Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Padmini, Sarathchandra"'
Autor:
Magdi H. Yacoub, Yuan-Tsan Tseng, Jolanda Kluin, Annemijn Vis, Ulrich Stock, Hassiba Smail, Padmini Sarathchandra, Elena Aikawa, Hussam El-Nashar, Adrian H. Chester, Nairouz Shehata, Mohamed Nagy, Amr El-sawy, Wei Li, Gaetano Burriesci, Jacob Salmonsmith, Soha Romeih, Najma Latif
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence surv
Externí odkaz:
https://doaj.org/article/2f4de43f32a048168f38d511ee2a0394
Autor:
Sanooj Soni, Kieran P. O’Dea, Eiko Abe, Maryam Khamdan, Sneh V. Shah, Padmini Sarathchandra, Michael R. Wilson, Masao Takata
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Intra-alveolar microvesicles (MVs) are important mediators of inter-cellular communication within the alveolar space, and are key components in the pathophysiology of lung inflammation such as acute respiratory distress syndrome (ARDS). Despite the a
Externí odkaz:
https://doaj.org/article/265851e6466b47a68ddcac4cfd27882e
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveWe have previously reported that human calcified aortic cusps have abundant expression of smooth muscle (SM) markers and co-activators. We hypothesised that cells in bicuspid aortic valve (BAV) cusps and those affected by rheumatic heart val
Externí odkaz:
https://doaj.org/article/8cc065ee95e646978808c076c6b4ad6e
Autor:
Yuan-Tsan Tseng, Nabil F. Grace, Heba Aguib, Padmini Sarathchandra, Ann McCormack, Ahmed Ebeid, Nairouz Shehata, Mohamed Nagy, Hussam El-Nashar, Magdi H. Yacoub, Adrian Chester, Najma Latif
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
The success of tissue-engineered heart valves rely on a balance between polymer degradation, appropriate cell repopulation, and extracellular matrix (ECM) deposition, in order for the valves to continue their vital function. However, the process of r
Externí odkaz:
https://doaj.org/article/6a75da45e3e64689b220ba3ea0ce225e
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
A significant amount of knowledge has been gained with the use of cell-based assays to elucidate the mechanisms that mediate heart valve calcification. However, cells used in these studies lack their association with the extra-cellular matrix or the
Externí odkaz:
https://doaj.org/article/4457b22ff5b1487b8e807c789208d7cc
Autor:
Kuin Tian Pang, Mean Ghim, Chenghao Liu, Hui Min Tay, Chee Wai Fhu, Rui Ning Chia, Beiying Qiu, Padmini Sarathchandra, Adrian H. Chester, Magdi H. Yacoub, Fiona L. Wilkinson, Ria Weston, Christina M. Warboys, Han Wei Hou, Peter D. Weinberg, Xiaomeng Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular diseases. This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endot
Externí odkaz:
https://doaj.org/article/b145e3cb25094ce79750687149c1d057
Autor:
Joseph K. Yu, Padmini Sarathchandra, Adrian Chester, Magdi Yacoub, Thomas Brand, Jonathan T. Butcher
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Cardiac regeneration post-injury is a tantalizing feature of many lower vertebrates such as fishes and urodeles, but absent in adult humans. Restoration of pumping function is a key endpoint of cardiac regeneration, but very little is known
Externí odkaz:
https://doaj.org/article/887072574be04d6c86dd4928c7e5f23a
Autor:
Hessah Al-Shammari, Najma Latif, Padmini Sarathchandra, Ann McCormack, Eva A Rog-Zielinska, Shahzad Raja, Peter Kohl, Magdi H Yacoub, Rémi Peyronnet, Adrian H Chester
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240532 (2020)
BackgroundThe ability of heart valve cells to respond to their mechanical environment represents a key mechanism by which the integrity and function of valve cusps is maintained. A number of different mechanotransduction pathways have been implicated
Externí odkaz:
https://doaj.org/article/79c086a05be1422ea0e3e74733bd6ff0
Autor:
Magdi Yacoub, Yuan-Tsan Tseng, Jolanda Kluin, Annemijn Vis, Ulrich Stock, Hassiba Smail, Padmini Sarathchandra, Elena Aikawa, Hussam El-Nashar, Adrian Chester, Nairouz Shehata, Mohamed Nagy, Amr El-sawy, Gaetano Burriesci, Jacob Salmonsmith, Soha Romeih, Najma Latif
Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3e6f8b32dbcfa04d7c6f9f9261bd23a
https://doi.org/10.21203/rs.3.rs-2322351/v1
https://doi.org/10.21203/rs.3.rs-2322351/v1
Autor:
Kuin Tian Pang, Mean Ghim, Padmini Sarathchandra, Christina M. Warboys, Magdi H. Yacoub, Adrian H. Chester, Peter D. Weinberg
Publikováno v:
Biochemical and biophysical research communications. 642
Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional ("disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en