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Autor:
Paige Dausinas Ni, Melissa Hartman, Jacob Slack, Christopher Basile, Sheng Liu, Jun Wan, Heather A. O'Leary
Publikováno v:
Journal of Cellular Physiology.
Publikováno v:
Proceedings of IMPRS. 3
Background: Hematopoietic stem and progenitor cells (HSC/HSPCs) inhabit niches within bone marrow that have significantly lower oxygen tension (1-4% O2, LowO2) than ambient air (21% O2) and provide signals regulating HSC signaling/function/self-renew
Publikováno v:
Experimental Hematology. 100:S70
Publikováno v:
Blood. 136:29-30
Introduction: The bone marrow (BM) microenvironment consists of low oxygen niches (~1-4%, low O2) that provide critical signals for hematopoietic stem and progenitor cell (HSC/HSPC) maintenance, self-renewal, and differentiation. However, the majorit
Publikováno v:
Experimental Hematology. 88:S40
Although the bone marrow low oxygen niche (∼1-4% low O2) provides critical signals for hematopoietic stem and progenitor cell (HSC/HSPC) maintenance, self-renewal and differentiation, the majority of studies are performed in room air (∼21% O2), o
Autor:
Paige Dausinas, Sridhar Rao, Kirthi Pulakanti, Richard Dahl, Karen D. Cowden Dahl, Jennifer M. Cole
Publikováno v:
Gene
ARID3A and ARID3B are paralogs from the AT-Rich interactive Domain (ARID) family. ARID3A and ARID3B associate to regulate genes in B-cells and cancer. We were the first to demonstrate that ARID3B regulates stem cell genes and promotes the cancer stem
Autor:
Rachel A. Sattler, Karen D. Cowden Dahl, Alexander S. Bobbs, Paige Dausinas, Prakash D. Nallathamby, Lynn Roy, Jeffrey L. Kurkewich
Publikováno v:
Cancer Growth and Metastasis, Vol 11 (2018)
Cancer Growth and Metastasis
Cancer Growth and Metastasis
Cancer stem cells (CSCs) are an attractive therapeutic target due to their predicted role in both metastasis and chemoresistance. One of the most commonly agreed on markers for ovarian CSCs is the cell surface protein CD133. CD133+ ovarian CSCs have
Publikováno v:
The Journal of biological chemistry. 292(42)
In ∼50% of prostate cancers, chromosomal rearrangements cause the fusion of the promoter and 5′-UTR of the androgen-regulated TMPRSS2 (transmembrane protease, serine 2) gene to the open reading frame of ERG, encoding an ETS family transcription f
Autor:
May Elbanna, Justin Budka, Paige Dausinas, Remi Adelaiye-Ogala, Nur Damayanti, Ashley Orillion, Eri Banno, Luigi Fontana, Roberto Pili
Publikováno v:
Cancer Research. 79:1611-1611
Background: Data from epidemiological studies have linked dietary intake to the development of prostate cancer (CaP). We have previously shown that dietary protein restriction inhibits tumor growth by modulating PI3K/mTOR signaling in vivo. Additiona