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A scalable downstream process for the purification of the cell culture-derived Orf virus for human or veterinary applications

Autor: Lothert, K., Pagallies, F., Eilts, F., Sivanesapillai, A., Hardt, M., Moebus, A., Feger, T., Amann, R., Wolff, M.W.

The large demand for safe and efficient viral vector-based vaccines and gene therapies against both inherited and acquired diseases accelerates the development of viral vectors. One outstanding example, the Orf virus, has a wide range of applications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::38e20a67ad90beda085c4d1ed445dafc
https://publica.fraunhofer.de/handle/publica/265286

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A scalable downstream process for the purification of the cell culture-derived Orf virus for human or veterinary applications.

Autor: Lothert K; Institute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen (THM), Giessen, Germany., Pagallies F; Department of Immunology, University of Tuebingen, Tuebingen, Germany., Eilts F; Institute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen (THM), Giessen, Germany., Sivanesapillai A; Institute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen (THM), Giessen, Germany., Hardt M; Imaging Unit, Biomedical Research Centre Seltersberg, Justus Liebig University, Giessen, Germany., Moebus A; Imaging Unit, Biomedical Research Centre Seltersberg, Justus Liebig University, Giessen, Germany., Feger T; Department of Immunology, University of Tuebingen, Tuebingen, Germany., Amann R; Department of Immunology, University of Tuebingen, Tuebingen, Germany., Wolff MW; Institute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen (THM), Giessen, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Giessen, Germany. Electronic address: Michael.Wolff@lse.thm.de.

Publikováno v: Journal of biotechnology [J Biotechnol] 2020 Nov 10; Vol. 323, pp. 221-230. Date of Electronic Publication: 2020 Aug 27.