Výsledky vyhledávání - "Paired Box Transcription Factors/metabolism"

Cell-specific alterations in Pitx1 regulatory landscape activation caused by the loss of a single enhancer

Autor: Raquel Rouco, Olimpia Bompadre, Antonella Rauseo, Olivier Fazio, Rodrigue Peraldi, Fabrizio Thorel, Guillaume Andrey

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, Vol. 12, No 1 (2021) P. 7235

Developmental genes are frequently controlled by multiple enhancers sharing similar specificities. As a result, deletions of such regulatory elements have often failed to reveal their full function. Here, we use the Pitx1 testbed locus to characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b5a53a17c83d09b92f2147f4291ae1
http://europepmc.org/articles/PMC8668926

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Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex

Autor: John L.R. Rubenstein, Luis Puelles, Leila Taher, Axel Visel, Kartik Pattabiraman, Shanni N. Silberberg, Alexander Nord, Bin Chen, Dongji Zhang, Len A. Pennacchio, Susan Lindtner, Hong Kui Zeng, Olga Golonzhka, Renée V. Hoch

Publikováno v: Neuron, vol 82, iss 5

Elucidating the genetic control of cerebral cortical (pallial) development is essential for understanding function, evolution, and disorders of the brain. Transcription factors (TFs) that embryonically regulate pallial regionalization are expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22153019a73009cba75e34c2aeeb42ef
https://doi.org/10.1016/j.neuron.2014.04.014

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JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells

Autor: David Olmos, Zoë S. Walters, Edoardo Missiaglia, Bissan Al-Lazikani, Julian Blagg, Thomas Ws Buist, Michelle D. Garrett, Rebecca Allen, Janet Shipley, Barbara Villarejo-Balcells

Publikováno v: Oncogene
Oncogene, vol. 33, no. 9, pp. 1148-1157

Rhabdomyosarcomas (RMS) are the most frequent soft-tissue sarcoma in children and\ud characteristically show features of developing skeletal muscle. The alveolar subtype is frequently\ud associated with a PAX3-FOXO1 fusion protein that is known to co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6de3048cd3fbce55d8e97a5eabd4072
http://europepmc.org/articles/PMC3982124

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In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

Autor: Asllan Gjinovci, Carmen M. Jimenez Moreno, Claes B. Wollheim, Kai Hui Hu He, Deborah Aeberhard, Fabrizio Thorel, Marion Cornu, Benoit R. Gauthier, Petra I. Lorenzo, Jorge Vallejo Ortega, Pedro Luis Herrera, Thierry Brun, Bernard Thorens, Paolo Meda

Publikováno v: Diabetes
Diabetes, Vol. 60, No 6 (2011) pp. 1705-15
Diabetes; Vol 60
Diabetes, vol. 60, no. 6, pp. 1705-1715
Digital.CSIC. Repositorio Institucional del CSIC
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et al.
[Objective]: To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43996fb6545ff2cf025baf9d4ab3104
https://doi.org/10.2337/db10-1102

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Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation

Autor: Silvia Sorce, Brian Victor Beck, Jérôme Bonnefont, Karl-Heinz Krause, Colette Dehay, Olivier Plastre, Térèse Laforge

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Vol. 18, No 2 (2011) pp. 293-303

Ret finger protein-like 1 (RFPL1) is a primate-specific target gene of Pax6, a key transcription factor for pancreas, eye and neocortex development. However, its cellular activity remains elusive. In this article, we report that Pax6-elicited express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c993c35d16646c91661c29dd06de74

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A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and disease

Autor: Benoit R. Gauthier, Thierry Brun

Publikováno v: Journal of molecular endocrinology, Vol. 40, No 2 (2008) pp. 37-45

Blood glucose homeostasis is achieved by the regulation of insulin and glucagon secretion from the pancreatic islet beta- and alpha-cells. Diabetes mellitus, which comprises a heterogeneous group of hyperglycaemic disorders, results mainly from inade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a9d664674df29d4e59bac7fc7511ac
https://archive-ouverte.unige.ch/unige:851

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Deletion of the RNaseIII Enzyme Dicer in Thyroid Follicular Cells Causes Hypothyroidism with Signs of Neoplastic Alterations

Autor: Christophe E. Pierreux, Anne-Christine Hick, Véronique Janssens, Ling Jin, Sabine Costagliola, Eneko Urizar, Wendy Rodriguez

Publikováno v: PLoS ONE
PloS one, 7 (1
PLoS One, Vol. 7, no. 1, p. e29929 (2012)
PLoS ONE, Vol 7, Iss 1, p e29929 (2012)

Micro-RNAs (miRNAs) are small non-coding RNAs that regulate gene expression, mainly at mRNA post-transcriptional level. Functional maturation of most miRNAs requires processing of the primary transcript by Dicer, an RNaseIII-type enzyme. To date, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7d552a746de5248e35c00bcd7f28dd
https://doi.org/10.1371/journal.pone.0029929

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A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells

Autor: Stéphanie Julien, David M. Suter, Diderik Tirefort, Karl-Heinz Krause

Publikováno v: Stem Cells, Vol. 27, No 1 (2009) pp. 49-58

The transcription factors Sox1 and Pax6 are expressed sequentially during early mouse embryonic neurogenesis. Sox1 expression starts upon formation of neuroectoderm, whereas Pax6 is subsequently expressed in radial glial cells, the latter giving rise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f9554592d4014a705ccfa8238c79a5
https://infoscience.epfl.ch/record/186613

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