The Generation of ROS by Exposure to Trihalomethanes Promotes the IκBα/NF-κB/p65 Complex Dissociation in Human Lung Fibroblast.

Autor: Nájera-Martínez M; Laboratorio de Toxicología Ambiental, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, Mexico City 07738, Mexico., Lara-Vega I; Laboratorio de Toxicología Ambiental, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, Mexico City 07738, Mexico., Avilez-Alvarado J; Laboratorio de Visión Artificial, Unidad Culhuacán, Escuela Superior de Ingeniería Mecánica y Eléctrica, Instituto Politécnico Nacional, Av. Santa Ana 1000, San Francisco Culhuacán CTM V, Mexico City 04440, Mexico., Pagadala NS; LigronBio Inc., 10918 Technology Pl, San Diego, CA 92127, USA., Dzul-Caamal R; Instituto EPOMEX, Universidad Autónoma de Campeche, Av. Héroe de Nacozari No. 480, Campeche 24070, Mexico., Domínguez-López ML; Laboratorio de Inmunoquímica I, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala s/n, Casco de Santo Tomás, Mexico City 11340, Mexico., Tuszynski J; Li Ka Shing Applied Virology Institute, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Vega-López A; Laboratorio de Toxicología Ambiental, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, Mexico City 07738, Mexico.

Publikováno v: Biomedicines [Biomedicines] 2024 Oct 20; Vol. 12 (10). Date of Electronic Publication: 2024 Oct 20.

Discovery of anti-influenza nucleoside triphosphates targeting the catalytic site of A/PR/8/34/H1N1 polymerase.

Autor: Pagadala NS; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1 Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB Canada., Bhat R; Precision Bio Laboratories, Edmonton, AB Canada., Kumar D J; Department of Biotechnology, Sir M. Visvesvaraya Institute of Technology, Bangalore, India., Landi A; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1 Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB Canada.

Publikováno v: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2020; Vol. 29 (8), pp. 1463-1477. Date of Electronic Publication: 2020 May 24.

AZT acts as an anti-influenza nucleotide triphosphate targeting the catalytic site of A/PR/8/34/H1N1 RNA dependent RNA polymerase.

Autor: Pagadala NS; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada. nattu251@gmail.com.; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada. nattu251@gmail.com.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada. nattu251@gmail.com.; Medical Microbiology and Immunology, Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, T6G 2E1, Canada. nattu251@gmail.com.

Publikováno v: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2019 Apr; Vol. 33 (4), pp. 387-404. Date of Electronic Publication: 2019 Feb 09.

Software for molecular docking: a review.

Autor: Pagadala NS; Department of Medical Microbiology and Immunology, Li Ka Shing Institute of Virology, 6-020 Katz Group Centre, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada. nattu251@gmail.com., Syed K; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, 9300, Free State, South Africa., Tuszynski J; Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.; Department of Physics, University of Alberta, Edmonton, Alberta, Canada.

Publikováno v: Biophysical reviews [Biophys Rev] 2017 Apr; Vol. 9 (2), pp. 91-102. Date of Electronic Publication: 2017 Jan 16.

Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s.

Autor: Parvez M; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Qhanya LB; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Mthakathi NT; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Kgosiemang IK; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Bamal HD; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Pagadala NS; Department of Medical Microbiology and Immunology, 6-020 Katz Group Centre, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Xie T; College of Informatics, Huazhong Agricultural University, Wuhan, Hubei Province, China., Yang H; College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China., Chen H; College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China., Theron CW; Faculty of Natural and Agricultural Science, Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa., Monyaki R; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Raselemane SC; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Salewe V; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Mongale BL; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Matowane RG; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Abdalla SM; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Booi WI; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., van Wyk M; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Olivier D; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Boucher CE; Faculty of Natural and Agricultural Science, Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa., Nelson DR; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Tuszynski JA; Department of Physics, University of Alberta, Edmonton, Alberta T6G 2J1, Canada., Blackburn JM; Institute of Infectious Disease &Molecular Medicine; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa., Yu JH; Department of Bacteriology, University of Wisconsin-Madison, 3155 MSB, 1550 Linden Drive, Madison WI 53706, USA., Mashele SS; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa., Chen W; College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China., Syed K; Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa.

Publikováno v: Scientific reports [Sci Rep] 2016 Sep 12; Vol. 6, pp. 33099. Date of Electronic Publication: 2016 Sep 12.