antimuscarinic agent), mirabegron (a �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a22857cb70afb10268b3db4f7c24cf
https://pubmed.ncbi.nlm.nih.gov/29578880

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Electronic bladder diaries of differing duration versus a paper diary for data collection in overactive bladder

Autor: Trudy Kuipers-deGroot, Asha Paireddy, Rob van Maanen, Reynaldo Martina, Arwin Ridder, Donald Newgreen, Jean Paty, Paul Abrams

Publikováno v: Neurourology and Urodynamics. 35:743-749

Aims This observational study compared data values, reliability, consistency and compliance collected by electronic and paper diaries of differing durations. Methods Subjects ≥18 years with overactive bladder (OAB) on stable antimuscarinic treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2627d9e20a842d3ef465bfcd3ecf87be
https://doi.org/10.1002/nau.22800

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Cardiovascular Safety of the β

Autor: William B, White, Christopher, Chapple, Christian, Gratzke, Sender, Herschorn, Dudley, Robinson, Jeffrey, Frankel, Arwin, Ridder, Matthias, Stoelzel, Asha, Paireddy, Robert, van Maanen, Michael A, Weber

Publikováno v: Journal of clinical pharmacologyReferences. 58(8)

There have been concerns that treatment of overactive bladder with β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2bb9e550dc18ef718ae22da9ba6cd30
https://pubmed.ncbi.nlm.nih.gov/29645285

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PNFLBA-09 LONG-TERM COMBINATION TREATMENT WITH SOLIFENACIN AND MIRABEGRON IS EFFECTIVE AND WELL TOLERATED IN PATIENTS WITH OVERACTIVE BLADDER

Autor: Christopher R. Chapple, Elizabeth R. Mueller, Arwin Ridder, Christian Gratzke, Sender Herschorn, Paul Abrams, Matthias Stoelzel, Rob van Maanen, Dudley Robinson, Asha Paireddy

Publikováno v: Journal of Urology. 197

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88e1cfe211766c38e0227f554901c478
https://doi.org/10.1016/j.juro.2017.03.073

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Efficacy and safety of combinations of mirabegron and solifenacin compared with monotherapy and placebo in patients with overactive bladder (SYNERGY study)

Autor: Matthias Stoelzel, Arwin Ridder, Kyu-Sung Lee, Salvador Arlandis, Dudley Robinson, Sender Herschorn, Rob van Maanen, David Mitcheson, Asha Paireddy, Christopher R. Chapple, Paul Abrams

Publikováno v: BJU INTERNATIONAL
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Objective To evaluate the potential of solifenacin 5 mg combined with mirabegron 25 or 50 mg to deliver superior efficacy compared with monotherapy, with acceptable tolerability, in the general overactive bladder (OAB) population with urinary inconti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62156a3e09ef9703a15e820dd0eb4426
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6867

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