Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paige S Dunphy"'
Autor:
Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn H. Kasper, Junyuan Zhang, Xiaoyu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Yingzhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh A. Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick Boop, Amar Gajjar, Jinghui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman III, Martine F. Roussel, Paul A. Northcott, Taosheng Chen, Zoran Rankovic, Gang Wu, Jason Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Patient-derived xenografts provide a resource for basic and translational cancer research. Here, the authors generate multiple pediatric high-grade glioma xenografts, use omics technologies to show that they are representative of primary tumours and
Externí odkaz:
https://doaj.org/article/879be8929790465bbe548678fef6db02
Autor:
Valerie J Klema, Krishna Mohan Sepuru, Nadia Füllbrunn, Tierra R Farris, Paige S Dunphy, Jere W McBride, Krishna Rajarathnam, Kyung H Choi
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194891 (2018)
Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis, secretes several effector proteins that bind host DNA to modulate host gene expression. The tandem repeat protein 120 (TRP120), one of the largest effector proteins, has
Externí odkaz:
https://doaj.org/article/323364a3ba5543abb73cfd9c9cb18991
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Ehrlichia chaffeensis infects mononuclear phagocytes and survives intracellularly by exploiting host cell processes to evade host defenses. The mechanisms involved are not fully defined, but appear to rely largely on a subset of tandem repeat protein
Externí odkaz:
https://doaj.org/article/570abf8828894bdb8e73f72609c7738a
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT Ehrlichia chaffeensis preferentially targets mononuclear phagocytes and survives through a strategy of subverting innate immune defenses, but the mechanisms are unknown. We have shown E. chaffeensis type 1 secreted tandem repeat protein (TRP
Externí odkaz:
https://doaj.org/article/a3a41c4f93ec4b9f9e3f5f7d348d0abb
Autor:
Amar Gajjar, Jinghui Zhang, Yingzhe Wang, Xiaoyan Zhu, William Caufield, Chen He, Xiaoyu Li, Burgess B. Freeman, Zoran Rankovic, Gang Wu, Michelle Monje, Nathaniel R. Twarog, Duane G. Currier, Taosheng Chen, Kimberly S Mercer, Barbara Jonchere, Jason Chiang, Ke Xu, Lawryn H. Kasper, Jia Xie, Laura D. Hover, Ibrahim Qaddoumi, Christopher L. Tinkle, Cynthia Wetmore, Wenwei Lin, Anang A. Shelat, Paul Klimo, Giles W. Robinson, Santhosh A. Upadhyaya, Suzanne J. Baker, Brent A. Orr, Alberto Broniscer, Frederick A. Boop, Paige S. Dunphy, Martine F. Roussel, Paul A. Northcott, Brian Gudenas, Chang-Hyuk Kwon, James T. Dalton, Junyuan Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children. In vitro and in vivo disease models reflecting the intimate connection between developmental context and pathogenesis of pHGG are essential to advance unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b378e78d205642842686c121971441
http://europepmc.org/articles/PMC8253809
http://europepmc.org/articles/PMC8253809
Autor:
Chen He, Brian Gudenas, James Dalton, Jason Chiang, Zoran Rankovic, Chang-Hyuk Kwon, Nathaniel R. Twarog, Wenwei Lin, Amar Gajjar, Michelle Monje, Ke Xu, Lawryn H. Kasper, Laura D. Hover, Brent A. Orr, Taosheng Chen, Burgess B. Freeman, Gang Wu, Kimberly S Mercer, Santhosh A. Upadhyaya, Paul Klimo, Yingzhe Wang, Giles W. Robinson, William Caufield, Paige S. Dunphy, Martine F. Roussel, Suzanne J. Baker, Ibrahim Qaddoumi, Cynthia Wetmore, Xiaoyu Li, Jinghui Zhang, Anang A. Shelat, Duane G. Currier, Barbara Jonchere, Christopher L. Tinkle, Paul A. Northcott, Alberto Broniscer, Frederick A. Boop, Junyuan Zhang, Xiaoyan Zhu
Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children.In vitroandin vivodisease models reflecting the intimate connection between developmental context and pathogenesis of pHGG are essential to advance understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50126b367618675b8183d0d1f1bd54c
https://doi.org/10.1101/2020.12.06.407973
https://doi.org/10.1101/2020.12.06.407973
Autor:
Michael DeCupyere, Santhosh A Upadayaya, Gang Wu, Thomas E. Merchant, David W. Ellison, Frederick A. Boop, Suzanne J. Baker, Paige S. Dunphy, Martine F. Roussel, Brent A. Orr, Kimberly S Mercer, Sarah Robinson, Kyle S. Smith, Jose Grenet, Paul Klimo, Giles W. Robinson, Paul A. Northcott, Amar Gajjar, Ke Xu
Publikováno v:
Acta Neuropathologica
Pediatric brain tumors are the leading cause of cancer-related death in children. Patient-derived orthotopic xenografts (PDOX) of childhood brain tumors have recently emerged as a biologically faithful vehicle for testing novel and more effective the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa23e487f4ac5e923a13af6f16d7f96
https://pubmed.ncbi.nlm.nih.gov/32519082
https://pubmed.ncbi.nlm.nih.gov/32519082
Autor:
Michael A. Dyer, Brandon McMahan, Ashok K. Boddu, Clay McLeod, Frederick A. Boop, Edgar Sioson, Xiaoyan Zhu, Paige S. Dunphy, Martine F. Roussel, Swapnali Mohite, Chen He, Darrell T. Gentry, Kyle S. Smith, Jason Chiang, Irina McGuire, Paul A. Northcott, Daniel Alford, Christopher L. Tinkle, Austyn Trull, Kimberly S Mercer, Paul Klimo, Giles W. Robinson, Sarah Robinson, Nathaniel R. Twarog, Suzanne J. Baker, J. Robert Michael, Junyuan Zhang, Anthony Woodard, Brent A. Orr, Jinghui Zhang, Nedra Robison, Cynthia Williams, Keith Perry, Aksana Vasilyeva, Anang A. Shelat, Brian Gudenas, Chang-Hyuk Kwon, Kirby Birch, Amar Gajjar, Xin Zhou, Ke Xu, Lawryn H. Kasper, Laura D. Hover, Gang Wu, Ed Suh, Jon D. Larson
Publikováno v:
Cancer Research. 80:6144-6144
Pediatric brain tumors comprise a distinct spectrum of diseases compared to adult brain tumors and are distinguished by their unique clinical and histopathological features, developmental context, mutation burden, and genomic, epigenomic, and transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df3dc4d8c1bfdcc93b50e3c02e429f9
https://doi.org/10.1158/1538-7445.am2020-6144
https://doi.org/10.1158/1538-7445.am2020-6144
Publikováno v:
Infection and Immunity. 84:3182-3194
Ehrlichia chaffeensis is an obligately intracellular bacterium that reprograms the mononuclear phagocyte through diverse effector-host interactions to modulate numerous host cell processes, including transcription. In a previous study, we reported th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49950daff05c0bd4676c08d09d455a3b
https://doi.org/10.1128/iai.00657-16
https://doi.org/10.1128/iai.00657-16
Publikováno v:
Infection and Immunity. 82:4154-4168
Ehrlichia chaffeensis is an obligately intracellular Gram-negative bacterium that selectively infects mononuclear phagocytes. We recently reported that E. chaffeensis utilizes a type 1 secretion (T1S) system to export tandem repeat protein (TRP) effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe38fa55fae6c67c050b8ff543b32c4b
https://doi.org/10.1128/iai.01984-14
https://doi.org/10.1128/iai.01984-14