Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paige Holst"'
Autor:
Betsy Daugherty, Caroline Bishop, Chen Dong, Yongliang Zhang, Paige Holst, Ning Sun, Fred D. Lott, Yeonseok Chung, Andrew A. Welcher, Carole Kurahara, Hilary T. Chute
Publikováno v:
Proceedings of the National Academy of Sciences. 103:11695-11700
T cell activation and tolerance are regulated by costimulatory molecules. Although PD-1 serves as a crucial negative regulator of T cells, the function of its ligands, PDL1 and PDL2, is still controversial. In this study, we created a PDL2-deficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c51556f92c44957f51e1b2781eb91d
https://doi.org/10.1073/pnas.0601347103
https://doi.org/10.1073/pnas.0601347103
Autor:
Shuqian Jing, Paige Holst, Renping Zhou, Thomas C. Boone, Mei Fang, Gary M. Fox, John M. Delaney, Henry Schultz, Zheng Hu, Yanbin Yu
Publikováno v:
Journal of Biological Chemistry. 272:33111-33117
The receptor for glial cell line-derived neurotrophic factor (GDNF) consists of GFRα-1 and Ret. Neurturin is a GDNF-related neurotrophin whose receptor is presently unknown. Here we report that neurturin can bind to either GFRα-1 or GFRα-2, a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c75026f5765cc3d46521a7b4f714e47
https://doi.org/10.1074/jbc.272.52.33111
https://doi.org/10.1074/jbc.272.52.33111
Autor:
Paige Holst, Linda O. Narhi, Larry B. Tsai, Michael A. Weiss, James A. Miller, Tsutomu Arakawa, Robert Rosenfeld, Qing Xin Hua, G. Michael Fox
Publikováno v:
Biochemistry. 32:5214-5221
Insulin and insulin-related proteins contain three motif-specific disulfide bonds. Here we examine the role of these disulfide bonds in the folding and function of one family member, human insulin-like growth factor 1 (IGF-1). Analogues containing pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13de3959abaa323608cb0a766d47817
https://doi.org/10.1021/bi00070a033
https://doi.org/10.1021/bi00070a033
Autor:
Tsutomu Arakawa, Larry B. Tsai, Gary M. Fox, Douglas C. Rees, Tom Horan, Paige Holst, Susan G. Schiffer, Steven J. Prestrelski, Linda O. Narhi
Publikováno v:
"Protein Engineering, Design and Selection". 6:541-546
We have used recombinant DNA methods to produce two forms of bovine acidic fibroblast growth factor (aFGF), one with alanine substituted for the cysteine at position 47 and the other with the Ala47 change plus the substitution of glycine for the natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6966fdbcc3c3fb2156bfc46fa8c6626f
https://doi.org/10.1093/protein/6.5.541
https://doi.org/10.1093/protein/6.5.541
Autor:
Xiaotian Zhu, John S. Philo, Linda O. Narhi, Gary M. Fox, Steven J. Prestrelski, Tsutomu Arakawa, Jie Wen, Paige Holst, Douglas C. Rees
Publikováno v:
Journal of protein chemistry. 14(5)
High-affinity binding of basic fibroblast growth factor (bFGF) to the tyrosine kinase receptor requires cell-surface heparan sulfate proteoglycan or exogenous addition of heparin. The crystal structure of bFGF shows Arg40 and 45 on the surface opposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146e2422d317ebbcad35b3faac4aa30b
https://pubmed.ncbi.nlm.nih.gov/8590594
https://pubmed.ncbi.nlm.nih.gov/8590594
Autor:
Richard A. Lindberg, Gary M. Fox, Robin Elliott, Ming Zhang, Vann P. Parker, Brian Varnum, Anne Colombero, James D. Skrine, Yosef Yarden, Geraldine Trail, William J. Boyle, Tony Hunter, Timothy D. Bartley, Robert J. Toso, Andrew A. Welcher, Paige Holst, Elsa Fernandez, Brenda Guthrie, Robert W. Hunt, Hsieng Sen Lu
Publikováno v:
Nature. 368(6471)
A protein ligand for the ECK receptor protein-tyrosine kinase has been isolated by using the extracellular domain (ECK-X) of the receptor as an affinity reagent. Initially, concentrated cell culture supernatants were screened for receptor binding act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfe6cd33671c6f7b62ab9e11910d06e
https://pubmed.ncbi.nlm.nih.gov/8139691
https://pubmed.ncbi.nlm.nih.gov/8139691
Autor:
Jean-Claude Louis, Duanzhi Wen, Gary M. Fox, Zheng Hu, Rod Cupples, Paige Holst, Sylvia Hu, Laarni Antonio, Mei Fang, Shuqian Jing, Rami Tamir, Yanbin Yu, Yi Luo, Bruce W. Altrock
Publikováno v:
Cell. (7):1113-1124
We report the expression cloning and characterization of GDNFR-alpha, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF). GDNFR-alpha binds GDNF specifically and mediates activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf12d4895395020aece90c5bc49cd2c