Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Paige E. Mahaney"'
Autor:
Zhidong Chen, Carl A. Busacca, Shengli Ma, Xingzhong Zeng, Peter Allen Nemoto, Paige E. Mahaney, Jason A. Mulder, Chris H. Senanayake, Jun Wang, Nitinchandra D. Patel, Zhibin Li, Todd Bosanac, Daniel R. Fandrick, Jean-Nicolas Desrosiers, Heewon Lee, Sonia Rodriguez, Jon C. Lorenz, Nathan K. Yee, Joe Gao, Nelu Grinberg, Hidenori Takahashi, Alessandra Bartolozzi, Jinhua J. Song, Keith R. Fandrick
Publikováno v:
Organic Process Research & Development. 21:1427-1434
A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef81a6daa5f5e0f3f7a2d3016570bad
https://doi.org/10.1021/acs.oprd.7b00202
https://doi.org/10.1021/acs.oprd.7b00202
Autor:
Wenjun Tang, Jonathan T. Reeves, Christian Harcken, Heewon Lee, Zhulin Tan, Diana C. Reeves, Jinhua J. Song, Paige E. Mahaney, Carl A. Busacca, Chris H. Senanayake, Hossein Razavi, Zhengxu S. Han, Yibo Xu, Bing-Shiou Yang, Daniel Kuzmich
Publikováno v:
Organic Process Research & Development. 18:904-911
A highly enantioselective enamide hydrogenation route to the title amine was developed. Highlights of the synthesis include an efficient two-step synthesis of a 2-sulfonyl 4-pyridyl ethyl ketone, a simple enamide synthesis by direct condensation of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7c15d8bdc6de52c9a9d3c30e6c72243
https://doi.org/10.1021/op5001513
https://doi.org/10.1021/op5001513
Autor:
Ren Jianxin, Gontcharov Alexander, John R. Potoski, Zhixian Ding, Asaf Alimardanov, Paige E. Mahaney, Casey Cameron Mccomas, Antonia Nikitenko, Joseph Ashcroft, Mousumi Ghosh, Panolil Raveendranath, Levent Mahmut, Chan Anita Wai-Yin, Maotang Zhou
Publikováno v:
Organic Process Research & Development. 13:880-887
Development of a scalable synthesis of WAY-315193 is described. Use of LiHMDS as a base and Ti(O-i-Pr)4 as a Lewis acid was optimal for efficient and reproducible addition of indolinone anion to epoxyalcohol. Conversion of indolinone diol to indolino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::999ca2acb0b5d4027551d44f8585a793
https://doi.org/10.1021/op900141r
https://doi.org/10.1021/op900141r
Autor:
Lisa Borges-Marcucci, Christine Huard, KehDih Lai, George P. Vlasuk, Douglas C. Harnish, Stephen J. Gardell, Mark J. Evans, Paige E. Mahaney, Julie A. Krueger, Shuguang Wang, Robert V. Martinez
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G543-G552
The nuclear hormone receptor farnesoid X receptor (FXR) plays a critical role in the regulation of bile acid, triglyceride (TG), and cholesterol homeostasis. WAY-362450 (FXR-450/XL335) is a potent synthetic FXR agonist as characterized in luciferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4b88e8a098fdd5710036af27194aeb
https://doi.org/10.1152/ajpgi.90585.2008
https://doi.org/10.1152/ajpgi.90585.2008
Autor:
Casey Cameron Mccomas, Paige E. Mahaney, Darlene C. Deecher, Grace H. Johnston, Terefenko Eugene Anthony, Eugene John Trybulski, Elizabeth Koury, Puwen Zhang, An Vu, Jenifer A. Bray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6067-6070
A series of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors was discovered. Several compounds such as 15 and 20 showed good hNET potency. Compounds 15 and 20 also displayed ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10d315d14d5a7dfa8fd5b0e8d81e04c
https://doi.org/10.1016/j.bmcl.2008.10.026
https://doi.org/10.1016/j.bmcl.2008.10.026
Autor:
Zhidong Chen, Shengli Ma, Rolf Schmid, Frederic G. Buono, Keith R. Fandrick, Heewon Lee, Xingzhong Zeng, Sonia Rodriguez, Jean-Nicolas Desrosiers, Zhibin Li, Todd Bosanac, Nathan K. Yee, Paige E. Mahaney, Hidenori Takahashi, Chris H. Senanayake, Joe Gao, Daniel R. Fandrick, Peter Allen Nemoto, Bo Qu, Juergen Daeubler, Adil Duran, Elizabeth Archer, Alessandra Bartolozzi, Jinhua J. Song, Jason A. Mulder, Nitinchandra D. Patel, Nelu Grinberg, Carl A. Busacca, Michael Konrad
Publikováno v:
The Journal of organic chemistry. 80(3)
A practical sequence involving a noncryogenic stereospecific boronate rearrangement followed by a robust formylation with an in situ generated DCM anion has been developed for the asymmetric construction of an all-carbon quaternary stereogenic center
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0a84684926a76865b2c2fecd7837cb
https://pubmed.ncbi.nlm.nih.gov/25562342
https://pubmed.ncbi.nlm.nih.gov/25562342
Autor:
Paige E. Mahaney, Puwen Zhang, Casey C. McComas, Eugene John Trybulski, Ani Sarkahian, Nicole R. Sullivan, Liza Leventhal, Albert J. Uveges, Lisa Nogle, William L. Watts, An T. Vu
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8455-8466
Compounds with a combination of norepinephrine and serotonin reuptake inhibition have been approved in the US and Europe for a number of indications, including major depressive disorder and pain disorders such as diabetic neuropathy and fibromyalgia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf20c6072374d9fa11c4b618abfe2fa
https://doi.org/10.1016/j.bmc.2006.08.039
https://doi.org/10.1016/j.bmc.2006.08.039
Autor:
Paige E. Mahaney, Matthew L. Crawley, Igor Goljer, Douglas John Jenkins, Lisa Nogle, Rebecca Dooley, John F. Mehlmann
Publikováno v:
Organic Letters. 8:5837-5840
The first efficient and regioselective palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylates to give moderate to excellent yields of highly functionalized pyrroles has been developed. This approach is applicable to a range o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95837088bd06d664add5448c4ecc42c
https://doi.org/10.1021/ol062424p
https://doi.org/10.1021/ol062424p
Autor:
Robert John Steffan, Eugene John Trybulski, Douglas C. Harnish, Fei Ye, Paige E. Mahaney, Joseph P. Sabatucci, Michael Byron Webb, Christopher C. Chadwick
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:3455-3466
The anti-inflammatory activity of non-selective estrogens has been attributed to their ability to antagonize the activity of nuclear factor kappaB (NF-kappaB), a known mediator of inflammatory responses. Here we report the identification of a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20476238f8753f165de44d1230e89e5b
https://doi.org/10.1016/j.bmc.2006.01.001
https://doi.org/10.1016/j.bmc.2006.01.001
Autor:
Fei Ye, Lisa Nogle, Andrew Fensome, Darlene C. Deecher, Michael Anthony Marella, Jenifer A. Bray, Stephen Todd Cohn, Peter D. Alfinito, Puwen Zhang, Eugene John Trybulski, Grace H. Johnston, Casey Cameron Mccomas, An T. Vu, Paige E. Mahaney, Elizabeth Koury
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4929-4931
Norepinephrine and serotonin play an important role in a wide variety of biological processes and are implicated in a number of neurological disorders. A novel class of 1-(3-amino-1-phenylpropyl)indolin-2-ones was designed and synthesized that displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bfeaeb02372c7c9aeaff273c9424ec
https://doi.org/10.1016/j.bmcl.2008.08.060
https://doi.org/10.1016/j.bmcl.2008.08.060