Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paige M E, Hawkins"'
Autor:
Alexander Norman, Charlotte Franck, Mary Christie, Paige M. E. Hawkins, Karishma Patel, Anneliese S. Ashhurst, Anupriya Aggarwal, Jason K. K. Low, Rezwan Siddiquee, Caroline L. Ashley, Megan Steain, James A. Triccas, Stuart Turville, Joel P. Mackay, Toby Passioura, Richard J. Payne
Publikováno v:
ACS Central Science, Vol 7, Iss 6, Pp 1001-1008 (2021)
Externí odkaz:
https://doaj.org/article/0a46d203a8ab4df88c42556e3ac1d0dd
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e08cda86f6791396aa219a030366f02
https://doi.org/10.1021/acs.jmedchem.1c01407
https://doi.org/10.1021/acs.jmedchem.1c01407
Autor:
Anneliese S. Ashhurst, Caroline L. Ashley, K. Patel, Mary Christie, Anupriya Aggarwal, Charlotte Franck, Paige M. E. Hawkins, Alex Norman, Toby Passioura, James A. Triccas, Stuart Turville, Joel P. Mackay, Richard J. Payne, Jason Low, Megan Steain, Rezwan Siddiquee
Publikováno v:
ACS Central Science, Vol 7, Iss 6, Pp 1001-1008 (2021)
ACS Central Science
ACS Central Science
The COVID-19 pandemic, caused by SARS-CoV-2, has led to substantial morbidity, mortality, and disruption globally. Cellular entry of SARS-CoV-2 is mediated by the viral spike protein, and affinity ligands to this surface protein have the potential fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4b3f2e627c8cfb6f0198f88a1dbce5
https://doaj.org/article/0a46d203a8ab4df88c42556e3ac1d0dd
https://doaj.org/article/0a46d203a8ab4df88c42556e3ac1d0dd
Publikováno v:
Organic & Biomolecular Chemistry. 19:6291-6300
The total synthesis of the natural product coralmycin A/epi-coralmycin A, as well as a desmethoxy analogue is described. Synthesis was achieved via a divergent, bidirectional solid-phase strategy, including a key on-resin O-acylation, O to N acyl shi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342dd9c5264d8ddd4c3cf306d493c102
https://doi.org/10.1039/d1ob01062j
https://doi.org/10.1039/d1ob01062j
Autor:
Paige M. E. Hawkins, David M. Hoi, Chen-Yi Cheung, Trixie Wang, Diana Quan, Vishnu Mini Sasi, Dennis Y. Liu, Roger G. Linington, Colin J. Jackson, Stefan H. Oehlers, Gregory M. Cook, Warwick J. Britton, Tim Clausen, Richard J. Payne
Publikováno v:
Journal of medicinal chemistry. 65(6)
Ohmyungsamycin A and ecumicin are structurally related cyclic depsipeptide natural products that possess activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c7407a67bac14efae151a19bc11014
https://pubmed.ncbi.nlm.nih.gov/35293761
https://pubmed.ncbi.nlm.nih.gov/35293761
Autor:
Wendy, Tran, Ali S, Kusay, Paige M E, Hawkins, Chen-Yi, Cheung, Gayathri, Nagalingam, Venugopal, Pujari, Daniel J, Ford, Alexander, Stoye, Jessica L, Ochoa, Rebecca E, Audette, Elinor, Hortle, Stefan H, Oehlers, Susan A, Charman, Roger G, Linington, Eric J, Rubin, Christopher G, Dowson, David I, Roper, Dean C, Crick, Thomas, Balle, Gregory M, Cook, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 64(23)
Herein, we report the design and synthesis of inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00df1b626c713af803b1ee55c15e4b74
https://pubmed.ncbi.nlm.nih.gov/34845906
https://pubmed.ncbi.nlm.nih.gov/34845906
Publikováno v:
Organicbiomolecular chemistry. 19(28)
The total synthesis of the natural product coralmycin A/epi-coralmycin A, as well as a desmethoxy analogue is described. Synthesis was achieved via a divergent, bidirectional solid-phase strategy, including a key on-resin O-acylation, O to N acyl shi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::424df4d2a9d2da31d81d1fbd2ec50b14
https://pubmed.ncbi.nlm.nih.gov/34212970
https://pubmed.ncbi.nlm.nih.gov/34212970
Autor:
Gayathri Nagalingam, Richard J. Payne, Andrew M. Giltrap, Gregory M. Cook, Warwick J. Britton, Wendy Tran, Paige M. E. Hawkins, Chen-Yi Cheung
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 26(66)
The ohmyungsamycin and ecumicin natural product families are structurally related cyclic depsipeptides that display potent antimycobacterial activity. Herein the total syntheses of ohmyungsamycin A, deoxyecumicin, and ecumicin are reported, together
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe54aefdd6b4d2ad3a62a01a221a74b8
https://pubmed.ncbi.nlm.nih.gov/32567168
https://pubmed.ncbi.nlm.nih.gov/32567168
Autor:
Paige M. E. Hawkins, Warwick J. Britton, Andrew M. Giltrap, Richard J. Payne, Gayathri Nagalingam
Publikováno v:
Organic letters. 20(4)
The first total synthesis of the potent anti-mycobacterial cyclic depsipeptide natural product ecumicin is described. Synthesis was achieved via a solid-phase strategy, incorporating the synthetic non-proteinogenic amino acids N-methyl-4-methoxy-l-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c5062f2c2b653c5cd0419d63a32455
https://pubmed.ncbi.nlm.nih.gov/29412668
https://pubmed.ncbi.nlm.nih.gov/29412668