O-GlcNAc transferase acts as a critical nutritional node for the control of liver homeostasis

Autor: Ortega-Prieto, Paula, Parlati, Lucia, Benhamed, Fadila, Regnier, Marion, Cavalcante, Isadora, Montabord, Mélanie, Onifarasoaniaina, Rachel, Favier, Maryline, Pavlovic, Natasa, Magusto, Julie, Cauzac, Michèle, Pagesy, Patrick, Gautheron, Jérémie, Desdouets, Chantal, Guilmeau, Sandra, Issad, Tarik, Postic, Catherine

Publikováno v: In JHEP Reports February 2024 6(2)

Short O-GlcNAcase Is Targeted to the Mitochondria and Regulates Mitochondrial Reactive Oxygen Species Level.

Autor: Pagesy, Patrick¹ (AUTHOR) patrick.pagesy@inserm.fr, Bouaboud, Abdelouhab¹ (AUTHOR) abdelouhab.bouaboud@inserm.fr, Feng, Zhihao¹ (AUTHOR) zhihao.feng@inserm.fr, Hulin, Philippe² (AUTHOR) philippe.hulin@univ-nantes.fr, Issad, Tarik¹ (AUTHOR) tarik.issad@inserm.fr

Publikováno v: Cells (2073-4409). Jun2022, Vol. 11 Issue 11, p1827-1827. 15p.

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Short OGA (O-GlcNAcase) is targeted to the mitochondria and regulates mitochondrial reactive oxygen species level

Autor: Pagesy, Patrick, Bouaboud, Abdelouhab, Feng, Zhihao, Hulin, Philippe, Issad, Tarik

O-GlcNAcylation is a reversible post-translational modification involved the regulation of cytosolic, nuclear and mitochondrial proteins. Only two enzymes, OGT and OGA, control attachment and removal of O-GlcNAc on proteins, respectively. Whereas a v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::73038c9b65ae97dab10902fa7ec2b160
https://hal.archives-ouvertes.fr/hal-03503480

O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells

Autor: Filhoulaud, Gaelle, Benhamed, Fadila, Pagesy, Patrick, Bonner, Caroline, Fardini, Yann, Ilias, Anissa, Movassat, Jamileh, Burnol, Anne-Francoise, Guilmeau, Sandra, Kerr-Conte, Julie, Pattou, François, Issad, Tarik, Postic, Catherine

Publikováno v: Frontiers in Endocrinology
Frontiers in Endocrinology, 2019, 10, ⟨10.3389/fendo.2019.00291⟩
Frontiers in Endocrinology, 2019, 10, pp.291. ⟨10.3389/fendo.2019.00291⟩
Frontiers in Endocrinology, Frontiers, 2019, 10, pp.291. ⟨10.3389/fendo.2019.00291⟩

International audience; Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a central mediator of glucotoxicity in pancreatic β cells. TxNIP is a scaffold protein interacting with target proteins to inhibit or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ee944b63591de172b5b90394fc8ccff7
https://hal.science/hal-03963707