Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling.

Autor: Lee JY; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea., Park S; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea., Park EJ; Division of Colon and Rectal Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Pagire HS; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, South Korea., Pagire SH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, South Korea., Choi BW; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, South Korea., Park M; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea., Fang S; Department of Biomedical Sciences, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea., Ahn JH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, South Korea; JD Bioscience Inc., Gwangju, South Korea. Electronic address: jhahn@gist.ac.kr., Oh CM; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea. Electronic address: cmoh@gist.ac.kr.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Oct; Vol. 179, pp. 117428. Date of Electronic Publication: 2024 Sep 09.

Activation mechanism and novel binding sites of the BK Ca channel activator CTIBD.

Autor: Lee N; https://ror.org/024kbgz78 School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Kim S; https://ror.org/024kbgz78 School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Lee NY; https://ror.org/024kbgz78 School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Jo H; https://ror.org/024kbgz78 School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Jeong P; Department of Chemistry, Duke University, Durham, NC, USA., Pagire HS; https://ror.org/024kbgz78 Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Pagire SH; https://ror.org/024kbgz78 Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Ahn JH; https://ror.org/024kbgz78 Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Jin MS; https://ror.org/024kbgz78 School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea misunjin@gist.ac.kr., Park CS; https://ror.org/024kbgz78 School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea cspark@gist.ac.kr.

Publikováno v: Life science alliance [Life Sci Alliance] 2024 Aug 01; Vol. 7 (10). Date of Electronic Publication: 2024 Aug 01 (Print Publication: 2024).

Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.

Autor: Oh CJ; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea., Kim MJ; Department of Internal Medicine, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea., Lee JM; Cell & Matrix Research Institute, Kyungpook National University, Daegu, Republic of Korea., Kim DH; Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu, Republic of Korea., Kim IY; Department of Molecular Medicine, College of Medicine, Gachon University, Incheon, Republic of Korea; Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea., Park S; Department of Exercise Rehabilitation, Gachon University, Incheon, Republic of Korea., Kim Y; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Republic of Korea., Lee KB; Center for Research Equipment (104-Dong), Korea Basic Science Institute, Ochang, Cheongju, Chungbuk, Republic of Korea., Lee SH; Center for Research Equipment (104-Dong), Korea Basic Science Institute, Ochang, Cheongju, Chungbuk, Republic of Korea., Lim CW; Department of Medicine, Graduate School, Daegu Catholic University, Gyeongsan, Gyeongbuk, Republic of Korea., Kim M; Department of Medicine, Graduate School, Daegu Catholic University, Gyeongsan, Gyeongbuk, Republic of Korea., Lee JY; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea., Pagire HS; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea., Pagire SH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea., Bae MA; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea., Chanda D; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea., Thoudam T; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea., Khang AR; Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University College of Medicine, Yangsan, Republic of Korea., Harris RA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA., Ahn JH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. Electronic address: jhahn@gist.ac.kr., Jeon JH; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea. Electronic address: jeonjh@knu.ac.kr., Lee IK; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. Electronic address: leei@knu.ac.kr.

Publikováno v: Kidney international [Kidney Int] 2023 Oct; Vol. 104 (4), pp. 724-739. Date of Electronic Publication: 2023 Jul 01.

Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT 2A receptor antagonists for nonalcoholic fatty liver disease.

Autor: Kim M; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea., Choi W; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea; Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea., Yoon J; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea., Jeong BK; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea; Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea., Pagire SH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea., Pagire HS; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea., Park J; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea; Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea., Nam JE; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea; Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea., Oh CJ; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea., Jeon JH; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea; Department of Internal Medicine, Kyungpook National University Hospital and School of Medicine, Kyungpook National University, Daegu, 700-721, South Korea., Kim SS; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea., Lee BH; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea., Song JS; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea., Bae MA; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea., Lee IK; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea., Kim H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea; Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea. Electronic address: hailkim@kaist.ac.kr., Ahn JH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; JD Bioscience, 208 Cheomdan-dwagiro, Buk-gu, Gwangju, 61005, South Korea. Electronic address: jhahn@gist.ac.kr.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2022 Sep 05; Vol. 239, pp. 114517. Date of Electronic Publication: 2022 Jun 15.

Identification and Characterization of a Novel Large-Conductance Calcium-Activated Potassium Channel Activator, CTIBD, and Its Relaxation Effect on Urinary Bladder Smooth Muscle.

Autor: Lee N; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Lim BH; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Lee KS; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Shin J; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Pagire HS; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Pagire SH; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Ahn JH; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Lee SW; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Kang TM; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.)., Park CS; School of Life Sciences, Center for AI-applied High Efficiency Drug Discovery and Integrated Institute of Biomedical Research (N.L., C.-S.P.) and Department of Chemistry (H.S.P., S.H.P., J.H.A.), Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.H.L., K.-S.L., J.S., S.W.L.); and Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea (T.M.K.) cspark@gist.ac.kr.

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2021 Feb; Vol. 99 (2), pp. 114-124. Date of Electronic Publication: 2020 Dec 02.