Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Padmavani Bezawada"'
Autor:
Adam D. Pierce, Padmavani Bezawada, David B. Neau, E. Prabhu Raman, David J. Weber, Paul T. Wilder, Kristen M. Varney, Eric A. Toth, Andrew Coop, Laura E. McKnight, Michael C. Cavalier, Alexander D. MacKerell, Milad J. Alasady, Mohd. Imran Ansari, Thomas H. Charpentier
Publikováno v:
Journal of Medicinal Chemistry. 59:592-608
The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B·p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. However, off-target effects associated with this drug were problematic in MM pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7129e63cfd8b8b77844ef5975d78bf5a
https://doi.org/10.1021/acs.jmedchem.5b01369
https://doi.org/10.1021/acs.jmedchem.5b01369
Autor:
Alexander D. MacKerell, Maureen A. Kane, Jihyun Shim, Andrew Coop, Rae R. Matsumoto, Jason R. Healy, Jace W. Jones, Padmavani Bezawada
Publikováno v:
ACS Chemical Neuroscience. 4:1256-1266
Opioid narcotics are used for the treatment of moderate-to-severe pain and primarily exert their analgesic effects through μ receptors. Although traditional μ agonists can cause undesired side effects, including tolerance, addition of δ antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5ec88caa47532b269a37f2f42f684f
https://doi.org/10.1021/cn4000428
https://doi.org/10.1021/cn4000428
Autor:
John R. Traynor, Christopher W. Cunningham, Andrea L. Devereaux, Nicholas W. Griggs, Andrew Coop, Rae R. Matsumoto, Jason R. Healy, Padmavani Bezawada
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(3)
Opioid analgesic tolerance remains a considerable drawback to chronic pain management. The finding that concomitant administration of delta opioid receptor (DOR) antagonists attenuates the development of tolerance to mu opioid receptor (MOR) agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2adfd9c1ad60c323965bd8bf373844
https://pubmed.ncbi.nlm.nih.gov/28011222
https://pubmed.ncbi.nlm.nih.gov/28011222
Autor:
Andrew Coop, Laura E. McKnight, Alexander D. MacKerell, Raquel Godoy-Ruiz, Padmavani Bezawada, Eric A. Toth, Kira G. Hartman, E.P. Raman, Paul T. Wilder, S Kudrimoti, David J. Weber
Publikováno v:
ACS Medicinal Chemistry Letters. 3:975-979
Molecular Dynamics simulations of the pentamidine-S100B complex, where two molecules of pentamidine bind per monomer of S100B, were performed in an effort to determine what properties would be desirable in a pentamidine-derived compound as an inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14d7459ce0ccf402761ec7df9e467cd
https://doi.org/10.1021/ml300166s
https://doi.org/10.1021/ml300166s
Publikováno v:
Tetrahedron Letters. 50:3772-3775
A stereoselective formal total synthesis of borrelidin is described. The synthetic strategy for synthesis of C1–C11 fragment features desymmetrization of Diels–Alder adduct, Sharpless asymmetric epoxidation, regioselective opening of chiral epoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba25b9789091f29ee606a8a0ada3323
https://doi.org/10.1016/j.tetlet.2009.03.196
https://doi.org/10.1016/j.tetlet.2009.03.196