Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Pai-Sheng Chen"'
Publikováno v:
Translational Oncology, Vol 48, Iss , Pp 102062- (2024)
Breast cancer remains the most prevalent cancer in women globally, posing significant challenges in treatment due to the inevitable development of resistance to targeted therapies like everolimus, an mTOR inhibitor. While several mechanisms of resist
Externí odkaz:
https://doaj.org/article/4eb22f7e88f24e53ab2317f986f3fa32
Autor:
Chien-Hsun Huang, Chih-Ting Huang, Hsu-Yun Tsai, Yi-Chu Liao, Chiao-Mei Lin, Pei-Chen Chen, Jong-Shian Liou, Chin-Lin Hsu, Shih-Hau Chiu, Chien-Chi Chen, Sung-Yuan Hsieh, Hsin-Bai Zou, Cheng-Chih Hsu, Pai-Sheng Chen, Cheng-Yuan Kao, Jhen-Wei Ruan
Publikováno v:
Journal of Functional Foods, Vol 115, Iss , Pp 106110- (2024)
The emergence of next-generation probiotics (NGPs) has illuminated new possibilities for improving various diseases through food-grade supplements. In this study, a new gut bacterial species, designated as Akkermansia sp. BCRC 18949, was isolated fro
Externí odkaz:
https://doaj.org/article/3cdfef7df1024ee5bc06a784d08bf519
Autor:
Ching-Feng Chiu, Ji Min Park, Hsin-Hua Chen, Chen-Zou Mau, Pai-Sheng Chen, Yen-Hao Su, Hsin-An Chen, Yun-Ru Liu, Tsung-Han Hsieh, Chien-Chao Chiu, Shao-Wen Hung, Cheng-Yi Kuo, Young-Mao Chen, Chi-Fen Chang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113520- (2022)
Oxaliplatin, a third-generation platinum derivative, has become one of the main chemotherapeutic treatments for esophagus, gastric and colorectal cancer; however, it is still unclear the potential effectiveness for pancreatic ductal adenocarcinoma (P
Externí odkaz:
https://doaj.org/article/75a78c224ec1452c9ae4ac7e5785c4ae
Autor:
Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang, Shaw-Jenq Tsai
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-19 (2020)
Abstract Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions. All nucleated cells can sense oxygen co
Externí odkaz:
https://doaj.org/article/cd8e712c9f3a4b0ab49d354459cb21f8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
MicroRNAs (miRNAs) are small non-coding RNAs which post-transcriptionally suppress target mRNAs expression and/or translation to modulate pathophyological processes. Expression and function of miRNAs are fine-tuned by a conserved biogenesis machinery
Externí odkaz:
https://doaj.org/article/570dde2c23514294900e23939625e293
Autor:
Hui‐Huang Lai, Chih‐Wei Li, Chih‐Chen Hong, Hung‐Yu Sun, Ching‐Feng Chiu, Da‐Liang Ou, Pai‐Sheng Chen
Publikováno v:
Molecular Oncology, Vol 13, Iss 4, Pp 928-945 (2019)
Hepatocellular carcinoma (HCC) is a lethal human malignancy and a leading cause of cancer‐related death worldwide. Patients with HCC are often diagnosed at an advanced stage, and the prognosis is usually poor. The multikinase inhibitor sorafenib is
Externí odkaz:
https://doaj.org/article/930d5ccc72814ecf8d2a8f7129a23b8b
Autor:
Jer-Hwa Chang, Chao-Wen Cheng, Yi-Chieh Yang, Wan-Shen Chen, Wen-Yueh Hung, Jyh-Ming Chow, Pai-Sheng Chen, Michael Hsiao, Wei-Jiunn Lee, Ming-Hsien Chien
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-16 (2018)
Abstract Background Metastasis rather than the primary cancer determines the survival of cancer patients. Activation of Akt plays a critical role in the epithelial-to-mesenchymal transition (EMT), the initial step in lung cancer metastasis. Apigenin
Externí odkaz:
https://doaj.org/article/9b30ba857f0d4aaa94401846f26c4a42
Autor:
Jie-Ning Li, Pai-Sheng Chen, Ching-Feng Chiu, Yu-Jhen Lyu, Chiao Lo, Li-Wei Tsai, Ming-Yang Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 208 (2021)
TAR (HIV-1) RNA binding protein 2 (TARBP2) is an RNA-binding protein participating in cytoplasmic microRNA processing. Emerging evidence has shown the oncogenic role of TARBP2 in promoting cancer progression, making it an unfavorable prognosis marker
Externí odkaz:
https://doaj.org/article/475b7660c40a4d2385103d190af794ff
Autor:
Hui-Huang Lai, Pai-Sheng Chen
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 5 (2018)
Although downregulation of DICER – a critical enzyme in microRNA (miRNA) maturation – reportedly promotes cancer metastasis, understanding of its upstream regulators remains limited. Our recent study demonstrated a noncanonical oncogenic effect o
Externí odkaz:
https://doaj.org/article/ca2c69da7e0f4611a9cfc5863886ae7a
Autor:
Pai-Sheng Chen, 陳百昇
97
Connective tissue growth factor (CTGF) expression is elevated in advanced stages of breast cancer, but the regulatory role of CTGF in invasive breast cancer cell phenotypes is unclear. In the first part (Chapter 1), we found that over-express
Connective tissue growth factor (CTGF) expression is elevated in advanced stages of breast cancer, but the regulatory role of CTGF in invasive breast cancer cell phenotypes is unclear. In the first part (Chapter 1), we found that over-express
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/52729798919575180089