VerSe: a vertebrae labelling and segmentation benchmark for multi-detector CT images

Autor: Sekuboyina, A, Husseini, ME, Bayat, A, Löffler, M, Liebl, H, Li, H, Tetteh, G, Kukačka, J, Payer, C, Štern, D, Urschler, M, Chen, M, Cheng, D, Lessmann, N, Hu, Y, Wang, T, Yang, D, Xu, D, Ambellan, F, Amiranashvili, T, Ehlke, M, Lamecker, H, Lehnert, S, Lirio, M, Olaguer, NPD, Ramm, H, Sahu, M, Tack, A, Zachow, S, Jiang, T, Ma, X, Angerman, C, Wang, X, Brown, K, Wolf, M, Kirszenberg, A, Puybareau, É, Chen, D, Bai, Y, Rapazzo, BH, Yeah, T, Zhang, A, Xu, S, Hou, F, He, Z, Zeng, C, Xiangshang, Z, Liming, X, Netherton, TJ, Mumme, RP, Court, LE, Huang, Z, He, C, Wang, L-W, Ling, SH, Huynh, LD, Boutry, N, Jakubicek, R, Chmelik, J, Mulay, S, Sivaprakasam, M, Paetzold, JC, Shit, S, Ezhov, I, Wiestler, B, Glocker, B, Valentinitsch, A, Rempfler, M, Menze, BH, Kirschke, JS

Vertebral labelling and segmentation are two fundamental tasks in an automated spine processing pipeline. Reliable and accurate processing of spine images is expected to benefit clinical decision-support systems for diagnosis, surgery planning, and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::0c553dbf00d834946329e340e6bbd1f3
http://hdl.handle.net/10044/1/87702

Virtual reality-empowered deep-learning analysis of brain cells.

Autor: Kaltenecker D; Institute for Diabetes and Cancer (IDC), Helmholtz Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany., Al-Maskari R; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany.; Department of Computer Science, TUM Computation, Information and Technology, Technical University of Munich (TUM), Munich, Germany.; Center for Translational Cancer Research of the TUM (TranslaTUM), Munich, Germany., Negwer M; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany., Hoeher L; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany., Kofler F; Department of Computer Science, TUM Computation, Information and Technology, Technical University of Munich (TUM), Munich, Germany.; Center for Translational Cancer Research of the TUM (TranslaTUM), Munich, Germany.; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Helmholtz AI, Helmholtz Munich, Neuherberg, Germany., Zhao S; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany., Todorov M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany., Rong Z; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany., Paetzold JC; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany.; Center for Translational Cancer Research of the TUM (TranslaTUM), Munich, Germany.; Department of Computing, Imperial College London, London, United Kingdom., Wiestler B; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Piraud M; Helmholtz AI, Helmholtz Munich, Neuherberg, Germany., Rueckert D; Department of Computing, Imperial College London, London, United Kingdom., Geppert J; Institute for Diabetes and Cancer (IDC), Helmholtz Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Morigny P; Institute for Diabetes and Cancer (IDC), Helmholtz Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Rohm M; Institute for Diabetes and Cancer (IDC), Helmholtz Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Menze BH; Department of Computer Science, TUM Computation, Information and Technology, Technical University of Munich (TUM), Munich, Germany.; Department for Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Herzig S; Institute for Diabetes and Cancer (IDC), Helmholtz Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Chair Molecular Metabolic Control, TU Munich, Munich, Germany., Berriel Diaz M; Institute for Diabetes and Cancer (IDC), Helmholtz Munich, Neuherberg, Germany. mauricio.berrieldiaz@helmholtz-munich.de.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany. mauricio.berrieldiaz@helmholtz-munich.de.; German Center for Diabetes Research (DZD), Neuherberg, Germany. mauricio.berrieldiaz@helmholtz-munich.de., Ertürk A; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany. ali.erturk@helmholtz-munich.de.; Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Munich, Neuherberg, Germany. ali.erturk@helmholtz-munich.de.; School of Medicine, Koç University, İstanbul, Turkey. ali.erturk@helmholtz-munich.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ali.erturk@helmholtz-munich.de.; Deep Piction, Munich, Germany. ali.erturk@helmholtz-munich.de.

Publikováno v: Nature methods [Nat Methods] 2024 Jul; Vol. 21 (7), pp. 1306-1315. Date of Electronic Publication: 2024 Apr 22.

Retinal vasculature of different diameters and plexuses exhibit distinct vulnerability in varying severity of diabetic retinopathy.

Autor: Fayed AE; Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Giza, Egypt. alaa.fayed@kasralainy.edu.eg.; Watany Eye Hospital, Cairo, Egypt. alaa.fayed@kasralainy.edu.eg.; Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. alaa.fayed@kasralainy.edu.eg., Menten MJ; Lab for AI in Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; BioMedIA, Imperial College London, London, UK., Kreitner L; Lab for AI in Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Paetzold JC; Lab for AI in Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; BioMedIA, Imperial College London, London, UK., Rueckert D; Lab for AI in Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; BioMedIA, Imperial College London, London, UK., Bassily SM; Watany Eye Hospital, Cairo, Egypt., Fikry RR; Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Giza, Egypt.; Watany Eye Hospital, Cairo, Egypt., Hagag AM; NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Boehringer Ingelheim Limited, London, UK., Sivaprasad S; NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; University College London, London, UK.

Publikováno v: Eye (London, England) [Eye (Lond)] 2024 Jun; Vol. 38 (9), pp. 1762-1769. Date of Electronic Publication: 2024 Mar 21.

Benchmarking the CoW with the TopCoW Challenge: Topology-Aware Anatomical Segmentation of the Circle of Willis for CTA and MRA.

Autor: Yang K; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Musio F; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Center for Computational Health, Zurich University of Applied Sciences, Zurich, Switzerland., Ma Y; Department of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland.; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China., Juchler N; Center for Computational Health, Zurich University of Applied Sciences, Zurich, Switzerland., Paetzold JC; Department of Computing, Imperial College London, London, UK.; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Munich, Germany., Al-Maskari R; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Munich, Germany., Höher L; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Munich, Germany., Li HB; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, USA., Hamamci IE; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Sekuboyina A; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Shit S; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; School of Medicine, Technical University of Munich, Munich, Germany., Huang H; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Prabhakar C; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., de la Rosa E; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Waldmannstetter D; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Department of Informatics, Technical University of Munich, Munich, Germany., Kofler F; School of Medicine, Technical University of Munich, Munich, Germany.; Department of Informatics, Technical University of Munich, Munich, Germany.; Helmholtz AI, Helmholtz Munich, Munich, Germany., Navarro F; School of Medicine, Technical University of Munich, Munich, Germany.; Department of Informatics, Technical University of Munich, Munich, Germany., Menten M; Department of Informatics, Technical University of Munich, Munich, Germany.; Department of Computing, Imperial College London, London, UK., Ezhov I; Department of Informatics, Technical University of Munich, Munich, Germany., Rueckert D; Department of Informatics, Technical University of Munich, Munich, Germany.; Department of Computing, Imperial College London, London, UK., Vos I; Image Sciences Institute, UMC Utrecht, Utrecht, the Netherlands., Ruigrok Y; Department of Neurology, UMC Utrecht, Utrecht, the Netherlands., Velthuis B; Department of Radiology, UMC Utrecht, Utrecht, the Netherlands., Kuijf H; Image Sciences Institute, UMC Utrecht, Utrecht, the Netherlands., Hämmerli J; Department of Clinical Neurosciences, Division of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland., Wurster C; Department of Clinical Neurosciences, Division of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland., Bijlenga P; Department of Clinical Neurosciences, Division of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland., Westphal L; Department of Neurology, University Hospital of Zurich, Zurich, Switzerland., Bisschop J; Department of Physiology, University of Toronto, Toronto, Canada., Colombo E; Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland., Baazaoui H; Department of Neurology, University Hospital of Zurich, Zurich, Switzerland., Makmur A; Department of Diagnostic Imaging, National University Hospital, Singapore., Hallinan J; Department of Diagnostic Imaging, National University Hospital, Singapore., Wiestler B; School of Medicine, Technical University of Munich, Munich, Germany., Kirschke JS; School of Medicine, Technical University of Munich, Munich, Germany., Wiest R; Department of Diagnostic and Interventional Neuroradiology, University Hospital Berne and University of Berne, Berne, Switzerland., Montagnon E; Centre de Recherche du Centre Hospitalier de l'Université de Montreal (CRCHUM), Montreal, Canada., Letourneau-Guillon L; Centre de Recherche du Centre Hospitalier de l'Université de Montreal (CRCHUM), Montreal, Canada., Galdran A; Universitat Pompeu Fabra, Barcelona, Spain., Galati F; EURECOM, Biot, France., Falcetta D; EURECOM, Biot, France., Zuluaga MA; EURECOM, Biot, France., Lin C; Institute of Medical Technology, Peking University Health Science Center, Beijing, China., Zhao H; Institute of Medical Technology, Peking University Health Science Center, Beijing, China., Zhang Z; Hangzhou Genlight Medtech Co. Ltd., Hangzhou, China., Ra S; Department of Artificial Intelligence, Sungkyunkwan University, Seoul, Korea., Hwang J; Department of Artificial Intelligence, Sungkyunkwan University, Seoul, Korea., Park H; Department of Electrical and Computer Engineering, Sungkyunkwan University, Seoul, Korea., Chen J; Shanghai MediWorks Precision Instruments Co.,Ltd, Shanghai, China., Wodzinski M; Institute of Informatics, HES-SO Valais-Wallis, Switzerland.; Department of Measurement and Electronics, AGH University of Krakow, Poland., Müller H; Institute of Informatics, HES-SO Valais-Wallis, Switzerland., Shi P; Electronic & Information Engineering School, Harbin Institute of Technology (Shenzhen), Shenzhen, China., Liu W; Electronic & Information Engineering School, Harbin Institute of Technology (Shenzhen), Shenzhen, China., Ma T; Electronic & Information Engineering School, Harbin Institute of Technology (Shenzhen), Shenzhen, China.; Peng Cheng Laboratory, Shenzhen, China., Yalçin C; Research Institute of Computer Vision and Robotics (ViCOROB), Universitat de Girona, Catalonia, Spain., Hamadache RE; Research Institute of Computer Vision and Robotics (ViCOROB), Universitat de Girona, Catalonia, Spain., Salvi J; Research Institute of Computer Vision and Robotics (ViCOROB), Universitat de Girona, Catalonia, Spain., Llado X; Research Institute of Computer Vision and Robotics (ViCOROB), Universitat de Girona, Catalonia, Spain., Lal-Trehan Estrada UM; Research Institute of Computer Vision and Robotics (ViCOROB), Universitat de Girona, Catalonia, Spain., Abramova V; Research Institute of Computer Vision and Robotics (ViCOROB), Universitat de Girona, Catalonia, Spain., Giancardo L; Center for Precision Health, McWilliams School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, USA., Oliver A; Research Institute of Computer Vision and Robotics (ViCOROB), Universitat de Girona, Catalonia, Spain., Liu J; Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, China.; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China., Huang H; Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, China.; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China., Cui Y; Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, China.; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China., Lin Z; School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China., Liu Y; Department of Automation, Shanghai Jiao Tong University, Shanghai, China., Zhu S; School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China., Patel TR; Canon Stroke and Vascular Research Center, Buffalo, USA.; Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, USA.; Department of Neurosurgery, University at Buffalo, Buffalo, USA., Tutino VM; Canon Stroke and Vascular Research Center, Buffalo, USA.; Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, USA.; Department of Neurosurgery, University at Buffalo, Buffalo, USA.; Department of Biomedical Engineering, University at Buffalo, Buffalo, USA., Orouskhani M; Department of Radiology, University of Washington, Seattle, USA., Wang H; Department of Radiology, University of Washington, Seattle, USA., Mossa-Basha M; Department of Radiology, University of Washington, Seattle, USA., Zhu C; Department of Radiology, University of Washington, Seattle, USA., Rokuss MR; German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Germany.; Faculty of Mathematics and Computer Science, Heidelberg University, Germany., Kirchhoff Y; German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Germany.; Faculty of Mathematics and Computer Science, Heidelberg University, Germany.; HIDSS4Health - Helmholtz Information and Data Science School for Health, Karlsruhe/Heidelberg, Germany., Disch N; German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Germany.; Faculty of Mathematics and Computer Science, Heidelberg University, Germany.; HIDSS4Health - Helmholtz Information and Data Science School for Health, Karlsruhe/Heidelberg, Germany., Holzschuh J; German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Germany., Isensee F; German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Germany.; Helmholtz Imaging, German Cancer Research Center, Heidelberg, Germany., Maier-Hein K; German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Germany.; Pattern Analysis and Learning Group, Department of Radiation Oncology, Heidelberg University Hospital., Sato Y; LPIXEL Inc., Tokyo, Japan., Hirsch S; Center for Computational Health, Zurich University of Applied Sciences, Zurich, Switzerland., Wegener S; Department of Neurology, University Hospital of Zurich, Zurich, Switzerland., Menze B; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.

Publikováno v: ArXiv [ArXiv] 2024 Apr 29. Date of Electronic Publication: 2024 Apr 29.

Distinct molecular profiles of skull bone marrow in health and neurological disorders.

Autor: Kolabas ZI; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Munich, Germany., Kuemmerle LB; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Perneczky R; Division of Mental Health in Older Adults and Alzheimer Therapy and Research Center, Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University Munich, 80336 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK., Förstera B; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Ulukaya S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Ali M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Munich, Germany; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Kapoor S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Bartos LM; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Büttner M; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Caliskan OS; Institute for Diabetes and Obesity, Helmholtz Center Munich and German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Rong Z; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Munich Medical Research School (MMRS), 80336 Munich, Germany., Mai H; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Munich Medical Research School (MMRS), 80336 Munich, Germany., Höher L; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Jeridi D; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Molbay M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Khalin I; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Deligiannis IK; Helmholtz Pioneer Campus (HPC), Helmholtz Munich, Neuherberg, Germany., Negwer M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Roberts K; Wellcome Sanger Institute, Cambridge, UK., Simats A; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Carofiglio O; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Todorov MI; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Horvath I; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; School of Computation, Information and Technology (CIT), TUM, Boltzmannstr. 3, 85748 Garching, Germany., Ozturk F; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Hummel S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Biechele G; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Zatcepin A; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Unterrainer M; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Gnörich J; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Roodselaar J; Charité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Berlin, Germany., Shrouder J; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Khosravani P; Biomedical Center (BMC), Core Facility Flow Cytometry, Faculty of Medicine, LMU Munich, Munich, Germany., Tast B; Biomedical Center (BMC), Core Facility Flow Cytometry, Faculty of Medicine, LMU Munich, Munich, Germany., Richter L; Biomedical Center (BMC), Core Facility Flow Cytometry, Faculty of Medicine, LMU Munich, Munich, Germany., Díaz-Marugán L; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Kaltenecker D; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Diabetes and Cancer, Helmholtz Munich, Munich, Germany., Lux L; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Chen Y; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Zhao S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Rauchmann BS; Division of Mental Health in Older Adults and Alzheimer Therapy and Research Center, Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University Munich, 80336 Munich, Germany; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; Institute of Neuroradiology, University Hospital LMU, Munich, Germany., Sterr M; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany., Kunze I; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany., Stanic K; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Kan VWY; Institute of Clinical Neuroimmunology, University Hospital Munich, Ludwig-Maximilians University Munich, Munich, Germany., Besson-Girard S; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Munich, Germany., Katzdobler S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Palleis C; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Schädler J; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Paetzold JC; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Department of Computing, Imperial College London, London, UK., Liebscher S; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute of Clinical Neuroimmunology, University Hospital Munich, Ludwig-Maximilians University Munich, Munich, Germany; Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians Universität Munich, Munich, Germany., Hauser AE; Charité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Berlin, Germany., Gokce O; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Lickert H; Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; TUM School of Medicine, Technical University of Munich, Munich, Germany., Steinke H; Institute of Anatomy, University of Leipzig, 04109 Leipzig, Germany., Benakis C; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Braun C; Institute of Legal Medicine, Faculty of Medicine, LMU Munich, Germany., Martinez-Jimenez CP; Helmholtz Pioneer Campus (HPC), Helmholtz Munich, Neuherberg, Germany; TUM School of Medicine, Technical University of Munich, Munich, Germany., Buerger K; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Albert NL; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Höglinger G; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Haass C; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Kopczak A; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Dichgans M; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Havla J; Institute of Clinical Neuroimmunology, University Hospital Munich, Ludwig-Maximilians University Munich, Munich, Germany; Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians Universität Munich, Munich, Germany., Kümpfel T; Institute of Clinical Neuroimmunology, University Hospital Munich, Ludwig-Maximilians University Munich, Munich, Germany; Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians Universität Munich, Munich, Germany., Kerschensteiner M; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute of Clinical Neuroimmunology, University Hospital Munich, Ludwig-Maximilians University Munich, Munich, Germany; Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians Universität Munich, Munich, Germany., Schifferer M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Simons M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Liesz A; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Krahmer N; Institute for Diabetes and Obesity, Helmholtz Center Munich and German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Bayraktar OA; Wellcome Sanger Institute, Cambridge, UK., Franzmeier N; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Plesnila N; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Erener S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Delbridge C; Institute of Pathology, Department of Neuropathology, Technical University Munich, TUM School of Medicine, Munich, Germany., Bhatia HS; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Hellal F; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Elsner M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany., Bechmann I; Institute of Anatomy, University of Leipzig, 04109 Leipzig, Germany., Ondruschka B; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Brendel M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Theis FJ; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Mathematics, Technische Universität München, Garching bei München, Germany., Erturk A; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address: ali.erturk@helmholtz-munich.de.

Publikováno v: Cell [Cell] 2023 Aug 17; Vol. 186 (17), pp. 3706-3725.e29. Date of Electronic Publication: 2023 Aug 09.