Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Padmini S Kedar"'
Autor:
Aya Masaoka, Natalie R Gassman, Julie K Horton, Padmini S Kedar, Kristine L Witt, Cheryl A Hobbs, Grace E Kissling, Keizo Tano, Kenjiro Asagoshi, Samuel H Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66801 (2013)
The breast cancer 1 (BRCA1) protein is a tumor suppressor playing roles in DNA repair and cell cycle regulation. Studies of DNA repair functions of BRCA1 have focused on double-strand break (DSB) repair pathways and have recently included base excisi
Externí odkaz:
https://doaj.org/article/8c8ec1591f79421093a6465237cd408a
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49301 (2012)
Regulation of poly(ADP-ribose) (PAR) synthesis and turnover is critical to determining cell fate after genotoxic stress. Hyperactivation of PAR synthesis by poly(ADP-ribose) polymerase-1 (PARP-1) occurs when cells deficient in DNA repair are exposed
Externí odkaz:
https://doaj.org/article/5097241639b2458cb11e13c5211c71e8
Autor:
Elena K Braithwaite, Padmini S Kedar, Deborah J Stumpo, Barbara Bertocci, Jonathan H Freedman, Leona D Samson, Samuel H Wilson
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12229 (2010)
Base excision repair (BER) is a DNA repair pathway designed to correct small base lesions in genomic DNA. While DNA polymerase beta (pol beta) is known to be the main polymerase in the BER pathway, various studies have implicated other DNA polymerase
Externí odkaz:
https://doaj.org/article/39f1c48a89724a2ba4c79f86b70e38f8
Autor:
Samuel H. Wilson, Padmini S. Kedar, Natalie R. Gassman, Rajendra Prasad, Donna F. Stefanick, Julie K. Horton
PDF file - 422KB, S1. Cell survival as measured by a clonogenic assay. S2. BRCT I domain of XRCC1. S3. Characterization of cell lines by western blotting. S4. Characterization of full-length wild-type XRCC1 and L360R mutant XRCC1 mouse proteins. S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7400420d7d6dfc6266f20035e720ae73
https://doi.org/10.1158/1541-7786.22513761
https://doi.org/10.1158/1541-7786.22513761
Autor:
Julie K. Horton, Donna F. Stefanick, Natalie R. Gassman, Padmini S. Kedar, Samuel H. Wilson, Rajendra Prasad
Publikováno v:
Molecular Cancer Research. 12:1128-1139
PARP-1 is important for the recognition of both endogenous and exogenous DNA damage, and binds to DNA strand breaks including intermediates of base excision repair (BER). Once DNA-bound, PARP-1 becomes catalytically activated synthesizing PAR polymer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d3af8ce42bf5ad7d2d0ee812aa5e8e
https://doi.org/10.1158/1541-7786.mcr-13-0502
https://doi.org/10.1158/1541-7786.mcr-13-0502
Autor:
Robert E. London, Padmini S. Kedar, Donna F. Stefanick, Scott A. Gabel, Jason Williams, Rajendra Prasad, Eugene F. DeRose, Julie K. Horton, Samuel H. Wilson, Natalie R. Gassman, Matthew J. Cuneo, Esther W. Hou
Publikováno v:
DNA Repair. 12:774-785
Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key BER factors XRCC1 and DNA polymerase β (pol β) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51425136d698f44bfdfd141c9e68851e
https://doi.org/10.1016/j.dnarep.2013.06.004
https://doi.org/10.1016/j.dnarep.2013.06.004
Autor:
Samuel H. Wilson, Aya Masaoka, Natalie R. Gassman, Julie K. Horton, Padmini S. Kedar, Esther W. Hou, Michael Bustin, Rajendra Prasad
Publikováno v:
Journal of Biological Chemistry. 287:27648-27658
In mammalian cells, the nucleosome-binding protein HMGN1 (high mobility group N1) affects the structure and function of chromatin and plays a role in repair of damaged DNA. HMGN1 affects the interaction of DNA repair factors with chromatin and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6737275f2e3d551e41754b121343839
https://doi.org/10.1074/jbc.m112.370759
https://doi.org/10.1074/jbc.m112.370759
Autor:
Samuel H. Wilson, William A. Beard, Padmini S. Kedar, Rajendra Prasad, David D. Shock, Esther W. Hou, Yuan Liu
Publikováno v:
Journal of Biological Chemistry. 282:13532-13541
The individual steps in single-nucleotide base excision repair (SN-BER) are coordinated to enable efficient repair without accumulation of cytotoxic DNA intermediates. The DNA transactions and various proteins involved in SN-BER of abasic sites are w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e1504ac9eea7f453a9995e3df5dd64
https://doi.org/10.1074/jbc.m611295200
https://doi.org/10.1074/jbc.m611295200
Autor:
Tapas K. Hazra, Padmini S. Kedar, Sankar Mitra, Huxian Wang, Istvan Boldogh, Rajendra Prasad, Michael Weinfeld, Samuel H. Wilson, Lee R Wiederhold, Feridoun Karimi-Busheri, John B. Leppard, Alan E. Tomkinson, Aditi Das
Publikováno v:
DNA Repair. 5:1439-1448
DNA glycosylases/AP lyases initiate repair of oxidized bases in the genomes of all organisms by excising these lesions and then cleaving the DNA strand at the resulting abasic (AP) sites and generate 3' phospho alpha,beta-unsaturated aldehyde (3' PUA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89ab4177241578e54039ebef7279f34
https://doi.org/10.1016/j.dnarep.2006.07.003
https://doi.org/10.1016/j.dnarep.2006.07.003
Autor:
Samuel H. Wilson, Padmini S. Kedar, Anthony J. Robertson, Esther W. Hou, Soon-Jong Kim, Rajendra Prasad, Julie K. Horton
Publikováno v:
Journal of Biological Chemistry. 277:31115-31123
Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the DNA replication and DNA repair machinery. As such, PCNA interacts with many proteins that have a sequence motif termed the PCNA interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474ee1af80e3f34ccdb7030603081c1c
https://doi.org/10.1074/jbc.m201497200
https://doi.org/10.1074/jbc.m201497200