The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice.

Autor: Pessentheiner AR; Department of Medicine, UCSD, La Jolla, California, USA.; Institute of Molecular Biosciences, University of Graz, Graz, Austria., Spann NJ; Department of Cellular and Molecular Medicine and., Autran CA; Department of Pediatrics at UCSD, La Jolla, California, USA., Oh TG; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA., Grunddal KV; Department of Medicine, UCSD, La Jolla, California, USA., Coker JK; Department of Medicine, UCSD, La Jolla, California, USA.; Department of Bioengineering at UCSD, La Jolla, California, USA., Painter CD; Department of Medicine, UCSD, La Jolla, California, USA., Ramms B; Department of Medicine, UCSD, La Jolla, California, USA., Chiang AW; Department of Pediatrics at UCSD, La Jolla, California, USA.; Department of Bioengineering at UCSD, La Jolla, California, USA.; Novo Nordisk Foundation Center for Biosustainability, La Jolla, California, USA., Wang CY; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIH Research Oxford Biomedical Research Unit (BRU), and.; Oxford Centre for Translational Myeloma Research University of Oxford, Oxford, United Kingdom., Hsiao J; Department of Medicine, UCSD, La Jolla, California, USA., Wang Y; Department of Medicine, UCSD, La Jolla, California, USA., Quach A; Department of Medicine, UCSD, La Jolla, California, USA., Booshehri LM; Department of Pediatrics at UCSD, La Jolla, California, USA., Hammond A; Department of Pediatrics at UCSD, La Jolla, California, USA., Tognaccini C; Department of Medicine, UCSD, La Jolla, California, USA., Latasiewicz J; Department of Pediatrics at UCSD, La Jolla, California, USA., Willemsen L; Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands., Zengler K; Department of Bioengineering at UCSD, La Jolla, California, USA.; Center for Microbiome Innovation, UCSD, La Jolla, California, USA., de Winther MP; Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands., Hoffman HM; Department of Medicine, UCSD, La Jolla, California, USA.; Department of Pediatrics at UCSD, La Jolla, California, USA.; Rady Children's Hospital of San Diego, San Diego, California, USA., Philpott M; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIH Research Oxford Biomedical Research Unit (BRU), and., Cribbs AP; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIH Research Oxford Biomedical Research Unit (BRU), and.; Oxford Centre for Translational Myeloma Research University of Oxford, Oxford, United Kingdom., Oppermann U; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIH Research Oxford Biomedical Research Unit (BRU), and.; Oxford Centre for Translational Myeloma Research University of Oxford, Oxford, United Kingdom., Lewis NE; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.; Department of Bioengineering at UCSD, La Jolla, California, USA.; Novo Nordisk Foundation Center for Biosustainability, La Jolla, California, USA., Witztum JL; Department of Medicine, UCSD, La Jolla, California, USA., Yu R; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA., Atkins AR; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA., Downes M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA., Evans RM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA., Glass CK; Department of Medicine, UCSD, La Jolla, California, USA.; Department of Cellular and Molecular Medicine and., Bode L; Department of Pediatrics at UCSD, La Jolla, California, USA.; Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE) and.; Glycobiology Research and Training Center, UCSD, La Jolla, California, USA., Gordts PL; Department of Medicine, UCSD, La Jolla, California, USA.; Glycobiology Research and Training Center, UCSD, La Jolla, California, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Nov 08; Vol. 9 (21). Date of Electronic Publication: 2024 Nov 08.

Vascular Proteome Responses Precede Organ Dysfunction in a Murine Model of Staphylococcus aureus Bacteremia.

Autor: Sorrentino JT; Bioinformatics and Systems Biology Graduate Program, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; Department of Bioengineering, University of California, San Diegogrid.266100.3, La Jolla, California, USA., Golden GJ; Department of Cellular and Molecular Medicine, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; Glycobiology Research and Training Center, University of California, San Diegogrid.266100.3, La Jolla, California, USA., Morris C; Department of Cellular and Molecular Medicine, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; Glycobiology Research and Training Center, University of California, San Diegogrid.266100.3, La Jolla, California, USA., Painter CD; Department of Cellular and Molecular Medicine, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; Glycobiology Research and Training Center, University of California, San Diegogrid.266100.3, La Jolla, California, USA., Nizet V; Department of Pediatrics, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diegogrid.266100.3, La Jolla, California, USA., Campos AR; The Cancer Center and The Inflammatory and Infectious Disease Center, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, USA., Smith JW; The Cancer Center and The Inflammatory and Infectious Disease Center, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, USA., Karlsson C; Department of Clinical Sciences, Division of Infection Medicine, Lund Universitygrid.4514.4, BMC, Lund, Sweden., Malmström J; Department of Clinical Sciences, Division of Infection Medicine, Lund Universitygrid.4514.4, BMC, Lund, Sweden., Lewis NE; Department of Bioengineering, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; Department of Pediatrics, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; National Biologics Facility, Technical University of Denmark, Krogens-Lyngby, Denmark., Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diegogrid.266100.3, La Jolla, California, USA.; Glycobiology Research and Training Center, University of California, San Diegogrid.266100.3, La Jolla, California, USA., Gómez Toledo A; Department of Clinical Sciences, Division of Infection Medicine, Lund Universitygrid.4514.4, BMC, Lund, Sweden.

Publikováno v: MSystems [mSystems] 2022 Aug 30; Vol. 7 (4), pp. e0039522. Date of Electronic Publication: 2022 Aug 01.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.

Autor: Clausen TM; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Infectious Disease, Copenhagen University Hospital, 2200 Copenhagen, Denmark. Electronic address: tmandelclausen@health.ucsd.edu., Sandoval DR; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Spliid CB; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Infectious Disease, Copenhagen University Hospital, 2200 Copenhagen, Denmark., Pihl J; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Infectious Disease, Copenhagen University Hospital, 2200 Copenhagen, Denmark., Perrett HR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Painter CD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA., Narayanan A; Department of Biochemistry and Molecular Biology, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA., Majowicz SA; Department of Biochemistry and Molecular Biology, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA., Kwong EM; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., McVicar RN; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Thacker BE; TEGA Therapeutics, Inc., 3550 General Atomics Court, G02-102, San Diego, CA 92121, USA., Glass CA; TEGA Therapeutics, Inc., 3550 General Atomics Court, G02-102, San Diego, CA 92121, USA., Yang Z; Copenhagen Center for Glycomics, Department of Molecular and Cellular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Golden GJ; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA., Bartels PL; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA., Porell RN; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA., Garretson AF; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA., Laubach L; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA., Feldman J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Yin X; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA., Pu Y; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA., Hauser BM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Caradonna TM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Kellman BP; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA., Martino C; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA., Gordts PLSM; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA., Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA., Schmidt AG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA., Godula K; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA., Leibel SL; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA., Jose J; Department of Biochemistry and Molecular Biology, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA., Corbett KD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Carlin AF; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA., Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jesko@health.ucsd.edu.

Publikováno v: Cell [Cell] 2020 Nov 12; Vol. 183 (4), pp. 1043-1057.e15. Date of Electronic Publication: 2020 Sep 14.

Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein.

Autor: Sandoval DR; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093., Gomez Toledo A; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093., Painter CD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093., Tota EM; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093., Sheikh MO; Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602., West AMV; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093., Frank MM; Biognos AB, 417 05 Göteborg, Sweden., Wells L; Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602., Xu D; Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York 14214., Bicknell R; College of Medicine and Dentistry, University of Birmingham, Birmingham B15 2TT, United Kingdom., Corbett KD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093., Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093. Electronic address: jesko@ucsd.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Feb 28; Vol. 295 (9), pp. 2804-2821. Date of Electronic Publication: 2020 Jan 21.