Výsledky vyhledávání - "Paine, M. F."

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Mechanistic Basis of Altered Morphine Disposition in Nonalcoholic Steatohepatitis

Autor: Paine, M. F., Cherrington, N. J., Hargraves, T. L., Vanderah, T. W., Dzierlenga, A. L., Clarke, J. D., Ainslie, G. R.

Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug resistance-associated proteins Mrp3 and Mrp2, loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0583ac827fe56f4520fb2458252afca

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Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

Autor: Stewart, P. W., Johnston, C. K., Ferslew, B. C., Jia, W., Brouwer, K. L.R., Tsakalozou, E., Barritt, A. S., Paine, M. F., Bridges, A. S.

The functional impact of altered drug transport protein expression on the systemic pharmacokinetics of morphine, hepatically-derived morphine glucuronide (morphine-3- and morphine-6-glucuronide), and fasting bile acids was evaluated in patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e36b648da52ce7612607122aee60084a

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Akademický článek

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Akademický článek

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Herb-Drug Interactions: Challenges and Opportunities for Improved Predictions

Autor: Paine, M. F., Nagar, S., Lin, Y. S., Argikar, A. A., Brantley, S. J.

Supported by a usage history that predates written records and the perception that “natural” ensures safety, herbal products have increasingly been incorporated into Western health care. Consumers often self-administer these products concomitantl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac750ab0c10db22ddc5d84222f6e45ff

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Assessment of a Candidate Marker Constituent Predictive of a Dietary Substance-Drug Interaction: Case Study with Grapefruit Juice and CYP3A4 Drug Substrates

Autor: Li, Y., Paine, M. F., Scarlett, Y. V., Ainslie, G. R., Hull, J. H., Wolf, K. K., Connolly, E. A.

Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary substance–drug interaction assessment are lacking. This deficiency is due in part to challe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f3fa5f2a45320b76dda466e897e7471

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Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation

Autor: Paine, M. F., Wienkers, L. C., Bridges, A. S., Connolly, E. A., Gonzalez-Perez, V.

(S)-Warfarin 7-hydroxylation and midazolam 1′-hydroxylation are among the preferred probe substrate reactions for CYP2C9 and CYP3A4/5, respectively. The impact of solvents on enzyme activity, kinetic parameters, and predicted in vivo hepatic cleara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f12a06f39cde320466b2a7265ecb700

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A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair

Autor: Hall, J. E., Generaux, C. N., Goldsmith, R. B., Tidwell, R. R., Olson, C. A., Paine, M. F., Clewell, H. J., Brouwer, K. L. R., Yan, G. Z., Yoon, M.

Dose selection during antiparasitic drug development in animal models and humans traditionally has relied on correlations between plasma concentrations obtained at or below maximally tolerated doses that are efficacious. The objective of this study w

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Mechanisms Underlying Differences in Systemic Exposure of Structurally Similar Active Metabolites: Comparison of Two Preclinical Hepatic Models

Autor: Paine, M. F., Tidwell, R. R., Wang, M. Z., Brouwer, K. L. R., Pollack, G. M., Yan, G. Z., Hall, J. E.

Selection of in vitro models that accurately characterize metabolite systemic and hepatobiliary exposure remains a challenge in drug development. In the present study, mechanisms underlying differences in systemic exposure of two active metabolites,

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