Antitubercular Triazines: Optimization and Intrabacterial Metabolism.

Autor: Wang X; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Inoyama D; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Russo R; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Li SG; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Jadhav R; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Stratton TP; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Mittal N; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Bilotta JA; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Singleton E; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Kim T; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Paget SD; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Pottorf RS; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Ahn YM; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Davila-Pagan A; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Kandasamy S; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Grady C; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Hussain S; Genomics Center, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Soteropoulos P; Genomics Center, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Zimmerman MD; Public Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA., Ho HP; Public Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA., Park S; Public Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA., Dartois V; Public Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA., Ekins S; Collaborations in Chemistry Inc., Raleigh, NC 27606, USA., Connell N; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Kumar P; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA., Freundlich JS; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA. Electronic address: freundjs@rutgers.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2020 Feb 20; Vol. 27 (2), pp. 172-185.e11. Date of Electronic Publication: 2019 Nov 08.

Novel Pyrimidines as Antitubercular Agents.

Autor: Inoyama D; Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Paget SD; Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Russo R; Division of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Kandasamy S; Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Kumar P; Division of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Singleton E; Division of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Occi J; Division of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Tuckman M; Division of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Zimmerman MD; Public Health Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Ho HP; Public Health Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Perryman AL; Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Dartois V; Public Health Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Connell N; Division of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA., Freundlich JS; Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA freundjs@rutgers.edu.; Division of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Feb 23; Vol. 62 (3). Date of Electronic Publication: 2018 Feb 23 (Print Publication: 2018).

Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery.

Autor: Ekins S; Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA. ekinssean@yahoo.com, Reynolds RC, Kim H, Koo MS, Ekonomidis M, Talaue M, Paget SD, Woolhiser LK, Lenaerts AJ, Bunin BA, Connell N, Freundlich JS

Publikováno v: Chemistry & biology [Chem Biol] 2013 Mar 21; Vol. 20 (3), pp. 370-8.

Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.

Autor: Paget SD; Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA., Boggs CM, Foleno BD, Goldschmidt RM, Hlasta DJ, Weidner-Wells MA, Werblood HM, Bush K, Macielag MJ

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Sep 01; Vol. 16 (17), pp. 4537-42. Date of Electronic Publication: 2006 Jun 27.